Validity of the Global Vascular Guidelines in Predicting Outcomes Based on First-Time Revascularization Strategy

The Global Vascular Guidelines (GVG) recommend selecting an endovascular versus open-surgical approach to revascularization for chronic limb-threatening ischemia (CLTI), based on the Global Limb Anatomic Staging System (GLASS) and wound, ischemia, and foot infection (WIfI) classification systems. We...

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Veröffentlicht in:Annals of vascular surgery 2023-09, Vol.95, p.142-153
Hauptverfasser: Lou, Vivian, Dossabhoy, Shernaz S., Tran, Kenneth, Yawary, Farishta, Ross, Elsie G., Stern, Jordan R., Dalman, Ronald L., Chandra, Venita
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container_end_page 153
container_issue
container_start_page 142
container_title Annals of vascular surgery
container_volume 95
creator Lou, Vivian
Dossabhoy, Shernaz S.
Tran, Kenneth
Yawary, Farishta
Ross, Elsie G.
Stern, Jordan R.
Dalman, Ronald L.
Chandra, Venita
description The Global Vascular Guidelines (GVG) recommend selecting an endovascular versus open-surgical approach to revascularization for chronic limb-threatening ischemia (CLTI), based on the Global Limb Anatomic Staging System (GLASS) and wound, ischemia, and foot infection (WIfI) classification systems. We assessed the utility of GVG-recommended strategies in predicting clinical outcomes. We conducted a single-center, retrospective review of first-time lower-extremity revascularizations within a comprehensive limb-preservation program from 2010 to 2018. Procedures were stratified by (1) treatment concordance with GVG-recommended strategy (concordant versus nonconcordant groups), (2) GLASS stages I-III, and (3) endovascular versus open strategies. The primary outcome was 5-year freedom from major adverse limb events (FF-MALE), defined as freedom from reintervention or major amputation, and secondary outcomes included 5-year overall survival, freedom from major amputation, freedom from reintervention, and immediate technical failure (ITF) during initial revascularization. Kaplan-Meier (KM) survival analysis and multivariate analysis with Cox proportional hazard models were performed on the primary and secondary outcomes. Of 281 first-time revascularizations for CLTI, 251 (89.3%) were endovascular and 186 (66.2%) were in the concordant group, with a mean clinical follow-up of 3.02 ± 2.40 years. Within the concordant group alone, 167 (89.8%) of revascularizations were endovascular. The concordant group had a higher rate of chronic kidney disease (60.8% vs. 45.3%, P = 0.02), WIfI foot infection grade (0.81 ± 1.1 vs. 0.56 ± 0.80, P = 0.03), and WIfI stage (3.1 ± 0.79 vs. 2.8 ± 1.2, P 
doi_str_mv 10.1016/j.avsg.2023.02.001
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We assessed the utility of GVG-recommended strategies in predicting clinical outcomes. We conducted a single-center, retrospective review of first-time lower-extremity revascularizations within a comprehensive limb-preservation program from 2010 to 2018. Procedures were stratified by (1) treatment concordance with GVG-recommended strategy (concordant versus nonconcordant groups), (2) GLASS stages I-III, and (3) endovascular versus open strategies. The primary outcome was 5-year freedom from major adverse limb events (FF-MALE), defined as freedom from reintervention or major amputation, and secondary outcomes included 5-year overall survival, freedom from major amputation, freedom from reintervention, and immediate technical failure (ITF) during initial revascularization. Kaplan-Meier (KM) survival analysis and multivariate analysis with Cox proportional hazard models were performed on the primary and secondary outcomes. Of 281 first-time revascularizations for CLTI, 251 (89.3%) were endovascular and 186 (66.2%) were in the concordant group, with a mean clinical follow-up of 3.02 ± 2.40 years. Within the concordant group alone, 167 (89.8%) of revascularizations were endovascular. The concordant group had a higher rate of chronic kidney disease (60.8% vs. 45.3%, P = 0.02), WIfI foot infection grade (0.81 ± 1.1 vs. 0.56 ± 0.80, P = 0.03), and WIfI stage (3.1 ± 0.79 vs. 2.8 ± 1.2, P &lt; 0.01) compared to the non-concordant group. After both KM and multivariate analyses, there were no significant differences in 5-year FF-MALE or overall survival between concordant and non-concordant groups. There was higher freedom from major amputation in the non-concordant group on KM analysis (83.9% vs. 74.2%, P = 0.025), though this difference was