Protecting the kidney in sepsis: resident macrophages to the rescue

Protecting the kidney in sepsis: resident macrophages to the rescue

Kidney resident macrophages exert pro-inflammatory or reparative effects in experimental acute kidney injury, but their role in sepsis is unclear. In a mouse model of sepsis, Privratsky et al. show that kidney resident F4/80hi macrophages protect against kidney injury by expressing interleukin-1 rec...

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Veröffentlicht in:Kidney international 2023-03, Vol.103 (3), p.461-463
Hauptverfasser: Burns, Kevin D., Douvris, Adrianna
Format: Artikel
Sprache:eng
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Acute Kidney Injury
Animals
Endothelial Cells
Kidney
Macrophages
Mice
Sepsis
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Douvris, Adrianna
description Kidney resident macrophages exert pro-inflammatory or reparative effects in experimental acute kidney injury, but their role in sepsis is unclear. In a mouse model of sepsis, Privratsky et al. show that kidney resident F4/80hi macrophages protect against kidney injury by expressing interleukin-1 receptor antagonist, which blocks interleukin-6 production selectively from endothelial cells. Discovery of this novel autocrine loop enhances opportunities for targeted therapies to diminish kidney injury during sepsis.
doi_str_mv 10.1016/j.kint.2022.11.012
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subjects Acute Kidney Injury
Animals
Endothelial Cells
Kidney
Macrophages
Mice
Sepsis
title Protecting the kidney in sepsis: resident macrophages to the rescue
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