Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review

The decision to pursue one's desire for children is a basic human right. For transgender and gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's desire for children due to the impact of this treatment on their reproductive organs. We systematical...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Best practice & research. Clinical obstetrics & gynaecology 2023-03, Vol.87, p.102312-102312, Article 102312
Hauptverfasser: Stolk, T.H.R., Asseler, J.D., Huirne, J.A.F., van den Boogaard, E., van Mello, N.M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 102312
container_issue
container_start_page 102312
container_title Best practice & research. Clinical obstetrics & gynaecology
container_volume 87
creator Stolk, T.H.R.
Asseler, J.D.
Huirne, J.A.F.
van den Boogaard, E.
van Mello, N.M.
description The decision to pursue one's desire for children is a basic human right. For transgender and gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's desire for children due to the impact of this treatment on their reproductive organs. We systematically included 76 studies of varying quality describing the desire for children and parenthood; fertility counseling and utilization; and fertility preservation options and outcomes in TGD people. The majority of TGD people expressed a desire for children. Fertility preservation utilization rates were low as there are many barriers to pursue fertility preservation. The most utilized fertility preservation strategies include oocyte vitrification and sperm banking through masturbation. Oocyte vitrification showed successful outcomes, even after testosterone cessation. Sperm analyses when banking sperm showed a lower quality compared to cis male samples even prior to gender-affirming hormone treatment and an uncertain recovery of spermatogenesis after discontinuing treatment. •Transgender and gender diverse (TGD) people may have a (future) desire for children, biologically or otherwise.•All TGD people should receive fertility counseling prior to puberty suppression and gender affirming treatment.•Oocyte vitrification outcomes in TGD people are comparable to cis population, even with prior testosterone use.•Semen preservation before gender affirming hormone treatment is strongly recommended.•TGD people’s journey to parenthood is related to their mental reproductive capacity, sexual attraction and gametes.
doi_str_mv 10.1016/j.bpobgyn.2023.102312
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2778979826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1521693423000019</els_id><sourcerecordid>2778979826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-f44e47ae5fef709547f8f7939da02f8447e7e6c33d4d03f45d0c5926be17d1453</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EgvL4BJCXbFL8ShyzQVV5SkhsYG2l9hhcpU6w06L8PSkpbFnNaHTujOYgdE7JlBJaXC2ni7ZZvPdhygjjw4xxyvbQhOacZVRxtr_tGc0KxcUROk5pSQjniuWH6IgXJSmE4BNU30LyEbBrIjYfvrYRAq6CxQ5i52vf9biNkCBuqs43AfuAu1iF9A7BQvwhxzazfgMxAW6haWu4xjOc-tTBasgZHGHj4esUHbiqTnC2qyfo7f7udf6YPb88PM1nz5kRlHWZEwKErCB34CRRuZCudFJxZSvCXCmEBAmF4dwKS7gTuSUmV6xYAJWWipyfoMtxbxubzzWkTq98MlDXVYBmnTSTslRSlawY0HxETWxSiuB0G_2qir2mRG9F66XeidZb0XoUPeQudifWixXYv9Sv2QG4GQEYHh2ejzoZD8GAHXSbTtvG_3PiG7jFkxc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2778979826</pqid></control><display><type>article</type><title>Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Stolk, T.H.R. ; Asseler, J.D. ; Huirne, J.A.F. ; van den Boogaard, E. ; van Mello, N.M.</creator><creatorcontrib>Stolk, T.H.R. ; Asseler, J.D. ; Huirne, J.A.F. ; van den Boogaard, E. ; van Mello, N.M.</creatorcontrib><description>The decision to pursue one's desire for children is a basic human right. For transgender and gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's desire for children due to the impact of this treatment on their reproductive organs. We systematically included 76 studies of varying quality describing the desire for children and parenthood; fertility counseling and utilization; and fertility preservation options and outcomes in TGD people. The majority of TGD people expressed a desire for children. Fertility preservation utilization rates were low as there are many barriers to pursue fertility preservation. The most utilized fertility preservation strategies include oocyte vitrification and sperm banking through masturbation. Oocyte vitrification showed successful outcomes, even after testosterone cessation. Sperm analyses when banking sperm showed a lower quality compared to cis male samples even prior to gender-affirming hormone treatment and an uncertain recovery of spermatogenesis after discontinuing treatment. •Transgender and gender diverse (TGD) people may have a (future) desire for children, biologically or otherwise.•All TGD people should receive fertility counseling prior to puberty suppression and gender affirming treatment.•Oocyte vitrification outcomes in TGD people are comparable to cis population, even with prior testosterone use.•Semen preservation before gender affirming hormone treatment is strongly recommended.•TGD people’s journey to parenthood is related to their mental reproductive capacity, sexual attraction and gametes.