Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease

Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, an...

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Veröffentlicht in:	Parkinsonism & related disorders 2023-04, Vol.109, p.105312-105312, Article 105312
Hauptverfasser:	Nagy, A.V., Leschziner, G., Eriksson, S.H., Lees, A., Noyce, A.J., Schrag, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cognition Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Cognitive Dysfunction - psychology Epidemiology Humans Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson's disease Prodrome REM Sleep Behavior Disorder - diagnosis REM Sleep Behavior Disorder - epidemiology REM Sleep Behavior Disorder - etiology REM-Sleep behaviour disorder Risk Sleep
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Zusammenfassung:	Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group. Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p
ISSN:	1353-8020 1873-5126
DOI:	10.1016/j.parkreldis.2023.105312