The role of magnetic resonance imaging in the diagnostic work-out of myopathies: differential diagnosis between inflammatory myopathies and muscular dystrophies
The differential diagnosis between idiopathic inflammatory myopathies (IIM) and muscular dystrophies (MD) may be challenging. We analysed the potential role of muscular magnetic resonance imaging (MRI) in the differential diagnosis between IIM and MD. MRI of patients (91 IIM and 43 MD), studied with...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2023-03, Vol.41 (2), p.301-308 |
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| creator | Barsotti, Simone Aringhieri, Giacomo Mugellini, Barbara Torri, Francesca Minichilli, Fabrizio Tripoli, Alessandra Cardelli, Chiara Cioffi, Elisa Zampa, Virna Siciliano, Gabriele Caramella, Davide Ricci, Giulia Mosca, Marta |
| description | The differential diagnosis between idiopathic inflammatory myopathies (IIM) and muscular dystrophies (MD) may be challenging. We analysed the potential role of muscular magnetic resonance imaging (MRI) in the differential diagnosis between IIM and MD.
MRI of patients (91 IIM and 43 MD), studied with a standardised protocol, have been collected. The presence of oedema, muscular atrophy and intramuscular adipose changes were evaluated. Moreover, we computed a composite score for each MRI item to better discriminate between the two diseases.
Oedema was significantly more prevalent in IIM compared with MD in pelvis muscles (p |
| doi_str_mv | 10.55563/clinexprheumatol/dkmz6o |
| format | Article |
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MRI of patients (91 IIM and 43 MD), studied with a standardised protocol, have been collected. The presence of oedema, muscular atrophy and intramuscular adipose changes were evaluated. Moreover, we computed a composite score for each MRI item to better discriminate between the two diseases.
Oedema was significantly more prevalent in IIM compared with MD in pelvis muscles (p<0.001), anterior lodge and medial lodges (p=0.044) of the thighs. Adipose infiltration/substitution and muscular atrophy were more prevalent in MD, in particular adipose tissue was prevalent in all the compartments of the thighs (p<0.05), atrophy was prevalent at the thighs and pelvis muscles (p<0.001). The probability of IIM increased with higher oedema score and decreased with higher atrophy and intramuscular adipose infiltration/substitution scores.
A different distribution of muscular involvement between IIM and MD has been identified. Muscular MRI may be useful in the differential diagnosis, potentially reducing the number of muscular biopsies that may be reserved only for doubtful cases.</description><identifier>ISSN: 0392-856X</identifier><identifier>ISSN: 1593-098X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>DOI: 10.55563/clinexprheumatol/dkmz6o</identifier><identifier>PMID: 36826782</identifier><language>eng</language><publisher>Italy</publisher><subject>Diagnosis, Differential ; Edema ; Humans ; Magnetic Resonance Imaging - methods ; Muscle, Skeletal - pathology ; Muscular Atrophy - diagnosis ; Muscular Atrophy - pathology ; Muscular Diseases - diagnosis ; Muscular Dystrophies - diagnosis ; Muscular Dystrophies - pathology ; Myositis - diagnosis</subject><ispartof>Clinical and experimental rheumatology, 2023-03, Vol.41 (2), p.301-308</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-f5c7c25a693101e7ad3e73e401502d76b3fb46cae69a2043b9d65b15a091feac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36826782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barsotti, Simone</creatorcontrib><creatorcontrib>Aringhieri, Giacomo</creatorcontrib><creatorcontrib>Mugellini, Barbara</creatorcontrib><creatorcontrib>Torri, Francesca</creatorcontrib><creatorcontrib>Minichilli, Fabrizio</creatorcontrib><creatorcontrib>Tripoli, Alessandra</creatorcontrib><creatorcontrib>Cardelli, Chiara</creatorcontrib><creatorcontrib>Cioffi, Elisa</creatorcontrib><creatorcontrib>Zampa, Virna</creatorcontrib><creatorcontrib>Siciliano, Gabriele</creatorcontrib><creatorcontrib>Caramella, Davide</creatorcontrib><creatorcontrib>Ricci, Giulia</creatorcontrib><creatorcontrib>Mosca, Marta</creatorcontrib><title>The role of magnetic resonance imaging in the diagnostic work-out of myopathies: differential diagnosis between inflammatory myopathies and muscular dystrophies</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>The differential diagnosis between idiopathic inflammatory myopathies (IIM) and muscular dystrophies (MD) may be challenging. We analysed the potential role of muscular magnetic resonance imaging (MRI) in the differential diagnosis between IIM and MD.
