Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma
Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not deter...
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| creator | Xue, Ting Yan, Ru Li, Zaishang Guo, Shengjie Xiao, Xiao Jin, Jietian Jiang, Lijuan Ma, Huali Wu, Chong Liu, Tingyu Wei, Lichao Xiong, Longbin Zhou, Fangjian Yao, Kai Liu, Ranyi Han, Hui |
| description | Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC. Immunohistochemistry was carried out to evaluate the protein expression of FADD. The difference between FADD
high
and FADD
low
was explored by RNA sequencing from available cases. The immune environment evaluation of CD4, CD8, and Foxp3 was performed by immunohistochemical. In this study, we found that FADD was overexpressed in 19.6 (39/199) patients, and the overexpression of FADD was associated with phimosis (
p
=0.007), N stage (
p |
| doi_str_mv | 10.1007/s00428-023-03514-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2779340874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2808755251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-6129ac270a01a4347892558f1fc5f1336750a6672207bcac14cbde9c90c6b3383</originalsourceid><addsrcrecordid>eNp9kLtOAzEQRS0EgvD4AQpkiYZmYfxar8so4SVFggJEaTmONzLatYOdLfh7HMJDoqCaYs7cuToInRK4JADyKgNw2lRAWQVMEF6pHTQinNGKMpC7aASKi6pmRB6gw5xfAShpSL2PDljdEKYEjNDLY4rLEPPaW5z9MvjWWxOswyYssO_7IThsY0quM2uXcWzxzXg6xT7glQu-czi_DaaPQ8bWdR22JlkfYm-O0V5ruuxOvuYRer65fprcVbOH2_vJeFZZJsW6qglVxlIJBojhjMtGUSGalrRWtISxWgowdS0pBTm3xhJu5wunrAJbzxlr2BG62OauUnwbXF7r3udNFRNcaaWplIpxaCQv6Pkf9DUOKZR2mjaFEIIKUii6pWyKOSfX6lXyvUnvmoDeaNdb7bpo15_atSpHZ1_Rw7x3i5-Tb88FYFsgl1VYuvT7-5_YD2zoi8M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2808755251</pqid></control><display><type>article</type><title>Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Xue, Ting ; Yan, Ru ; Li, Zaishang ; Guo, Shengjie ; Xiao, Xiao ; Jin, Jietian ; Jiang, Lijuan ; Ma, Huali ; Wu, Chong ; Liu, Tingyu ; Wei, Lichao ; Xiong, Longbin ; Zhou, Fangjian ; Yao, Kai ; Liu, Ranyi ; Han, Hui</creator><creatorcontrib>Xue, Ting ; Yan, Ru ; Li, Zaishang ; Guo, Shengjie ; Xiao, Xiao ; Jin, Jietian ; Jiang, Lijuan ; Ma, Huali ; Wu, Chong ; Liu, Tingyu ; Wei, Lichao ; Xiong, Longbin ; Zhou, Fangjian ; Yao, Kai ; Liu, Ranyi ; Han, Hui</creatorcontrib><description>Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC. Immunohistochemistry was carried out to evaluate the protein expression of FADD. The difference between FADD
high
and FADD
low
was explored by RNA sequencing from available cases. The immune environment evaluation of CD4, CD8, and Foxp3 was performed by immunohistochemical. In this study, we found that FADD was overexpressed in 19.6 (39/199) patients, and the overexpression of FADD was associated with phimosis (
p
=0.007), N stage (
p
<0.001), clinical stage (
p
=0.001), and histologic grade (
p
=0.005). The overexpression of FADD was an independent prognostic factor for both PFS (HR 3.976, 95% CI 2.413–6.553,
p
<0.001) and OS (HR 4.134, 95% CI 2.358–7.247,
p
<0.001). In addition, overexpression of FADD was mainly linked to T cell activation and PD-L1 expression combined with PD-L1 checkpoint in cancer. Further validation demonstrated that overexpression of FADD was positively correlated with the infiltration of Foxp3 in PSCC (
p
=0.0142). It is the first time to show that overexpression of FADD is an adjunct biomarker with poor prognosis in PSCC and could also serve as a tumor immune environment regulator.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-023-03514-9</identifier><identifier>PMID: 36813950</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>B7-H1 Antigen ; Biomarkers ; Biomarkers, Tumor - genetics ; Cancer ; Carcinoma, Squamous Cell - pathology ; CD4 antigen ; CD8 antigen ; Cell activation ; Cell proliferation ; Evaluation ; FADD protein ; Fas-Associated Death Domain Protein ; Forkhead Transcription Factors ; Foxp3 protein ; Gene sequencing ; Genital cancers ; Humans ; Immunohistochemistry ; Lymphocytes ; Lymphocytes T ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Original Article ; Pathology ; PD-L1 protein ; Penile Neoplasms - pathology ; Penis ; Prognosis ; Squamous cell carcinoma</subject><ispartof>Virchows Archiv : an international journal of pathology, 2023-05, Vol.482 (5), p.869-878</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6129ac270a01a4347892558f1fc5f1336750a6672207bcac14cbde9c90c6b3383</citedby><cites>FETCH-LOGICAL-c375t-6129ac270a01a4347892558f1fc5f1336750a6672207bcac14cbde9c90c6b3383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-023-03514-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-023-03514-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36813950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Ting</creatorcontrib><creatorcontrib>Yan, Ru</creatorcontrib><creatorcontrib>Li, Zaishang</creatorcontrib><creatorcontrib>Guo, Shengjie</creatorcontrib><creatorcontrib>Xiao, Xiao</creatorcontrib><creatorcontrib>Jin, Jietian</creatorcontrib><creatorcontrib>Jiang, Lijuan</creatorcontrib><creatorcontrib>Ma, Huali</creatorcontrib><creatorcontrib>Wu, Chong</creatorcontrib><creatorcontrib>Liu, Tingyu</creatorcontrib><creatorcontrib>Wei, Lichao</creatorcontrib><creatorcontrib>Xiong, Longbin</creatorcontrib><creatorcontrib>Zhou, Fangjian</creatorcontrib><creatorcontrib>Yao, Kai</creatorcontrib><creatorcontrib>Liu, Ranyi</creatorcontrib><creatorcontrib>Han, Hui</creatorcontrib><title>Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC. Immunohistochemistry was carried out to evaluate the protein expression of FADD. The difference between FADD
high
and FADD
low
was explored by RNA sequencing from available cases. The immune environment evaluation of CD4, CD8, and Foxp3 was performed by immunohistochemical. In this study, we found that FADD was overexpressed in 19.6 (39/199) patients, and the overexpression of FADD was associated with phimosis (
p
=0.007), N stage (
p
<0.001), clinical stage (
p
=0.001), and histologic grade (
p
=0.005). The overexpression of FADD was an independent prognostic factor for both PFS (HR 3.976, 95% CI 2.413–6.553,
p
<0.001) and OS (HR 4.134, 95% CI 2.358–7.247,
p
<0.001). In addition, overexpression of FADD was mainly linked to T cell activation and PD-L1 expression combined with PD-L1 checkpoint in cancer. Further validation demonstrated that overexpression of FADD was positively correlated with the infiltration of Foxp3 in PSCC (
p
=0.0142). It is the first time to show that overexpression of FADD is an adjunct biomarker with poor prognosis in PSCC and could also serve as a tumor immune environment regulator.</description><subject>B7-H1 Antigen</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cell activation</subject><subject>Cell proliferation</subject><subject>Evaluation</subject><subject>FADD protein</subject><subject>Fas-Associated Death Domain Protein</subject><subject>Forkhead Transcription Factors</subject><subject>Foxp3 protein</subject><subject>Gene sequencing</subject><subject>Genital cancers</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Original Article</subject><subject>Pathology</subject><subject>PD-L1 protein</subject><subject>Penile Neoplasms - pathology</subject><subject>Penis</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kLtOAzEQRS0EgvD4AQpkiYZmYfxar8so4SVFggJEaTmONzLatYOdLfh7HMJDoqCaYs7cuToInRK4JADyKgNw2lRAWQVMEF6pHTQinNGKMpC7aASKi6pmRB6gw5xfAShpSL2PDljdEKYEjNDLY4rLEPPaW5z9MvjWWxOswyYssO_7IThsY0quM2uXcWzxzXg6xT7glQu-czi_DaaPQ8bWdR22JlkfYm-O0V5ruuxOvuYRer65fprcVbOH2_vJeFZZJsW6qglVxlIJBojhjMtGUSGalrRWtISxWgowdS0pBTm3xhJu5wunrAJbzxlr2BG62OauUnwbXF7r3udNFRNcaaWplIpxaCQv6Pkf9DUOKZR2mjaFEIIKUii6pWyKOSfX6lXyvUnvmoDeaNdb7bpo15_atSpHZ1_Rw7x3i5-Tb88FYFsgl1VYuvT7-5_YD2zoi8M</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Xue, Ting</creator><creator>Yan, Ru</creator><creator>Li, Zaishang</creator><creator>Guo, Shengjie</creator><creator>Xiao, Xiao</creator><creator>Jin, Jietian</creator><creator>Jiang, Lijuan</creator><creator>Ma, Huali</creator><creator>Wu, Chong</creator><creator>Liu, Tingyu</creator><creator>Wei, Lichao</creator><creator>Xiong, Longbin</creator><creator>Zhou, Fangjian</creator><creator>Yao, Kai</creator><creator>Liu, Ranyi</creator><creator>Han, Hui</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230501</creationdate><title>Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma</title><author>Xue, Ting ; Yan, Ru ; Li, Zaishang ; Guo, Shengjie ; Xiao, Xiao ; Jin, Jietian ; Jiang, Lijuan ; Ma, Huali ; Wu, Chong ; Liu, Tingyu ; Wei, Lichao ; Xiong, Longbin ; Zhou, Fangjian ; Yao, Kai ; Liu, Ranyi ; Han, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6129ac270a01a4347892558f1fc5f1336750a6672207bcac14cbde9c90c6b3383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>B7-H1 Antigen</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Cell activation</topic><topic>Cell proliferation</topic><topic>Evaluation</topic><topic>FADD protein</topic><topic>Fas-Associated Death Domain Protein</topic><topic>Forkhead Transcription Factors</topic><topic>Foxp3 protein</topic><topic>Gene sequencing</topic><topic>Genital cancers</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Original Article</topic><topic>Pathology</topic><topic>PD-L1 protein</topic><topic>Penile Neoplasms - pathology</topic><topic>Penis</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Ting</creatorcontrib><creatorcontrib>Yan, Ru</creatorcontrib><creatorcontrib>Li, Zaishang</creatorcontrib><creatorcontrib>Guo, Shengjie</creatorcontrib><creatorcontrib>Xiao, Xiao</creatorcontrib><creatorcontrib>Jin, Jietian</creatorcontrib><creatorcontrib>Jiang, Lijuan</creatorcontrib><creatorcontrib>Ma, Huali</creatorcontrib><creatorcontrib>Wu, Chong</creatorcontrib><creatorcontrib>Liu, Tingyu</creatorcontrib><creatorcontrib>Wei, Lichao</creatorcontrib><creatorcontrib>Xiong, Longbin</creatorcontrib><creatorcontrib>Zhou, Fangjian</creatorcontrib><creatorcontrib>Yao, Kai</creatorcontrib><creatorcontrib>Liu, Ranyi</creatorcontrib><creatorcontrib>Han, Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Ting</au><au>Yan, Ru</au><au>Li, Zaishang</au><au>Guo, Shengjie</au><au>Xiao, Xiao</au><au>Jin, Jietian</au><au>Jiang, Lijuan</au><au>Ma, Huali</au><au>Wu, Chong</au><au>Liu, Tingyu</au><au>Wei, Lichao</au><au>Xiong, Longbin</au><au>Zhou, Fangjian</au><au>Yao, Kai</au><au>Liu, Ranyi</au><au>Han, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>482</volume><issue>5</issue><spage>869</spage><epage>878</epage><pages>869-878</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC. Immunohistochemistry was carried out to evaluate the protein expression of FADD. The difference between FADD
high
and FADD
low
was explored by RNA sequencing from available cases. The immune environment evaluation of CD4, CD8, and Foxp3 was performed by immunohistochemical. In this study, we found that FADD was overexpressed in 19.6 (39/199) patients, and the overexpression of FADD was associated with phimosis (
p
=0.007), N stage (
p
<0.001), clinical stage (
p
=0.001), and histologic grade (
p
=0.005). The overexpression of FADD was an independent prognostic factor for both PFS (HR 3.976, 95% CI 2.413–6.553,
p
<0.001) and OS (HR 4.134, 95% CI 2.358–7.247,
p
<0.001). In addition, overexpression of FADD was mainly linked to T cell activation and PD-L1 expression combined with PD-L1 checkpoint in cancer. Further validation demonstrated that overexpression of FADD was positively correlated with the infiltration of Foxp3 in PSCC (
p
=0.0142). It is the first time to show that overexpression of FADD is an adjunct biomarker with poor prognosis in PSCC and could also serve as a tumor immune environment regulator.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36813950</pmid><doi>10.1007/s00428-023-03514-9</doi><tpages>10</tpages></addata></record> |
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| subjects | B7-H1 Antigen Biomarkers Biomarkers, Tumor - genetics Cancer Carcinoma, Squamous Cell - pathology CD4 antigen CD8 antigen Cell activation Cell proliferation Evaluation FADD protein Fas-Associated Death Domain Protein Forkhead Transcription Factors Foxp3 protein Gene sequencing Genital cancers Humans Immunohistochemistry Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Metastases Original Article Pathology PD-L1 protein Penile Neoplasms - pathology Penis Prognosis Squamous cell carcinoma |
| title | Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma |
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