Subgingival microbiome at different levels of cognition
Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts. Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sw...
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| creator | Fogelholm, Nele Leskelä, Jaakko Manzoor, Muhammed Holmer, Jacob Paju, Susanna Hiltunen, Kaija Roitto, Hanna-Maria Saarela, Riitta Kt Pitkälä, Kaisu Eriksdotter, Maria Buhlin, Kåre Pussinen, Pirkko J Mäntylä, Päivi |
| description | Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts.
Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions.
The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially Lachnospiraceae [XIV] at the family, genus, and species level increased with decreasing MMSE.
Cognitive decline is associated with obvious changes in the composition of the oral microbiota. Impaired cognition is accompanied with poor oral health status and the appearance of major taxa of the gut microbiota in the oral cavity. Good oral health-care practices require special deliberations among older adults. |
| doi_str_mv | 10.1080/20002297.2023.2178765 |
| format | Article |
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Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions.
The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially Lachnospiraceae [XIV] at the family, genus, and species level increased with decreasing MMSE.
Cognitive decline is associated with obvious changes in the composition of the oral microbiota. Impaired cognition is accompanied with poor oral health status and the appearance of major taxa of the gut microbiota in the oral cavity. Good oral health-care practices require special deliberations among older adults.</description><identifier>ISSN: 2000-2297</identifier><identifier>EISSN: 2000-2297</identifier><identifier>DOI: 10.1080/20002297.2023.2178765</identifier><identifier>PMID: 36844899</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Adults ; Cognition ; Cognition & reasoning ; Cognitive ability ; cognitive decline ; Composition ; Dental caries ; Gingiva ; Intestinal microflora ; Long-term care ; Microbiomes ; Microbiota ; Microorganisms ; mini mental state examination (MMSE) ; older adults ; Older people ; Oral cavity ; Oral health ; Oral hygiene ; Original ; Periodontitis ; rRNA 16S ; subgingival microbiome ; Taxa</subject><ispartof>JOURNAL OF ORAL MICROBIOLOGY, 2023, Vol.15 (1), p.2178765-2178765</ispartof><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2023</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2023 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c600t-8db7e6183642b04942e61d2d517097b4ad80b70727059d5013ad921503ccfba23</citedby><cites>FETCH-LOGICAL-c600t-8db7e6183642b04942e61d2d517097b4ad80b70727059d5013ad921503ccfba23</cites><orcidid>0000-0002-9627-2574 ; 0000-0002-2048-3420 ; 0000-0001-9659-6985 ; 0000-0003-3563-1876 ; 0000-0003-2091-972X ; 0000-0002-7939-1563 ; 0000-0002-1850-1757 ; 0000-0003-2498-4000 ; 0000-0002-3307-6605 ; 0000-0002-5466-2873 ; 0000-0001-9670-339X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946326/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946326/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,4010,27479,27900,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36844899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:152043716$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Fogelholm, Nele</creatorcontrib><creatorcontrib>Leskelä, Jaakko</creatorcontrib><creatorcontrib>Manzoor, Muhammed</creatorcontrib><creatorcontrib>Holmer, Jacob</creatorcontrib><creatorcontrib>Paju, Susanna</creatorcontrib><creatorcontrib>Hiltunen, Kaija</creatorcontrib><creatorcontrib>Roitto, Hanna-Maria</creatorcontrib><creatorcontrib>Saarela, Riitta Kt</creatorcontrib><creatorcontrib>Pitkälä, Kaisu</creatorcontrib><creatorcontrib>Eriksdotter, Maria</creatorcontrib><creatorcontrib>Buhlin, Kåre</creatorcontrib><creatorcontrib>Pussinen, Pirkko J</creatorcontrib><creatorcontrib>Mäntylä, Päivi</creatorcontrib><title>Subgingival microbiome at different levels of cognition</title><title>JOURNAL OF ORAL MICROBIOLOGY</title><addtitle>J Oral Microbiol</addtitle><description>Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts.
Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions.
The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially Lachnospiraceae [XIV] at the family, genus, and species level increased with decreasing MMSE.
