Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease
Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, an...
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| Veröffentlicht in: | Parkinsonism & related disorders 2023-04, Vol.109, p.105312-105312, Article 105312 |
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| container_title | Parkinsonism & related disorders |
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| creator | Nagy, A.V. Leschziner, G. Eriksson, S.H. Lees, A. Noyce, A.J. Schrag, A. |
| description | Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear.
Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group.
Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p |
| doi_str_mv | 10.1016/j.parkreldis.2023.105312 |
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Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group.
Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p < 0.001). The prevalence of MCI level I was 12.8% in the lower-risk, 21.9% in the higher-risk (within the highest 15th percentile) and 64% in RBD participants; 66% of RBD participants had MCI level II with multi-domain MCI, but particularly attention and memory deficits.
Cognitive impairment is increased in different groups at higher risk of PD, particularly in the subgroup formally diagnosed with RBD.
•People with increased risk scores for Parkinson's disease show reduced cognitive function.•There is a particularly high rate of cognitive impairment in patients with REM-sleep behaviour disorder.•These are present especially in the domains of attention and memory.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2023.105312</identifier><identifier>PMID: 36827949</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cognition ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - psychology ; Epidemiology ; Humans ; Parkinson Disease - complications ; Parkinson Disease - diagnosis ; Parkinson Disease - epidemiology ; Parkinson's disease ; Prodrome ; REM Sleep Behavior Disorder - diagnosis ; REM Sleep Behavior Disorder - epidemiology ; REM Sleep Behavior Disorder - etiology ; REM-Sleep behaviour disorder ; Risk ; Sleep</subject><ispartof>Parkinsonism & related disorders, 2023-04, Vol.109, p.105312-105312, Article 105312</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-163a34e2f455e0930a3a8d1e341c38457aa5b4a49eb9facc0f67377e107c0e223</citedby><cites>FETCH-LOGICAL-c424t-163a34e2f455e0930a3a8d1e341c38457aa5b4a49eb9facc0f67377e107c0e223</cites><orcidid>0000-0002-9872-6680</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.parkreldis.2023.105312$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36827949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagy, A.V.</creatorcontrib><creatorcontrib>Leschziner, G.</creatorcontrib><creatorcontrib>Eriksson, S.H.</creatorcontrib><creatorcontrib>Lees, A.</creatorcontrib><creatorcontrib>Noyce, A.J.</creatorcontrib><creatorcontrib>Schrag, A.</creatorcontrib><title>Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear.
Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group.
Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p < 0.001). The prevalence of MCI level I was 12.8% in the lower-risk, 21.9% in the higher-risk (within the highest 15th percentile) and 64% in RBD participants; 66% of RBD participants had MCI level II with multi-domain MCI, but particularly attention and memory deficits.
Cognitive impairment is increased in different groups at higher risk of PD, particularly in the subgroup formally diagnosed with RBD.
•People with increased risk scores for Parkinson's disease show reduced cognitive function.•There is a particularly high rate of cognitive impairment in patients with REM-sleep behaviour disorder.•These are present especially in the domains of attention and memory.</description><subject>Cognition</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Prodrome</subject><subject>REM Sleep Behavior Disorder - diagnosis</subject><subject>REM Sleep Behavior Disorder - epidemiology</subject><subject>REM Sleep Behavior Disorder - etiology</subject><subject>REM-Sleep behaviour disorder</subject><subject>Risk</subject><subject>Sleep</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3DAURq2KigHKKyDvyiZT_yVOljAaWiRQq6pdWx77ptyZJA52MhJvX48G2iWra12dz599CKGcLTnj1ZftcrRxF6HzmJaCCZnXpeTiAznjtZZFyUV1ks-ylEXNBFuQ85S2jDFdMnlKFrKqhW5Uc0bcKvwZcMI9UOxHi7GHYaI40J_rxyJ1ACPdwJPdY5gjzW0heojUDj4zHvfoZ9slaicaMe1oaOmP_DAcUhg-pwMPNsEn8rHNFFy-zgvy-279a_WtePj-9X5181A4JdRU8EpaqUC0qiyBNZJZaWvPQSruZK1KbW25UVY1sGla6xxrKy21Bs60YyCEvCDXx3vHGJ5nSJPpMTnoOjtAmJMRus4Gqmwwo_URdTGkFKE1Y8TexhfDmTkoNlvzX7E5KDZHxTl69doyb3rw_4JvTjNwewQg_3WPEE1yCIMDjxHcZHzA91v-Aq9Dkq4</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Nagy, A.V.</creator><creator>Leschziner, G.</creator><creator>Eriksson, S.H.</creator><creator>Lees, A.</creator><creator>Noyce, A.J.</creator><creator>Schrag, A.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9872-6680</orcidid></search><sort><creationdate>202304</creationdate><title>Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease</title><author>Nagy, A.V. ; Leschziner, G. ; Eriksson, S.H. ; Lees, A. ; Noyce, A.J. ; Schrag, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-163a34e2f455e0930a3a8d1e341c38457aa5b4a49eb9facc0f67377e107c0e223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cognition</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Prodrome</topic><topic>REM Sleep Behavior Disorder - diagnosis</topic><topic>REM Sleep Behavior Disorder - epidemiology</topic><topic>REM Sleep Behavior Disorder - etiology</topic><topic>REM-Sleep behaviour disorder</topic><topic>Risk</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagy, A.V.</creatorcontrib><creatorcontrib>Leschziner, G.</creatorcontrib><creatorcontrib>Eriksson, S.H.</creatorcontrib><creatorcontrib>Lees, A.</creatorcontrib><creatorcontrib>Noyce, A.J.</creatorcontrib><creatorcontrib>Schrag, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagy, A.V.</au><au>Leschziner, G.</au><au>Eriksson, S.H.</au><au>Lees, A.</au><au>Noyce, A.J.</au><au>Schrag, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2023-04</date><risdate>2023</risdate><volume>109</volume><spage>105312</spage><epage>105312</epage><pages>105312-105312</pages><artnum>105312</artnum><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear.
Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group.
Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p < 0.001). The prevalence of MCI level I was 12.8% in the lower-risk, 21.9% in the higher-risk (within the highest 15th percentile) and 64% in RBD participants; 66% of RBD participants had MCI level II with multi-domain MCI, but particularly attention and memory deficits.
Cognitive impairment is increased in different groups at higher risk of PD, particularly in the subgroup formally diagnosed with RBD.
•People with increased risk scores for Parkinson's disease show reduced cognitive function.•There is a particularly high rate of cognitive impairment in patients with REM-sleep behaviour disorder.•These are present especially in the domains of attention and memory.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36827949</pmid><doi>10.1016/j.parkreldis.2023.105312</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9872-6680</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cognition Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Cognitive Dysfunction - psychology Epidemiology Humans Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson's disease Prodrome REM Sleep Behavior Disorder - diagnosis REM Sleep Behavior Disorder - epidemiology REM Sleep Behavior Disorder - etiology REM-Sleep behaviour disorder Risk Sleep |
| title | Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease |
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