Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men
Purpose To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA). Methods Forty-five young physically active men were assessed for body composition, dietary nutrient intake...
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| Veröffentlicht in: | European journal of nutrition 2023-06, Vol.62 (4), p.1767-1782 |
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| creator | Papanikolaou, Konstantinos Jamurtas, Athanasios Z. Poulios, Athanasios Tsimeas, Panagiotis Draganidis, Dimitrios Margaritelis, Nikos V. Baloyiannis, Ioannis Papadopoulos, Constantinos Sovatzidis, Apostolos Deli, Chariklia K. Rosvoglou, Anastasia Georgakouli, Kalliopi Tzatzakis, Theofanis Nikolaidis, Michalis G. Fatouros, Ioannis G. |
| description | Purpose
To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA).
Methods
Forty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers.
Results
Dietary cysteine intake was positively correlated (
p
|
| doi_str_mv | 10.1007/s00394-023-03102-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2780069884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2815044980</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-528a184832cf87af7c2190c19889ea0c2bd23254ab33b4bc3a318bb3a82b884e3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQRiMEoqXwAiyQJTbdBMY_SZwlqqAgVWIBrC3HmTRuE-ficQp5Dl4YQ8pFYsHKI_l8Zyx_RfGcwysO0LwmANmqEoQsQXIQpXhQnHIl67IWvHp4nKE5KZ4Q3QBktOaPixNZa6FbVZ0WPz7d4oTJTmxeyU3IbOgZxi2NcXFbQhaxX74zSjatxDwxS7Q4bxP27JtPI-t9TseNuY0S-oDMh2Rvd89h3Mi77B58Ckg5H9iIdkrjxrZlDddHYtqYdcnfIZsxPC0eDXYifHZ_nhVf3r39fPG-vPp4-eHizVXpZFOlshLacq20FG7QjR0aJ3gLjrdat2jBia4XUlTKdlJ2qnPSSq67TlotOq0VyrPifPce4vJ1RUpm9uRwmmzAZSUjGg1QZ53K6Mt_0JtljSG_zgjNK1Cq1ZApsVMuLkQRB3OIfs6_YziYX5WZvTKTezC_KzMih17cq9duxv4Y-dNRBuQOUL4K1xj_7v6P9idAV6Qe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2815044980</pqid></control><display><type>article</type><title>Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Papanikolaou, Konstantinos ; Jamurtas, Athanasios Z. ; Poulios, Athanasios ; Tsimeas, Panagiotis ; Draganidis, Dimitrios ; Margaritelis, Nikos V. ; Baloyiannis, Ioannis ; Papadopoulos, Constantinos ; Sovatzidis, Apostolos ; Deli, Chariklia K. ; Rosvoglou, Anastasia ; Georgakouli, Kalliopi ; Tzatzakis, Theofanis ; Nikolaidis, Michalis G. ; Fatouros, Ioannis G.</creator><creatorcontrib>Papanikolaou, Konstantinos ; Jamurtas, Athanasios Z. ; Poulios, Athanasios ; Tsimeas, Panagiotis ; Draganidis, Dimitrios ; Margaritelis, Nikos V. ; Baloyiannis, Ioannis ; Papadopoulos, Constantinos ; Sovatzidis, Apostolos ; Deli, Chariklia K. ; Rosvoglou, Anastasia ; Georgakouli, Kalliopi ; Tzatzakis, Theofanis ; Nikolaidis, Michalis G. ; Fatouros, Ioannis G.</creatorcontrib><description>Purpose
To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA).
Methods
Forty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers.
