Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2/HO-1 signaling pathway

•Macrophage polarization is a critical and initiating factor in atherosclerosis and related cardiovascular diseases in T2DM.•Astragalus polysaccharide potentiated anti-inflammatory responses by regulating macrophage subtype.•Activation of Nrf2/HO-1 by Astragalus polysaccharide alleviate macrophage a...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-04, Vol.112, p.154667-154667, Article 154667
Hauptverfasser:	Sha, Wenjun, Zhao, Bei, Wei, Huizhen, Yang, Yunyi, Yin, Hongping, Gao, Jie, Zhao, Weiwei, Kong, Wenwen, Ge, Guangbo, Lei, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Astragalus Plant Astragalus polysaccharide (APS) Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes vascular complications Endothelial Cells - metabolism Heme Oxygenase-1 - metabolism Inflammation - metabolism Lipopolysaccharides - pharmacology Macrophage polarization Macrophages - metabolism NF-E2-Related Factor 2 - metabolism Nrf2/HO-1 signaling pathway Polysaccharides - pharmacology Rats Reactive Oxygen Species - metabolism Signal Transduction Vascular endothelial dysfunction
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