MRI of patients (91 IIM and 43 MD), studied with a standardised protocol, have been collected. The presence of oedema, muscular atrophy and intramuscular adipose changes were evaluated. Moreover, we computed a composite score for each MRI item to better discriminate between the two diseases.
Oedema was significantly more prevalent in IIM compared with MD in pelvis muscles (p<0.001), anterior lodge and medial lodges (p=0.044) of the thighs. Adipose infiltration/substitution and muscular atrophy were more prevalent in MD, in particular adipose tissue was prevalent in all the compartments of the thighs (p<0.05), atrophy was prevalent at the thighs and pelvis muscles (p<0.001). The probability of IIM increased with higher oedema score and decreased with higher atrophy and intramuscular adipose infiltration/substitution scores.
A different distribution of muscular involvement between IIM and MD has been identified. Muscular MRI may be useful in the differential diagnosis, potentially reducing the number of muscular biopsies that may be reserved only for doubtful cases.</description><subject>Diagnosis, Differential</subject><subject>Edema</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Atrophy - diagnosis</subject><subject>Muscular Atrophy - pathology</subject><subject>Muscular Diseases - diagnosis</subject><subject>Muscular Dystrophies - diagnosis</subject><subject>Muscular Dystrophies - pathology</subject><subject>Myositis - diagnosis</subject><issn>0392-856X</issn><issn>1593-098X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9KxDAQxoMo7rr6CpKjl7pp06StN1n8B4IXBW8lTSe70TSpSYquT-Oj2nVVxNPAzO_7ZpgPIZySU8YYp3NptIW33q9g6ER0Zt4-d-_c7aBpyiqakKp83EVTQqssKRl_nKCDEJ4IyTjjxT6aUF5mvCizKfq4XwH2zgB2CndiaSFqiT0EZ4WVgPXY03aJtcVxJFs9Ii5smFfnnxM3xC_h2vUirjSEsxFRCjzYqIX54XXADcRXADsaKSO6zdF-_UeHhW1xNwQ5GOFxuw7Ru34zOER7SpgAR991hh4uL-4X18nt3dXN4vw2kZSzmCgmC5kxwSuakhQK0VIoKOQkZSRrC95Q1eRcCuCVyEhOm6rlrEmZIFWqQEg6Qydb3967lwFCrDsdJBgjLLgh1FlREsKrvMxHtNyi0rsQPKi69-Of_LpOSf2VT_0_n3qbzyg9_t4yNB20v8KfQOgnaUmZuQ</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Barsotti, Simone</creator><creator>Aringhieri, Giacomo</creator><creator>Mugellini, Barbara</creator><creator>Torri, Francesca</creator><creator>Minichilli, Fabrizio</creator><creator>Tripoli, Alessandra</creator><creator>Cardelli, Chiara</creator><creator>Cioffi, Elisa</creator><creator>Zampa, Virna</creator><creator>Siciliano, Gabriele</creator><creator>Caramella, Davide</creator><creator>Ricci, Giulia</creator><creator>Mosca, Marta</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>The role of magnetic resonance imaging in the diagnostic work-out of myopathies: differential diagnosis between inflammatory myopathies and muscular dystrophies</title><author>Barsotti, Simone ; Aringhieri, Giacomo ; Mugellini, Barbara ; Torri, Francesca ; Minichilli, Fabrizio ; Tripoli, Alessandra ; Cardelli, Chiara ; Cioffi, Elisa ; Zampa, Virna ; Siciliano, Gabriele ; Caramella, Davide ; Ricci, Giulia ; Mosca, Marta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-f5c7c25a693101e7ad3e73e401502d76b3fb46cae69a2043b9d65b15a091feac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diagnosis, Differential</topic><topic>Edema</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Atrophy - diagnosis</topic><topic>Muscular Atrophy - pathology</topic><topic>Muscular Diseases - diagnosis</topic><topic>Muscular Dystrophies - diagnosis</topic><topic>Muscular Dystrophies - pathology</topic><topic>Myositis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barsotti, Simone</creatorcontrib><creatorcontrib>Aringhieri, Giacomo</creatorcontrib><creatorcontrib>Mugellini, Barbara</creatorcontrib><creatorcontrib>Torri, Francesca</creatorcontrib><creatorcontrib>Minichilli, Fabrizio</creatorcontrib><creatorcontrib>Tripoli, Alessandra</creatorcontrib><creatorcontrib>Cardelli, Chiara</creatorcontrib><creatorcontrib>Cioffi, Elisa</creatorcontrib><creatorcontrib>Zampa, Virna</creatorcontrib><creatorcontrib>Siciliano, Gabriele</creatorcontrib><creatorcontrib>Caramella, Davide</creatorcontrib><creatorcontrib>Ricci, Giulia</creatorcontrib><creatorcontrib>Mosca, Marta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barsotti, Simone</au><au>Aringhieri, Giacomo</au><au>Mugellini, Barbara</au><au>Torri, Francesca</au><au>Minichilli, Fabrizio</au><au>Tripoli, Alessandra</au><au>Cardelli, Chiara</au><au>Cioffi, Elisa</au><au>Zampa, Virna</au><au>Siciliano, Gabriele</au><au>Caramella, Davide</au><au>Ricci, Giulia</au><au>Mosca, Marta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of magnetic resonance imaging in the diagnostic work-out of myopathies: differential diagnosis between inflammatory myopathies and muscular dystrophies</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2023-03</date><risdate>2023</risdate><volume>41</volume><issue>2</issue><spage>301</spage><epage>308</epage><pages>301-308</pages><issn>0392-856X</issn><issn>1593-098X</issn><eissn>1593-098X</eissn><abstract>The differential diagnosis between idiopathic inflammatory myopathies (IIM) and muscular dystrophies (MD) may be challenging. We analysed the potential role of muscular magnetic resonance imaging (MRI) in the differential diagnosis between IIM and MD.
MRI of patients (91 IIM and 43 MD), studied with a standardised protocol, have been collected. The presence of oedema, muscular atrophy and intramuscular adipose changes were evaluated. Moreover, we computed a composite score for each MRI item to better discriminate between the two diseases.
Oedema was significantly more prevalent in IIM compared with MD in pelvis muscles (p<0.001), anterior lodge and medial lodges (p=0.044) of the thighs. Adipose infiltration/substitution and muscular atrophy were more prevalent in MD, in particular adipose tissue was prevalent in all the compartments of the thighs (p<0.05), atrophy was prevalent at the thighs and pelvis muscles (p<0.001). The probability of IIM increased with higher oedema score and decreased with higher atrophy and intramuscular adipose infiltration/substitution scores.
A different distribution of muscular involvement between IIM and MD has been identified. Muscular MRI may be useful in the differential diagnosis, potentially reducing the number of muscular biopsies that may be reserved only for doubtful cases.</abstract><cop>Italy</cop><pmid>36826782</pmid><doi>10.55563/clinexprheumatol/dkmz6o</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Diagnosis, Differential Edema Humans Magnetic Resonance Imaging - methods Muscle, Skeletal - pathology Muscular Atrophy - diagnosis Muscular Atrophy - pathology Muscular Diseases - diagnosis Muscular Dystrophies - diagnosis Muscular Dystrophies - pathology Myositis - diagnosis |
| title | The role of magnetic resonance imaging in the diagnostic work-out of myopathies: differential diagnosis between inflammatory myopathies and muscular dystrophies |
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