Results
Dietary cysteine intake was positively correlated (
p
< 0.001) with both erythrocyte (
r
= 0.697) and muscle GSH (0.654,
p
< 0.001), erythrocyte reduced/oxidized glutathione ratio (GSH/GSSG) (
r
= 0.530,
p
= 0.001) and glutathione reductase (GR) activity (
r
= 0.352,
p
= 0.030) and inversely correlated with erythrocyte protein carbonyls (PC) levels (
r
= − 0.325;
p
= 0.046). Knee extensors eccentric peak torque was positively correlated with GR activity (
r
= 0.355;
p
= 0.031) while, one-repetition maximum in back squat exercise was positively correlated with erythrocyte GSH/GSSG ratio (
r
= 0.401;
p
= 0.014) and inversely correlated with erythrocyte GSSG and PC (
r
= − 0.441,
p
= 0.006;
r
= − 0.413,
p
= 0.011 respectively). Glutathione peroxidase (GPx) activity was positively correlated with step count (
r
= 0.520;
p
< 0.001), light (
r
= 0.406;
p
= 0.008), moderate (
r
= 0.417;
p
= 0.006), moderate-to-vigorous (
r
= 0.475;
p
= 0.001), vigorous (
r
= 0.352;
p
= 0.022) and very vigorous (
r
= 0.326;
p
= 0.035) PA. Muscle GSSG inversely correlated with light PA (
r
= − 0.353;
p
= 0.022).
Conclusion
These results indicate that dietary cysteine intake may be a critical element for the regulation of glutathione metabolism and redox status in two different tissues pinpointing the independent significance of cysteine for optimal redox regulation. Musculoskeletal fitness and PA levels may be predictors of skeletal muscle, but not erythrocyte, antioxidant capacity.
Trial registration
Registry: ClinicalTrials.gov, identifier: NCT03711838, date of registration: October 19, 2018.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-023-03102-2</identifier><identifier>PMID: 36828945</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antioxidants - metabolism ; Biomarkers ; Biomarkers - metabolism ; Body composition ; Chemistry ; Chemistry and Materials Science ; Correlation analysis ; Cysteine ; Dietary intake ; Eating ; Erythrocytes ; Exercise ; Glutathione - metabolism ; Glutathione Disulfide - metabolism ; Glutathione peroxidase ; Glutathione reductase ; Humans ; Male ; Muscle strength ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; NCT ; NCT03711838 ; Nutrition ; Original Contribution ; Oxidation-Reduction ; Oxidative Stress ; Physical activity ; Physical Fitness ; Skeletal muscle</subject><ispartof>European journal of nutrition, 2023-06, Vol.62 (4), p.1767-1782</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-528a184832cf87af7c2190c19889ea0c2bd23254ab33b4bc3a318bb3a82b884e3</citedby><cites>FETCH-LOGICAL-c375t-528a184832cf87af7c2190c19889ea0c2bd23254ab33b4bc3a318bb3a82b884e3</cites><orcidid>0000-0001-5115-9490 ; 0000-0002-6050-3000 ; 0000-0002-2773-7729 ; 0000-0002-5762-8419 ; 0000-0003-3912-0045 ; 0000-0001-5545-9271 ; 0000-0002-5062-9881 ; 0000-0002-2859-0845 ; 0000-0001-5243-4378 ; 0000-0002-5690-600X ; 0000-0002-8475-8411 ; 0000-0001-7633-5032 ; 0000-0001-5119-427X ; 0000-0001-5498-3119</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-023-03102-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-023-03102-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36828945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papanikolaou, Konstantinos</creatorcontrib><creatorcontrib>Jamurtas, Athanasios Z.</creatorcontrib><creatorcontrib>Poulios, Athanasios</creatorcontrib><creatorcontrib>Tsimeas, Panagiotis</creatorcontrib><creatorcontrib>Draganidis, Dimitrios</creatorcontrib><creatorcontrib>Margaritelis, Nikos V.</creatorcontrib><creatorcontrib>Baloyiannis, Ioannis</creatorcontrib><creatorcontrib>Papadopoulos, Constantinos</creatorcontrib><creatorcontrib>Sovatzidis, Apostolos</creatorcontrib><creatorcontrib>Deli, Chariklia K.</creatorcontrib><creatorcontrib>Rosvoglou, Anastasia</creatorcontrib><creatorcontrib>Georgakouli, Kalliopi</creatorcontrib><creatorcontrib>Tzatzakis, Theofanis</creatorcontrib><creatorcontrib>Nikolaidis, Michalis G.</creatorcontrib><creatorcontrib>Fatouros, Ioannis G.</creatorcontrib><title>Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA).
Methods
Forty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers.
