Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes

Gingerols, mainly [6]-gingerol (6G), [8]-gingerol (8G), and [10]-gingerol (10G), are the functional and specific pungent phytochemicals in ginger. However, poor oral bioavailability limits their applications owing to extensive metabolism. The present study aims to characterize the cytochrome P450 (C...

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Veröffentlicht in:	RSC advances 2023-02, Vol.13 (9), p.584-5812
Hauptverfasser:	Chen, Chanjuan, Chen, Xintong, Mo, Qingmei, Liu, Jie, Yao, Xinsheng, Di, Xin, Qin, Zifei, He, Liangliang, Yao, Zhihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Bioavailability Chemistry Cytochrome Cytochromes P450 Enzymes Gingerol Liver Metabolism Metabolites Molecular chains Oxidation Substrates
Online-Zugang:	Volltext
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