Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion
Objective Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature. Methods We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman. Results FNA smears of hemorr...
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| Veröffentlicht in: | Cytopathology (Oxford) 2023-07, Vol.34 (4), p.334-336 |
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| container_title | Cytopathology (Oxford) |
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| creator | Challa, Bindu S. Wakely, Paul E. |
| description | Objective
Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature.
Methods
We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman.
Results
FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3‐20 μm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A.
Conclusions
HS is a rare lesion that occurs post‐subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.
Haemoglobin spherulosis is a rare cytological finding that occurs secondary to vitreous haemorrhage. Spherical globules composed of haemoglobin A appear as smooth, rounded, slightly refractile ‘beads’ in cytocentrifugation smears. |
| doi_str_mv | 10.1111/cyt.13223 |
| format | Article |
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Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature.
Methods
We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman.
Results
FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3‐20 μm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A.
Conclusions
HS is a rare lesion that occurs post‐subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.
Haemoglobin spherulosis is a rare cytological finding that occurs secondary to vitreous haemorrhage. Spherical globules composed of haemoglobin A appear as smooth, rounded, slightly refractile ‘beads’ in cytocentrifugation smears.</description><identifier>ISSN: 0956-5507</identifier><identifier>EISSN: 1365-2303</identifier><identifier>DOI: 10.1111/cyt.13223</identifier><identifier>PMID: 36825891</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Biopsy ; Biopsy, Fine-Needle ; Cytopathology ; Female ; fine needle ; haemoglobin spherulosis ; Hemoglobin ; Hemoglobins ; Hemorrhage ; Humans ; Lesions ; Lymphocytes ; Spherules ; vitreous fluid</subject><ispartof>Cytopathology (Oxford), 2023-07, Vol.34 (4), p.334-336</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><rights>Copyright © 2023 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3133-2a7e1d2813e93945842e7e7b01942e224166d889b4b77bcc0c879de117436c0d3</cites><orcidid>0000-0002-0531-2690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcyt.13223$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcyt.13223$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36825891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Challa, Bindu S.</creatorcontrib><creatorcontrib>Wakely, Paul E.</creatorcontrib><title>Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion</title><title>Cytopathology (Oxford)</title><addtitle>Cytopathology</addtitle><description>Objective
Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature.
Methods
We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman.
Results
FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3‐20 μm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A.
Conclusions
HS is a rare lesion that occurs post‐subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.
Haemoglobin spherulosis is a rare cytological finding that occurs secondary to vitreous haemorrhage. Spherical globules composed of haemoglobin A appear as smooth, rounded, slightly refractile ‘beads’ in cytocentrifugation smears.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Biopsy, Fine-Needle</subject><subject>Cytopathology</subject><subject>Female</subject><subject>fine needle</subject><subject>haemoglobin spherulosis</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Lesions</subject><subject>Lymphocytes</subject><subject>Spherules</subject><subject>vitreous fluid</subject><issn>0956-5507</issn><issn>1365-2303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtKBDEUBuAgiq6XwheQgI0Wo7nMTBI7WbyBIIgWViGTOauR7GRMNsi-vdFVC8HTnFN8_Bx-hPYpOaFlTu1ycUI5Y3wNTShvm4pxwtfRhKimrZqGiC20ndIrIZQpxjfRFm8la6SiE3R_bWAenn3o3IDT-AIx-5BcOsOXbgA8APQesEmji2bhwoA7F8a0xGGGzYDzkFM2HgebvYnYQypkF23MjE-w97130OPlxcP0urq9u7qZnt9WllPOK2YE0J5JykFxVTeyZiBAdISqcjFW07btpVRd3QnRWUusFKoHSkXNW0t6voOOVrljDG8Z0kLPXbLgvRkg5KSZkIS0krSq0MM_9DXkOJTvNJOMy0ZQwoo6XikbQ0oRZnqMbm7iUlOiP4vWpWj9VXSxB9-JuZtD_yt_mi3gdAXenYfl_0l6-vSwivwAhKuF_g</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Challa, Bindu S.</creator><creator>Wakely, Paul E.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0531-2690</orcidid></search><sort><creationdate>202307</creationdate><title>Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion</title><author>Challa, Bindu S. ; Wakely, Paul E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3133-2a7e1d2813e93945842e7e7b01942e224166d889b4b77bcc0c879de117436c0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Biopsy</topic><topic>Biopsy, Fine-Needle</topic><topic>Cytopathology</topic><topic>Female</topic><topic>fine needle</topic><topic>haemoglobin spherulosis</topic><topic>Hemoglobin</topic><topic>Hemoglobins</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Lesions</topic><topic>Lymphocytes</topic><topic>Spherules</topic><topic>vitreous fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Challa, Bindu S.</creatorcontrib><creatorcontrib>Wakely, Paul E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cytopathology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Challa, Bindu S.</au><au>Wakely, Paul E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion</atitle><jtitle>Cytopathology (Oxford)</jtitle><addtitle>Cytopathology</addtitle><date>2023-07</date><risdate>2023</risdate><volume>34</volume><issue>4</issue><spage>334</spage><epage>336</epage><pages>334-336</pages><issn>0956-5507</issn><eissn>1365-2303</eissn><abstract>Objective
Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature.
Methods
We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman.
Results
FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3‐20 μm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A.
Conclusions
HS is a rare lesion that occurs post‐subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.
Haemoglobin spherulosis is a rare cytological finding that occurs secondary to vitreous haemorrhage. Spherical globules composed of haemoglobin A appear as smooth, rounded, slightly refractile ‘beads’ in cytocentrifugation smears.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36825891</pmid><doi>10.1111/cyt.13223</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-0531-2690</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0956-5507 |
| ispartof | Cytopathology (Oxford), 2023-07, Vol.34 (4), p.334-336 |
| issn | 0956-5507 1365-2303 |
| language | eng |
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| source | MEDLINE; Wiley-Blackwell Full Collection |
| subjects | Aged Biopsy Biopsy, Fine-Needle Cytopathology Female fine needle haemoglobin spherulosis Hemoglobin Hemoglobins Hemorrhage Humans Lesions Lymphocytes Spherules vitreous fluid |
| title | Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion |
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