Proton-translocating NADH:ubiquinone oxidoreductase of Paracoccus denitrificans plasma membranes catalyzes FMN-independent reverse electron transfer to hexaammineruthenium (III)

NADH-OH, the specific inhibitor of NADH-binding site of the mammalian complex I, is shown to completely block FMN-dependent reactions of P. denitrificans enzyme in plasma membrane vesicles: NADH oxidation (in a competitive manner with Ki of 1 nM) as well as reduction of pyridine nucleotides, ferricy...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochimica et biophysica acta. Bioenergetics 2023-04, Vol.1864 (2), p.148963-148963, Article 148963
Hauptverfasser:	Gladyshev, Grigory V., Zharova, Tatyana V., Kareyeva, Alexandra V., Grivennikova, Vera G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Cell Membrane - metabolism Electron Transport Complex I - metabolism Electrons FMN Hexaammineruthenium (III) Mammals - metabolism NAD - metabolism NADH-OH NADH:ubiquinone oxidoreductase (complex I) Paracoccus denitrificans Protons Reverse electron transfer Ubiquinone - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!