Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)
Abstract Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI 2 years.
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| Veröffentlicht in: | Clinical infectious diseases 2023-06, Vol.76 (11), p.2010-2013 |
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| container_end_page | 2013 |
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| container_issue | 11 |
| container_start_page | 2010 |
| container_title | Clinical infectious diseases |
| container_volume | 76 |
| creator | Kileel, Emma M Malvestutto, Carlos D Lo, Janet Fitch, Kathleen V Fichtenbaum, Carl J Aberg, Judith A Zanni, Markella V Martinez, Esteban Okeke, Nwora Lance Kumar, Princy Joao, Esau Bares, Sara H Berrner, Daniel Smieja, Marek Roa, Jhoanna C McCallum, Sara Douglas, Pamela S Ribaudo, Heather J Grinspoon, Steven K |
| description | Abstract
Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI 2 years. |
| doi_str_mv | 10.1093/cid/ciad107 |
| format | Article |
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Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .01), but not those on an entry INSTI >2 years.</description><identifier>ISSN: 1058-4838</identifier><identifier>ISSN: 1537-6591</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciad107</identifier><identifier>PMID: 36825498</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Body Mass Index ; Drug Resistance, Viral ; HIV Infections - drug therapy ; HIV Infections - prevention & control ; HIV Integrase ; HIV Integrase Inhibitors - pharmacology ; HIV Integrase Inhibitors - therapeutic use ; HIV-1 ; Humans</subject><ispartof>Clinical infectious diseases, 2023-06, Vol.76 (11), p.2010-2013</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c235t-dbcc812c60efc59da749e3bdb361476d618cb2c22338a718bb7d2c85a79f30443</citedby><cites>FETCH-LOGICAL-c235t-dbcc812c60efc59da749e3bdb361476d618cb2c22338a718bb7d2c85a79f30443</cites><orcidid>0000-0003-4456-0176 ; 0000-0002-2130-2505 ; 0000-0003-3156-2965 ; 0000-0002-5678-6140 ; 0000-0002-4711-3956 ; 0000-0001-9876-4049 ; 0000-0002-0541-3707</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36825498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kileel, Emma M</creatorcontrib><creatorcontrib>Malvestutto, Carlos D</creatorcontrib><creatorcontrib>Lo, Janet</creatorcontrib><creatorcontrib>Fitch, Kathleen V</creatorcontrib><creatorcontrib>Fichtenbaum, Carl J</creatorcontrib><creatorcontrib>Aberg, Judith A</creatorcontrib><creatorcontrib>Zanni, Markella V</creatorcontrib><creatorcontrib>Martinez, Esteban</creatorcontrib><creatorcontrib>Okeke, Nwora Lance</creatorcontrib><creatorcontrib>Kumar, Princy</creatorcontrib><creatorcontrib>Joao, Esau</creatorcontrib><creatorcontrib>Bares, Sara H</creatorcontrib><creatorcontrib>Berrner, Daniel</creatorcontrib><creatorcontrib>Smieja, Marek</creatorcontrib><creatorcontrib>Roa, Jhoanna C</creatorcontrib><creatorcontrib>McCallum, Sara</creatorcontrib><creatorcontrib>Douglas, Pamela S</creatorcontrib><creatorcontrib>Ribaudo, Heather J</creatorcontrib><creatorcontrib>Grinspoon, Steven K</creatorcontrib><title>Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .01), but not those on an entry INSTI >2 years.</description><subject>Body Mass Index</subject><subject>Drug Resistance, Viral</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Integrase</subject><subject>HIV Integrase Inhibitors - pharmacology</subject><subject>HIV Integrase Inhibitors - therapeutic use</subject><subject>HIV-1</subject><subject>Humans</subject><issn>1058-4838</issn><issn>1537-6591</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhiNERS-wYo_OCrVCATvOxWE3DGk70iCqUTvbyLFPOkaJPdgOMDwfD1a3M7Bkce6ffh3pT5LXlLynpGYfpFYxhKKkepac0IJVaVnU9HnsScHTnDN-nJx6_40QSjkpXiTHrORZkdf8JPkz3whzjx60gU9W7eCL8B4WRuEv-KnDBpY2nl0a0I1xHfDeCY-x2-hOB-vgzuNHmD1hOkxKGzHALKad1x5sD59FENA7O0LYIKyEUXbUv1HBrdMRDRZuHP5AE2AtvJwG4aB5HJ8-up5GYWAxjpOxCnstNRq5g7V2k4fzVXOzWjTr5uJlctSLweOrQz1L7i6b2_l1uvx6tZjPlqnMWBFS1UnJaSZLgr0saiWqvEbWqY6VNK9KVVIuu0xmGWNcVJR3XaUyyQtR1T0jec7OkvO97tbZ7xP60I7aSxwGYdBOvs0qTkhZE04j-m6PSme9d9i3W6dH4XYtJe2jbW20rT3YFuk3B-GpG1H9Y__6FIG3e8BO2_8qPQDc1aNF</recordid><startdate>20230608</startdate><enddate>20230608</enddate><creator>Kileel, Emma M</creator><creator>Malvestutto, Carlos D</creator><creator>Lo, Janet</creator><creator>Fitch, Kathleen V</creator><creator>Fichtenbaum, Carl J</creator><creator>Aberg, Judith A</creator><creator>Zanni, Markella V</creator><creator>Martinez, Esteban</creator><creator>Okeke, Nwora Lance</creator><creator>Kumar, Princy</creator><creator>Joao, Esau</creator><creator>Bares, Sara H</creator><creator>Berrner, Daniel</creator><creator>Smieja, Marek</creator><creator>Roa, Jhoanna C</creator><creator>McCallum, Sara</creator><creator>Douglas, Pamela S</creator><creator>Ribaudo, Heather J</creator><creator>Grinspoon, Steven K</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4456-0176</orcidid><orcidid>https://orcid.org/0000-0002-2130-2505</orcidid><orcidid>https://orcid.org/0000-0003-3156-2965</orcidid><orcidid>https://orcid.org/0000-0002-5678-6140</orcidid><orcidid>https://orcid.org/0000-0002-4711-3956</orcidid><orcidid>https://orcid.org/0000-0001-9876-4049</orcidid><orcidid>https://orcid.org/0000-0002-0541-3707</orcidid></search><sort><creationdate>20230608</creationdate><title>Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)</title><author>Kileel, Emma M ; 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Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .01), but not those on an entry INSTI >2 years.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36825498</pmid><doi>10.1093/cid/ciad107</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-4456-0176</orcidid><orcidid>https://orcid.org/0000-0002-2130-2505</orcidid><orcidid>https://orcid.org/0000-0003-3156-2965</orcidid><orcidid>https://orcid.org/0000-0002-5678-6140</orcidid><orcidid>https://orcid.org/0000-0002-4711-3956</orcidid><orcidid>https://orcid.org/0000-0001-9876-4049</orcidid><orcidid>https://orcid.org/0000-0002-0541-3707</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2023-06, Vol.76 (11), p.2010-2013 |
| issn | 1058-4838 1537-6591 1537-6591 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Body Mass Index Drug Resistance, Viral HIV Infections - drug therapy HIV Infections - prevention & control HIV Integrase HIV Integrase Inhibitors - pharmacology HIV Integrase Inhibitors - therapeutic use HIV-1 Humans |
| title | Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE) |
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