Cognitive decline is associated with obvious changes in the composition of the oral microbiota. Impaired cognition is accompanied with poor oral health status and the appearance of major taxa of the gut microbiota in the oral cavity. Good oral health-care practices require special deliberations among older adults.</description><subject>Adults</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>cognitive decline</subject><subject>Composition</subject><subject>Dental caries</subject><subject>Gingiva</subject><subject>Intestinal microflora</subject><subject>Long-term care</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>mini mental state examination (MMSE)</subject><subject>older adults</subject><subject>Older people</subject><subject>Oral cavity</subject><subject>Oral health</subject><subject>Oral hygiene</subject><subject>Original</subject><subject>Periodontitis</subject><subject>rRNA 16S</subject><subject>subgingival 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(MMSE)</topic><topic>older adults</topic><topic>Older people</topic><topic>Oral cavity</topic><topic>Oral health</topic><topic>Oral hygiene</topic><topic>Original</topic><topic>Periodontitis</topic><topic>rRNA 16S</topic><topic>subgingival microbiome</topic><topic>Taxa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fogelholm, Nele</creatorcontrib><creatorcontrib>Leskelä, Jaakko</creatorcontrib><creatorcontrib>Manzoor, Muhammed</creatorcontrib><creatorcontrib>Holmer, Jacob</creatorcontrib><creatorcontrib>Paju, Susanna</creatorcontrib><creatorcontrib>Hiltunen, Kaija</creatorcontrib><creatorcontrib>Roitto, Hanna-Maria</creatorcontrib><creatorcontrib>Saarela, Riitta Kt</creatorcontrib><creatorcontrib>Pitkälä, Kaisu</creatorcontrib><creatorcontrib>Eriksdotter, Maria</creatorcontrib><creatorcontrib>Buhlin, Kåre</creatorcontrib><creatorcontrib>Pussinen, Pirkko J</creatorcontrib><creatorcontrib>Mäntylä, Päivi</creatorcontrib><collection>Taylor & 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Maria</au><au>Buhlin, Kåre</au><au>Pussinen, Pirkko J</au><au>Mäntylä, Päivi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subgingival microbiome at different levels of cognition</atitle><jtitle>JOURNAL OF ORAL MICROBIOLOGY</jtitle><addtitle>J Oral Microbiol</addtitle><date>2023</date><risdate>2023</risdate><volume>15</volume><issue>1</issue><spage>2178765</spage><epage>2178765</epage><pages>2178765-2178765</pages><issn>2000-2297</issn><eissn>2000-2297</eissn><abstract>Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts.
Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions.
The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially Lachnospiraceae [XIV] at the family, genus, and species level increased with decreasing MMSE.
Cognitive decline is associated with obvious changes in the composition of the oral microbiota. Impaired cognition is accompanied with poor oral health status and the appearance of major taxa of the gut microbiota in the oral cavity. Good oral health-care practices require special deliberations among older adults.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>36844899</pmid><doi>10.1080/20002297.2023.2178765</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9627-2574</orcidid><orcidid>https://orcid.org/0000-0002-2048-3420</orcidid><orcidid>https://orcid.org/0000-0001-9659-6985</orcidid><orcidid>https://orcid.org/0000-0003-3563-1876</orcidid><orcidid>https://orcid.org/0000-0003-2091-972X</orcidid><orcidid>https://orcid.org/0000-0002-7939-1563</orcidid><orcidid>https://orcid.org/0000-0002-1850-1757</orcidid><orcidid>https://orcid.org/0000-0003-2498-4000</orcidid><orcidid>https://orcid.org/0000-0002-3307-6605</orcidid><orcidid>https://orcid.org/0000-0002-5466-2873</orcidid><orcidid>https://orcid.org/0000-0001-9670-339X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Taylor & Francis Open Access Journals; Co-Action Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SWEPUB Freely available online |
| subjects | Adults Cognition Cognition & reasoning Cognitive ability cognitive decline Composition Dental caries Gingiva Intestinal microflora Long-term care Microbiomes Microbiota Microorganisms mini mental state examination (MMSE) older adults Older people Oral cavity Oral health Oral hygiene Original Periodontitis rRNA 16S subgingival microbiome Taxa |
| title | Subgingival microbiome at different levels of cognition |
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