Results
Dietary cysteine intake was positively correlated (
p
< 0.001) with both erythrocyte (
r
= 0.697) and muscle GSH (0.654,
p
< 0.001), erythrocyte reduced/oxidized glutathione ratio (GSH/GSSG) (
r
= 0.530,
p
= 0.001) and glutathione reductase (GR) activity (
r
= 0.352,
p
= 0.030) and inversely correlated with erythrocyte protein carbonyls (PC) levels (
r
= − 0.325;
p
= 0.046). Knee extensors eccentric peak torque was positively correlated with GR activity (
r
= 0.355;
p
= 0.031) while, one-repetition maximum in back squat exercise was positively correlated with erythrocyte GSH/GSSG ratio (
r
= 0.401;
p
= 0.014) and inversely correlated with erythrocyte GSSG and PC (
r
= − 0.441,
p
= 0.006;
r
= − 0.413,
p
= 0.011 respectively). Glutathione peroxidase (GPx) activity was positively correlated with step count (
r
= 0.520;
p
< 0.001), light (
r
= 0.406;
p
= 0.008), moderate (
r
= 0.417;
p
= 0.006), moderate-to-vigorous (
r
= 0.475;
p
= 0.001), vigorous (
r
= 0.352;
p
= 0.022) and very vigorous (
r
= 0.326;
p
= 0.035) PA. Muscle GSSG inversely correlated with light PA (
r
= − 0.353;
p
= 0.022).
Conclusion
These results indicate that dietary cysteine intake may be a critical element for the regulation of glutathione metabolism and redox status in two different tissues pinpointing the independent significance of cysteine for optimal redox regulation. Musculoskeletal fitness and PA levels may be predictors of skeletal muscle, but not erythrocyte, antioxidant capacity.
Trial registration
Registry: ClinicalTrials.gov, identifier: NCT03711838, date of registration: October 19, 2018.</description><subject>Antioxidants - metabolism</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Body composition</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Correlation analysis</subject><subject>Cysteine</subject><subject>Dietary intake</subject><subject>Eating</subject><subject>Erythrocytes</subject><subject>Exercise</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Disulfide - metabolism</subject><subject>Glutathione peroxidase</subject><subject>Glutathione reductase</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle strength</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>NCT</subject><subject>NCT03711838</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Physical activity</subject><subject>Physical Fitness</subject><subject>Skeletal 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Dimitrios</creator><creator>Margaritelis, Nikos V.</creator><creator>Baloyiannis, Ioannis</creator><creator>Papadopoulos, Constantinos</creator><creator>Sovatzidis, Apostolos</creator><creator>Deli, Chariklia K.</creator><creator>Rosvoglou, Anastasia</creator><creator>Georgakouli, Kalliopi</creator><creator>Tzatzakis, Theofanis</creator><creator>Nikolaidis, Michalis G.</creator><creator>Fatouros, Ioannis G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature 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muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men</title><author>Papanikolaou, Konstantinos ; Jamurtas, Athanasios Z. ; Poulios, Athanasios ; Tsimeas, Panagiotis ; Draganidis, Dimitrios ; Margaritelis, Nikos V. ; Baloyiannis, Ioannis ; Papadopoulos, Constantinos ; Sovatzidis, Apostolos ; Deli, Chariklia K. ; Rosvoglou, Anastasia ; Georgakouli, Kalliopi ; Tzatzakis, Theofanis ; Nikolaidis, Michalis G. ; Fatouros, Ioannis G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-528a184832cf87af7c2190c19889ea0c2bd23254ab33b4bc3a318bb3a82b884e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants - metabolism</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Body composition</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Correlation analysis</topic><topic>Cysteine</topic><topic>Dietary intake</topic><topic>Eating</topic><topic>Erythrocytes</topic><topic>Exercise</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Disulfide - metabolism</topic><topic>Glutathione peroxidase</topic><topic>Glutathione reductase</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle strength</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Musculoskeletal system</topic><topic>NCT</topic><topic>NCT03711838</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Physical activity</topic><topic>Physical Fitness</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papanikolaou, Konstantinos</creatorcontrib><creatorcontrib>Jamurtas, Athanasios Z.