Colon-targeted bacterial hydrogel for tumor vascular normalization and improved chemotherapy

The endogenous H2S plays an important role in the occurrence and development of colon cancer, and is related to the abnormal blood vessels. Here, we reported on a sulfhydryl hyaluronid-based hydrogel (HA-SH) synthesized by amide reaction and further obtained a bacterial hydrogel by loading Thiobacil...

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Veröffentlicht in:	Journal of controlled release 2023-04, Vol.356, p.59-71
Hauptverfasser:	Li, Wen, Fan, Jin-Xuan, Qiao, Ji-Yan, Chen, Qi-Wen, Sun, Yun-Xia, Zhang, Xian-Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Chemotherapy Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Humans Hydrogels - therapeutic use Hydrogen sulfide Living hydrogel Vascular normalization
Online-Zugang:	Volltext
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