Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats
Early intervention can significantly improve the colorectal cancer survival rate. Foods rich in phenolic compounds, such as jaboticaba ( Myrciaria cauliflora ), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2023-06, Vol.78 (2), p.286-291 |
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| creator | Ardanareswari, Katharina Lowisia, Webiana Soedarini, Bernadeta Liao, Jiunn-Wang Chung, Yun-Chin |
| description | Early intervention can significantly improve the colorectal cancer survival rate. Foods rich in phenolic compounds, such as jaboticaba (
Myrciaria cauliflora
), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA). This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Providence University (Trial Registration Number 20180419A01, registration date: 22 December 2018). The FEX contains gallic acid and an especially high ellagic acid concentration of 54.41 ± 1.80 and 209.79 ± 2.49 mg/100 g FEX. The highest total ACF number (150.00 ± 43.86) was recorded in the DMH control (D) group. After 56 days of oral FEX treatment, the total ACF number in the low FEX dosage (DL) group was significantly lower compared to the D group (
p
5 foci), which has a higher probability of progressing to later stage, was significantly decreased in the high FEX dosage (DH) group. The 16s rDNA metagenomic sequencing of the cecal material revealed that the CRC biomarker
Lachnoclostridium
was significantly suppressed in the DH group (
p
|
| doi_str_mv | 10.1007/s11130-023-01051-z |
| format | Article |
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Myrciaria cauliflora
), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA). This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Providence University (Trial Registration Number 20180419A01, registration date: 22 December 2018). The FEX contains gallic acid and an especially high ellagic acid concentration of 54.41 ± 1.80 and 209.79 ± 2.49 mg/100 g FEX. The highest total ACF number (150.00 ± 43.86) was recorded in the DMH control (D) group. After 56 days of oral FEX treatment, the total ACF number in the low FEX dosage (DL) group was significantly lower compared to the D group (
p
< 0.05). The large-sized ACF (> 5 foci), which has a higher probability of progressing to later stage, was significantly decreased in the high FEX dosage (DH) group. The 16s rDNA metagenomic sequencing of the cecal material revealed that the CRC biomarker
Lachnoclostridium
was significantly suppressed in the DH group (
p
< 0.05), whereas some SCFA-producing taxa and the cecal butyrate concentration were significantly elevated in the DL and DH groups (
p
< 0.05). This study demonstrated the potential of jaboticaba whole fruit in CRC prevention, especially in the initial stage, by shifting gut microbiota composition and improving cecal butyrate level.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-023-01051-z</identifier><identifier>PMID: 36820999</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1,2-Dimethylhydrazine ; Biomarkers ; butyrates ; Cancer ; carcinogenesis ; Cecum ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colorectal cancer ; Colorectal carcinoma ; colorectal neoplasms ; Composition ; Crypts ; Dimethylhydrazines ; Dosage ; Ecology ; Ellagic acid ; Fatty acids ; Food Science ; fruit extracts ; Fruits ; Gallic acid ; Institutional Animal Care and Use Committee ; Intestinal microflora ; intestinal microorganisms ; Metagenomics ; Microbiota ; Microorganisms ; Myrciaria cauliflora ; Nutrition ; Phenolic compounds ; Phenols ; Plant Physiology ; Plinia cauliflora ; probability ; rRNA 16S ; short chain fatty acids ; Survival ; survival rate ; Tumorigenesis</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2023-06, Vol.78 (2), p.286-291</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-c53f88016d6bbbddd497cf3cd69d1ef470f569968d0a97e6e3635821504e52e73</citedby><cites>FETCH-LOGICAL-c408t-c53f88016d6bbbddd497cf3cd69d1ef470f569968d0a97e6e3635821504e52e73</cites><orcidid>0000-0001-5882-9127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11130-023-01051-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11130-023-01051-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36820999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ardanareswari, Katharina</creatorcontrib><creatorcontrib>Lowisia, Webiana</creatorcontrib><creatorcontrib>Soedarini, Bernadeta</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Chung, Yun-Chin</creatorcontrib><title>Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>Early intervention can significantly improve the colorectal cancer survival rate. Foods rich in phenolic compounds, such as jaboticaba (