non-significant on multivariate analysis (hazard ratio [HR]: 0.49, 95% confidence interval [CI]: 0.21–1.15, P = 0.10). The open group had lower MALE compared to the endovascular group (HR: 0.39, 95% CI: 0.17–0.91, P = 0.029) attributed to a lower reintervention rate in the open group (HR: 0.31, 95% CI: 0.11–0.87, P = 0.026). GLASS stage was not associated with significant differences in outcomes, but the severity of GLASS stage was associated with ITF (2.1% in stage 1, 6.4% in stage 2, and 11.7% in stage 3, P = 0.01). In this study, CLTI treatment outcomes did not differ significantly based on whether treatment was received in concordance with GVG-recommended strategy. There was no difference in overall survival between the endovascular and open groups, though there was a higher reintervention rate in the endovascular group. The GVG guidelines are an important resource to help guide the management of CLTI patients. However, in this study, both concordance with GVG guidelines and GLASS staging were found to be indeterminate in differentiating outcomes between complex CLTI patients treated primarily with an endovascular-first approach. The revascularization approach for a CLTI patient is a nuanced decision that must take into account patient anatomy and clinical status, as well as physician skill and experience and institutional resources. •In 281 first-time revascularizations for chronic limb-threatening ischemia, whether treatment was concordant or nonconcordant with the Global Vascular Guidelines (GVG) recommended revascularization strategy (endovascular versus open) had no significant effect on freedom from 5-year major adverse limb events (45.3% vs. 50.7%) or overall survival (47.9% vs. 50.6%).•Treatment outcomes for chronic limb-threatening ischemia did not differ significantly based on whether treatment was received in concordance with GVG recommended strategy.•Further evaluation of GVG and optimal revascularization approach is required.</description><identifier>ISSN: 0890-5096</identifier><identifier>EISSN: 1615-5947</identifier><identifier>DOI: 10.1016/j.avsg.2023.02.001</identifier><identifier>PMID: 36828135</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Chronic Disease ; Chronic Limb-Threatening Ischemia ; Endovascular Procedures ; Humans ; Ischemia - diagnostic imaging ; Ischemia - surgery ; Limb Salvage - adverse effects ; Peripheral Arterial Disease - diagnostic imaging ; Peripheral Arterial Disease - surgery ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Annals of vascular surgery, 2023-09, Vol.95, p.142-153</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-285aca7539c43e92e7dbead5538f6fd099cee131ba36296aee081d47df3b69443</citedby><cites>FETCH-LOGICAL-c356t-285aca7539c43e92e7dbead5538f6fd099cee131ba36296aee081d47df3b69443</cites><orcidid>0000-0001-5047-3605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.avsg.2023.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36828135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lou, Vivian</creatorcontrib><creatorcontrib>Dossabhoy, Shernaz S.</creatorcontrib><creatorcontrib>Tran, Kenneth</creatorcontrib><creatorcontrib>Yawary, Farishta</creatorcontrib><creatorcontrib>Ross, Elsie G.</creatorcontrib><creatorcontrib>Stern, Jordan R.</creatorcontrib><creatorcontrib>Dalman, Ronald L.</creatorcontrib><creatorcontrib>Chandra, Venita</creatorcontrib><title>Validity of the Global Vascular Guidelines in Predicting Outcomes Based on First-Time Revascularization Strategy</title><title>Annals of vascular surgery</title><addtitle>Ann Vasc Surg</addtitle><description>The Global Vascular Guidelines (GVG) recommend selecting an endovascular versus open-surgical approach to revascularization for chronic limb-threatening ischemia (CLTI), based on the Global Limb Anatomic Staging System (GLASS) and wound, ischemia, and foot infection (WIfI) classification systems. We assessed the utility of GVG-recommended strategies in predicting clinical outcomes. We conducted a single-center, retrospective review of first-time lower-extremity revascularizations within a comprehensive limb-preservation program from 2010 to 2018. Procedures were stratified by (1) treatment concordance with GVG-recommended strategy (concordant versus nonconcordant groups), (2) GLASS stages I-III, and (3) endovascular versus open strategies. The primary outcome was 5-year freedom from major adverse limb events (FF-MALE), defined as freedom from reintervention or major amputation, and secondary outcomes included 5-year overall survival, freedom from major amputation, freedom