ASCs Activate cGAS-Type I IFNs-IL-7 Axis Via Pseudomonas aeruginosa-Derived Outer Membrane Vesicles to Resolve Pneumonia

Abstract Mesenchymal stem cells (MSCs) therapy could efficiently attenuate LPS-induced acute lung injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the underlying molecular mechanisms are still elusive. Here, we report that PA-derived outer membrane vesicles (OMVs) trigger mou...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2023-05, Vol.41 (5), p.468-481
Hauptverfasser:	Di, Caixia, Jiang, Yanshan, Li, Lulu, Shi, Mengmeng, Zhu, Yinggang, Zhang, Jing, Song, Yuanlin, Su, Xiao, Qu, Jieming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - metabolism Interferon Type I - metabolism Interleukin-7 Membrane Proteins - genetics Mice Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Pneumonia - therapy Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism
Online-Zugang:	Volltext
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