</creatorcontrib><creatorcontrib>Poulios, Athanasios</creatorcontrib><creatorcontrib>Tsimeas, Panagiotis</creatorcontrib><creatorcontrib>Draganidis, Dimitrios</creatorcontrib><creatorcontrib>Margaritelis, Nikos V.</creatorcontrib><creatorcontrib>Baloyiannis, Ioannis</creatorcontrib><creatorcontrib>Papadopoulos, Constantinos</creatorcontrib><creatorcontrib>Sovatzidis, Apostolos</creatorcontrib><creatorcontrib>Deli, Chariklia K.</creatorcontrib><creatorcontrib>Rosvoglou, Anastasia</creatorcontrib><creatorcontrib>Georgakouli, Kalliopi</creatorcontrib><creatorcontrib>Tzatzakis, Theofanis</creatorcontrib><creatorcontrib>Nikolaidis, Michalis G.</creatorcontrib><creatorcontrib>Fatouros, Ioannis G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papanikolaou, Konstantinos</au><au>Jamurtas, Athanasios Z.</au><au>Poulios, Athanasios</au><au>Tsimeas, Panagiotis</au><au>Draganidis, Dimitrios</au><au>Margaritelis, Nikos V.</au><au>Baloyiannis, Ioannis</au><au>Papadopoulos, Constantinos</au><au>Sovatzidis, Apostolos</au><au>Deli, Chariklia K.</au><au>Rosvoglou, Anastasia</au><au>Georgakouli, Kalliopi</au><au>Tzatzakis, Theofanis</au><au>Nikolaidis, Michalis G.</au><au>Fatouros, Ioannis G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>62</volume><issue>4</issue><spage>1767</spage><epage>1782</epage><pages>1767-1782</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA).
Methods
Forty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers.
Results
Dietary cysteine intake was positively correlated (
p
< 0.001) with both erythrocyte (
r
= 0.697) and muscle GSH (0.654,
p
< 0.001), erythrocyte reduced/oxidized glutathione ratio (GSH/GSSG) (
r
= 0.530,
p
= 0.001) and glutathione reductase (GR) activity (
r
= 0.352,
p
= 0.030) and inversely correlated with erythrocyte protein carbonyls (PC) levels (
r
= − 0.325;
p
= 0.046). Knee extensors eccentric peak torque was positively correlated with GR activity (
r
= 0.355;
p
= 0.031) while, one-repetition maximum in back squat exercise was positively correlated with erythrocyte GSH/GSSG ratio (
r
= 0.401;
p
= 0.014) and inversely correlated with erythrocyte GSSG and PC (
r
= − 0.441,
p
= 0.006;
r
= − 0.413,
p
= 0.011 respectively). Glutathione peroxidase (GPx) activity was positively correlated with step count (
r
= 0.520;
p
< 0.001), light (
r
= 0.406;
p
= 0.008), moderate (
r
= 0.417;
p
= 0.006), moderate-to-vigorous (
r
= 0.475;
p
= 0.001), vigorous (
r
= 0.352;
p
= 0.022) and very vigorous (
r
= 0.326;
p
= 0.035) PA. Muscle GSSG inversely correlated with light PA (
r
= − 0.353;
p
= 0.022).
Conclusion
These results indicate that dietary cysteine intake may be a critical element for the regulation of glutathione metabolism and redox status in two different tissues pinpointing the independent significance of cysteine for optimal redox regulation. Musculoskeletal fitness and PA levels may be predictors of skeletal muscle, but not erythrocyte, antioxidant capacity.
Trial registration
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| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2023-06, Vol.62 (4), p.1767-1782 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2780069884 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Antioxidants - metabolism Biomarkers Biomarkers - metabolism Body composition Chemistry Chemistry and Materials Science Correlation analysis Cysteine Dietary intake Eating Erythrocytes Exercise Glutathione - metabolism Glutathione Disulfide - metabolism Glutathione peroxidase Glutathione reductase Humans Male Muscle strength Muscle, Skeletal - metabolism Musculoskeletal system NCT NCT03711838 Nutrition Original Contribution Oxidation-Reduction Oxidative Stress Physical activity Physical Fitness Skeletal muscle |
| title | Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men |
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