Organocatalytic asymmetric synthesis of oxazolidino spiropyrazolinones via N , O -acetalization/aza Michael addition domino reaction between N -Boc pyrazolinone ketimines and γ-hydroxyenones

A squaramide-catalyzed asymmetric , -acetalization/aza Michael addition domino reaction between -Boc ketimines derived from pyrazolin-5-ones and γ-hydroxyenones has been developed for the construction of pyrazolinone embedded spirooxazolidines. A hydroquinine derived bifunctional squaramide catalyst...

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Veröffentlicht in:	Organic & biomolecular chemistry 2023-03, Vol.21 (11), p.2361-2369
Hauptverfasser:	Gil-Ordóñez, Marta, Martín, Laura, Maestro, Alicia, Andrés, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Asymmetry Cascade chemical reactions Catalysts Imines
Online-Zugang:	Volltext
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