DNAzyme-Powered DNA Walker for Cooperative Expression Imaging of Mutant p53 and Telomerase in Cancer Cells

Cooperative expression of multiple cancer biomarkers is of great significance in influencing cell pathways and drug treatment. However, the simultaneous analysis of low-abundance biomarkers in living cells remains a challenge. Here, we report a DNAzyme-powered DNA walker to visualize the cooperative...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-02, Vol.95 (8), p.4122-4130
Hauptverfasser:	Zhou, Ze-Rui, Li, Da-Wei, Qian, Ruo-Can, Ju, Huangxian
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analytical chemistry Biomarkers Cancer Cell activation Cells (biology) Chemistry Deoxyribonucleic acid DNA DNA - chemistry DNA, Catalytic - chemistry Fluorescence Gene expression Humans Mutants Neoplasms - diagnostic imaging Neoplasms - genetics Neoplasms - pathology p53 Protein Substrates Telomerase Telomerase - metabolism Tumor Suppressor Protein p53 - genetics
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