In vitro complete differentiation of human spermatogonial stem cells to morphologic spermatozoa using a hybrid hydrogel of agarose and laminin

Spermatogenesis refers to the differentiation of the spermatogonial stem cells (SSCs) located in the base seminiferous tubules into haploid spermatozoa. Prerequisites for in vitro spermatogenesis include an extracellular matrix (ECM), paracrine factors, and testicular somatic cells which play a supp...

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Veröffentlicht in:	International journal of biological macromolecules 2023-04, Vol.235, p.123801-123801, Article 123801
Hauptverfasser:	Jabari, Ayob, Gholami, Keykavos, Khadivi, Farnaz, Koruji, Morteza, Amidi, Fardin, Gilani, Mohammad Ali Sadighi, Mahabadi, Vahid Pirhajati, Nikmahzar, Aghbibi, Salem, Maryam, Movassagh, Sepideh Ashouri, Feizollahi, Narjes, Abbasi, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agarose Cell Differentiation - physiology coculture electron microscopy extracellular matrix haploidy Humans Hybrid hydrogel hydrogels Hydrogels - pharmacology immunocytochemistry In vitro spermatogenesis Laminin Laminin - pharmacology Male meiosis quantitative polymerase chain reaction Sepharose Spermatogenesis spermatogonia Spermatogonial stem cells Spermatozoa spermiogenesis Stem Cells testes
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