Myrciaria cauliflora
), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA). This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Providence University (Trial Registration Number 20180419A01, registration date: 22 December 2018). The FEX contains gallic acid and an especially high ellagic acid concentration of 54.41 ± 1.80 and 209.79 ± 2.49 mg/100 g FEX. The highest total ACF number (150.00 ± 43.86) was recorded in the DMH control (D) group. After 56 days of oral FEX treatment, the total ACF number in the low FEX dosage (DL) group was significantly lower compared to the D group (
p
< 0.05). The large-sized ACF (> 5 foci), which has a higher probability of progressing to later stage, was significantly decreased in the high FEX dosage (DH) group. The 16s rDNA metagenomic sequencing of the cecal material revealed that the CRC biomarker
Lachnoclostridium
was significantly suppressed in the DH group (
p
< 0.05), whereas some SCFA-producing taxa and the cecal butyrate concentration were significantly elevated in the DL and DH groups (
p
< 0.05). This study demonstrated the potential of jaboticaba whole fruit in CRC prevention, especially in the initial stage, by shifting gut microbiota composition and improving cecal butyrate level.</description><subject>1,2-Dimethylhydrazine</subject><subject>Biomarkers</subject><subject>butyrates</subject><subject>Cancer</subject><subject>carcinogenesis</subject><subject>Cecum</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>colorectal neoplasms</subject><subject>Composition</subject><subject>Crypts</subject><subject>Dimethylhydrazines</subject><subject>Dosage</subject><subject>Ecology</subject><subject>Ellagic acid</subject><subject>Fatty acids</subject><subject>Food Science</subject><subject>fruit extracts</subject><subject>Fruits</subject><subject>Gallic acid</subject><subject>Institutional Animal Care and Use Committee</subject><subject>Intestinal microflora</subject><subject>intestinal microorganisms</subject><subject>Metagenomics</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Myrciaria cauliflora</subject><subject>Nutrition</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Plant Physiology</subject><subject>Plinia cauliflora</subject><subject>probability</subject><subject>rRNA 16S</subject><subject>short chain fatty acids</subject><subject>Survival</subject><subject>survival rate</subject><subject>Tumorigenesis</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rFTEUhoMo9rb6B1xIwE0FoyfJTD6W5dqrlYrgxzpkkoymzFeTDHTur-_UWxVc6OoszvO-h8OD0DMKrymAfJMppRwIME6AQk3J_gHa0FpyoilUD9EGNKNEC6GO0HHOV7CGhKgfoyMuFAOt9QbdfLDNWKKzjcWnH5fkok3RYmfnLrbdmOxLvEtzLPj8piTrCv4yT1MKOQePz5qQkh0K3qZlKng3pt6WOA44Dpi-YuRt7ENZuh-LT3Yfh0AuBj-7NfjZlvwEPWptl8PT-3mCvu3Ov27fk8tP7y62Z5fEVaAKcTVvlQIqvGiaxntfaela7rzQnoa2ktDWQmuhPFgtgwhc8FoxWkMVahYkP0Gnh94pjddzyMX0MbvQdXYI45wNpzWnmsmq-i_KpNS8koreoS_-Qq_GOQ3rI4apCqSSIPhKsQPl0phzCq2ZUuxtWgwFc6fQHBSaVaH5qdDs19Dz--q56YP_HfnlbAX4Acjravge0p_b_6i9BTKYptU</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Ardanareswari, Katharina</creator><creator>Lowisia, Webiana</creator><creator>Soedarini, Bernadeta</creator><creator>Liao, Jiunn-Wang</creator><creator>Chung, Yun-Chin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-5882-9127</orcidid></search><sort><creationdate>20230601</creationdate><title>Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats</title><author>Ardanareswari, Katharina ; Lowisia, Webiana ; Soedarini, Bernadeta ; Liao, Jiunn-Wang ; Chung, Yun-Chin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-c53f88016d6bbbddd497cf3cd69d1ef470f569968d0a97e6e3635821504e52e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1,2-Dimethylhydrazine</topic><topic>Biomarkers</topic><topic>butyrates</topic><topic>Cancer</topic><topic>carcinogenesis</topic><topic>Cecum</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>colorectal neoplasms</topic><topic>Composition</topic><topic>Crypts</topic><topic>Dimethylhydrazines</topic><topic>Dosage</topic><topic>Ecology</topic><topic>Ellagic acid</topic><topic>Fatty acids</topic><topic>Food Science</topic><topic>fruit extracts</topic><topic>Fruits</topic><topic>Gallic acid</topic><topic>Institutional Animal Care and Use Committee</topic><topic>Intestinal microflora</topic><topic>intestinal microorganisms</topic><topic>Metagenomics</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Myrciaria cauliflora</topic><topic>Nutrition</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Plant Physiology</topic><topic>Plinia cauliflora</topic><topic>probability</topic><topic>rRNA 16S</topic><topic>short chain fatty acids</topic><topic>Survival</topic><topic>survival rate</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ardanareswari, Katharina</creatorcontrib><creatorcontrib>Lowisia, Webiana</creatorcontrib><creatorcontrib>Soedarini, Bernadeta</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Chung, Yun-Chin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ardanareswari, Katharina</au><au>Lowisia, Webiana</au><au>Soedarini, Bernadeta</au><au>Liao, Jiunn-Wang</au><au>Chung, Yun-Chin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>78</volume><issue>2</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>Early intervention can significantly improve the colorectal cancer survival rate. Foods rich in phenolic compounds, such as jaboticaba (
Myrciaria cauliflora
), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA). This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Providence University (Trial Registration Number 20180419A01, registration date: 22 December 2018). The FEX contains gallic acid and an especially high ellagic acid concentration of 54.41 ± 1.80 and 209.79 ± 2.49 mg/100 g FEX. The highest total ACF number (150.00 ± 43.86) was recorded in the DMH control (D) group. After 56 days of oral FEX treatment, the total ACF number in the low FEX dosage (DL) group was significantly lower compared to the D group (
p
< 0.05). The large-sized ACF (> 5 foci), which has a higher probability of progressing to later stage, was significantly decreased in the high FEX dosage (DH) group. The 16s rDNA metagenomic sequencing of the cecal material revealed that the CRC biomarker
Lachnoclostridium
was significantly suppressed in the DH group (
p
< 0.05), whereas some SCFA-producing taxa and the cecal butyrate concentration were significantly elevated in the DL and DH groups (
p
< 0.05). This study demonstrated the potential of jaboticaba whole fruit in CRC prevention, especially in the initial stage, by shifting gut microbiota composition and improving cecal butyrate level.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36820999</pmid><doi>10.1007/s11130-023-01051-z</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5882-9127</orcidid></addata></record> |
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| subjects | 1,2-Dimethylhydrazine Biomarkers butyrates Cancer carcinogenesis Cecum Chemistry Chemistry and Materials Science Chemistry/Food Science Colorectal cancer Colorectal carcinoma colorectal neoplasms Composition Crypts Dimethylhydrazines Dosage Ecology Ellagic acid Fatty acids Food Science fruit extracts Fruits Gallic acid Institutional Animal Care and Use Committee Intestinal microflora intestinal microorganisms Metagenomics Microbiota Microorganisms Myrciaria cauliflora Nutrition Phenolic compounds Phenols Plant Physiology Plinia cauliflora probability rRNA 16S short chain fatty acids Survival survival rate Tumorigenesis |
| title | Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats |
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