from reintervention, and immediate technical failure (ITF) during initial revascularization. Kaplan-Meier (KM) survival analysis and multivariate analysis with Cox proportional hazard models were performed on the primary and secondary outcomes. Of 281 first-time revascularizations for CLTI, 251 (89.3%) were endovascular and 186 (66.2%) were in the concordant group, with a mean clinical follow-up of 3.02 ± 2.40 years. Within the concordant group alone, 167 (89.8%) of revascularizations were endovascular. The concordant group had a higher rate of chronic kidney disease (60.8% vs. 45.3%, P = 0.02), WIfI foot infection grade (0.81 ± 1.1 vs. 0.56 ± 0.80, P = 0.03), and WIfI stage (3.1 ± 0.79 vs. 2.8 ± 1.2, P &lt; 0.01) compared to the non-concordant group. After both KM and multivariate analyses, there were no significant differences in 5-year FF-MALE or overall survival between concordant and non-concordant groups. There was higher freedom from major amputation in the non-concordant group on KM analysis (83.9% vs. 74.2%, P = 0.025), though this difference was non-significant on multivariate analysis (hazard ratio [HR]: 0.49, 95% confidence interval [CI]: 0.21–1.15, P = 0.10). The open group had lower MALE compared to the endovascular group (HR: 0.39, 95% CI: 0.17–0.91, P = 0.029) attributed to a lower reintervention rate in the open group (HR: 0.31, 95% CI: 0.11–0.87, P = 0.026). GLASS stage was not associated with significant differences in outcomes, but the severity of GLASS stage was associated with ITF (2.1% in stage 1, 6.4% in stage 2, and 11.7% in stage 3, P = 0.01). In this study, CLTI treatment outcomes did not differ significantly based on whether treatment was received in concordance with GVG-recommended strategy. There was no difference in overall survival between the endovascular and open groups, though there was a higher reintervention rate in the endovascular group. The GVG guidelines are an important resource to help guide the management of CLTI patients. However, in this study, both concordance with GVG guidelines and GLASS staging were found to be indeterminate in differentiating outcomes between complex CLTI patients treated primarily with an endovascular-first approach. The revascularization approach for a CLTI patient is a nuanced decision that must take into account patient anatomy and clinical status, as well as physician skill and experience and institutional resources. •In 281 first-time revascularizations for chronic limb-threatening ischemia, whether treatment was concordant or nonconcordant with the Global Vascular Guidelines (GVG) recommended revascularization strategy (endovascular versus open) had no significant effect on freedom from 5-year major adverse limb events (45.3% vs. 50.7%) or overall survival (47.9% vs. 50.6%).•Treatment outcomes for chronic limb-threatening ischemia did not differ significantly based on whether treatment was received in concordance with GVG recommended strategy.•Further evaluation of GVG and optimal revascularization approach is required.</description><subject>Chronic Disease</subject><subject>Chronic Limb-Threatening Ischemia</subject><subject>Endovascular Procedures</subject><subject>Humans</subject><subject>Ischemia - diagnostic imaging</subject><subject>Ischemia - surgery</subject><subject>Limb Salvage - adverse effects</subject><subject>Peripheral Arterial Disease - diagnostic imaging</subject><subject>Peripheral Arterial Disease - surgery</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0890-5096</issn><issn>1615-5947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EomnpH-CAfOSyiz_WXlviAhUNSJWKoO3V8tqzwdF-BNsbKfz6OkrgyGmkmed9pXkQektJTQmVH7a13adNzQjjNWE1IfQFWlFJRSV0075EK6I0qQTR8gJdprQtAFONeo0uuFRMUS5WaPdkh-BDPuC5x_kX4PUwd3bATza5ZbARr5fgYQgTJBwm_D2CDy6HaYPvl-zmsaw_2wQezxO-DTHl6iGMgH_A_lwQ_tgcyvFnjjbD5vAGvertkOD6PK_Q4-2Xh5uv1d39-tvNp7vKcSFzxZSwzraCa9dw0Axa34H1QnDVy94TrR0A5bSzXDItLQBR1Det73knddPwK_T-1LuL8-8FUjZjSA6GwU4wL8mwVhHSCi1UQdkJdXFOKUJvdjGMNh4MJeZo2mzN0bQ5mjaEmSKyhN6d-5duBP8v8ldtAT6eAChf7gNEk1yAyRWBEVw2fg7_638G-b6RDA</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Lou, Vivian</creator><creator>Dossabhoy, Shernaz S.</creator><creator>Tran, Kenneth</creator><creator>Yawary, Farishta</creator><creator>Ross, Elsie G.</creator><creator>Stern, Jordan R.</creator><creator>Dalman, Ronald L.