The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells

TRAP-1 OE cells exhibit metabolic rewiring. TRAP-1 OE cells enhance glutamine metabolism through HIF2α, SLC1A5, and GLS axis to fuel the TCA cycle upon glucose deprivation. Although a direct interaction of TRAP-1 with them is not observed in this study, we observed a correlation of this axis facilit...

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Veröffentlicht in:	Mitochondrion 2023-03, Vol.69, p.159-170
Hauptverfasser:	Dharaskar, Shrikant Purushottam, Amere Subbarao, Sreedhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Transport System ASC - metabolism Cancer Energy Metabolism Glucose - metabolism Glutamine Glutamine - metabolism Glycolysis HSP90 Heat-Shock Proteins - metabolism Humans Metabolism Minor Histocompatibility Antigens - metabolism Mitochondria Mitochondria - metabolism Molecular Chaperones - metabolism Neoplasms - metabolism TRAP-1
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