</creator><creator>Chandra, Venita</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5047-3605</orcidid></search><sort><creationdate>202309</creationdate><title>Validity of the Global Vascular Guidelines in Predicting Outcomes Based on First-Time Revascularization Strategy</title><author>Lou, Vivian ; 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We assessed the utility of GVG-recommended strategies in predicting clinical outcomes. We conducted a single-center, retrospective review of first-time lower-extremity revascularizations within a comprehensive limb-preservation program from 2010 to 2018. Procedures were stratified by (1) treatment concordance with GVG-recommended strategy (concordant versus nonconcordant groups), (2) GLASS stages I-III, and (3) endovascular versus open strategies. The primary outcome was 5-year freedom from major adverse limb events (FF-MALE), defined as freedom from reintervention or major amputation, and secondary outcomes included 5-year overall survival, freedom from major amputation, freedom from reintervention, and immediate technical failure (ITF) during initial revascularization. Kaplan-Meier (KM) survival analysis and multivariate analysis with Cox proportional hazard models were performed on the primary and secondary outcomes. Of 281 first-time revascularizations for CLTI, 251 (89.3%) were endovascular and 186 (66.2%) were in the concordant group, with a mean clinical follow-up of 3.02 ± 2.40 years. Within the concordant group alone, 167 (89.8%) of revascularizations were endovascular. The concordant group had a higher rate of chronic kidney disease (60.8% vs. 45.3%, P = 0.02), WIfI foot infection grade (0.81 ± 1.1 vs. 0.56 ± 0.80, P = 0.03), and WIfI stage (3.1 ± 0.79 vs. 2.8 ± 1.2, P &lt; 0.01) compared to the non-concordant group. After both KM and multivariate analyses, there were no significant differences in 5-year FF-MALE or overall survival between concordant and non-concordant groups. There was higher freedom from major amputation in the non-concordant group on KM analysis (83.9% vs. 74.2%, P = 0.025), though this difference was non-significant on multivariate analysis (hazard ratio [HR]: 0.49, 95% confidence interval [CI]: 0.21–1.15, P = 0.10). The open group had lower MALE compared to the endovascular group (HR: 0.39, 95% CI: 0.17–0.91, P = 0.029) attributed to a lower reintervention rate in the open group (HR: 0.31, 95% CI: 0.11–0.87, P = 0.026). GLASS stage was not associated with significant differences in outcomes, but the severity of GLASS stage was associated with ITF (2.1% in stage 1, 6.4% in stage 2, and 11.7% in stage 3, P = 0.01). In this study, CLTI treatment outcomes did not differ significantly based on whether treatment was received in concordance with GVG-recommended strategy. There was no difference in overall survival between the endovascular and open groups, though there was a higher reintervention rate in the endovascular group. The GVG guidelines are an important resource to help guide the management of CLTI patients. However, in this study, both concordance with GVG guidelines and GLASS staging were found to be indeterminate in differentiating outcomes between complex CLTI patients treated primarily with an endovascular-first approach. The revascularization approach for a CLTI patient is a nuanced decision that must take into account patient anatomy and clinical status, as well as physician skill and experience and institutional resources. •In 281 first-time revascularizations for chronic limb-threatening ischemia, whether treatment was concordant or nonconcordant with the Global Vascular Guidelines (GVG) recommended revascularization strategy (endovascular versus open) had no significant effect on freedom from 5-year major adverse limb events (45.3% vs. 50.7%) or overall survival (47.9% vs. 50.6%).•Treatment outcomes for chronic limb-threatening ischemia did not differ significantly based on whether treatment was received in concordance with GVG recommended strategy.•Further evaluation of GVG and optimal revascularization approach is required.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>36828135</pmid><doi>10.1016/j.avsg.2023.02.001</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5047-3605</orcidid></addata></record>
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subjects Chronic Disease
Chronic Limb-Threatening Ischemia
Endovascular Procedures
Humans
Ischemia - diagnostic imaging
Ischemia - surgery
Limb Salvage - adverse effects
Peripheral Arterial Disease - diagnostic imaging
Peripheral Arterial Disease - surgery
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
title Validity of the Global Vascular Guidelines in Predicting Outcomes Based on First-Time Revascularization Strategy
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