</description><identifier>ISSN: 1521-6934</identifier><identifier>EISSN: 1532-1932</identifier><identifier>DOI: 10.1016/j.bpobgyn.2023.102312</identifier><identifier>PMID: 36806443</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Female ; Fertility ; Fertility Preservation ; Gender dysphoria ; Humans ; Male ; Parenthood ; Semen ; Systematic review ; Transgender Persons</subject><ispartof>Best practice &amp; research. Clinical obstetrics &amp; gynaecology, 2023-03, Vol.87, p.102312-102312, Article 102312</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-f44e47ae5fef709547f8f7939da02f8447e7e6c33d4d03f45d0c5926be17d1453</citedby><cites>FETCH-LOGICAL-c412t-f44e47ae5fef709547f8f7939da02f8447e7e6c33d4d03f45d0c5926be17d1453</cites><orcidid>0000-0003-4161-7405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bpobgyn.2023.102312$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36806443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stolk, T.H.R.</creatorcontrib><creatorcontrib>Asseler, J.D.</creatorcontrib><creatorcontrib>Huirne, J.A.F.</creatorcontrib><creatorcontrib>van den Boogaard, E.</creatorcontrib><creatorcontrib>van Mello, N.M.</creatorcontrib><title>Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review</title><title>Best practice &amp; research. Clinical obstetrics &amp; gynaecology</title><addtitle>Best Pract Res Clin Obstet Gynaecol</addtitle><description>The decision to pursue one's desire for children is a basic human right. For transgender and gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's desire for children due to the impact of this treatment on their reproductive organs. We systematically included 76 studies of varying quality describing the desire for children and parenthood; fertility counseling and utilization; and fertility preservation options and outcomes in TGD people. The majority of TGD people expressed a desire for children. Fertility preservation utilization rates were low as there are many barriers to pursue fertility preservation. The most utilized fertility preservation strategies include oocyte vitrification and sperm banking through masturbation. Oocyte vitrification showed successful outcomes, even after testosterone cessation. Sperm analyses when banking sperm showed a lower quality compared to cis male samples even prior to gender-affirming hormone treatment and an uncertain recovery of spermatogenesis after discontinuing treatment. •Transgender and gender diverse (TGD) people may have a (future) desire for children, biologically or otherwise.•All TGD people should receive fertility counseling prior to puberty suppression and gender affirming treatment.•Oocyte vitrification outcomes in TGD people are comparable to cis population, even with prior testosterone use.•Semen preservation before gender affirming hormone treatment is strongly recommended.•TGD people’s journey to parenthood is related to their mental reproductive capacity, sexual attraction and gametes.</description><subject>Female</subject><subject>Fertility</subject><subject>Fertility Preservation</subject><subject>Gender dysphoria</subject><subject>Humans</subject><subject>Male</subject><subject>Parenthood</subject><subject>Semen</subject><subject>Systematic review</subject><subject>Transgender Persons</subject><issn>1521-6934</issn><issn>1532-1932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BJCXbFL8ShyzQVV5SkhsYG2l9hhcpU6w06L8PSkpbFnNaHTujOYgdE7JlBJaXC2ni7ZZvPdhygjjw4xxyvbQhOacZVRxtr_tGc0KxcUROk5pSQjniuWH6IgXJSmE4BNU30LyEbBrIjYfvrYRAq6CxQ5i52vf9biNkCBuqs43AfuAu1iF9A7BQvwhxzazfgMxAW6haWu4xjOc-tTBasgZHGHj4esUHbiqTnC2qyfo7f7udf6YPb88PM1nz5kRlHWZEwKErCB34CRRuZCudFJxZSvCXCmEBAmF4dwKS7gTuSUmV6xYAJWWipyfoMtxbxubzzWkTq98MlDXVYBmnTSTslRSlawY0HxETWxSiuB0G_2qir2mRG9F66XeidZb0XoUPeQudifWixXYv9Sv2QG4GQEYHh2ejzoZD8GAHXSbTtvG_3PiG7jFkxc</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Stolk, T.H.R.</creator><creator>Asseler, J.D.</creator><creator>Huirne, J.A.F.</creator><creator>van den Boogaard, E.</creator><creator>van Mello, N.M.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4161-7405</orcidid></search><sort><creationdate>202303</creationdate><title>Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review</title><author>Stolk, T.H.R. ; Asseler, J.D. ; Huirne, J.A.F. ; van den Boogaard, E. ; van Mello, N.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-f44e47ae5fef709547f8f7939da02f8447e7e6c33d4d03f45d0c5926be17d1453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Female</topic><topic>Fertility</topic><topic>Fertility Preservation</topic><topic>Gender dysphoria</topic><topic>Humans</topic><topic>Male</topic><topic>Parenthood</topic><topic>Semen</topic><topic>Systematic review</topic><topic>Transgender Persons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stolk, T.H.R.</creatorcontrib><creatorcontrib>Asseler, J.D.</creatorcontrib><creatorcontrib>Huirne, J.A.F.</creatorcontrib><creatorcontrib>van den Boogaard, E.</creatorcontrib><creatorcontrib>van Mello, N.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Best practice &amp; research. Clinical obstetrics &amp; gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stolk, T.H.R.</au><au>Asseler, J.D.</au><au>Huirne, J.A.F.</au><au>van den Boogaard, E.</au><au>van Mello, N.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review</atitle><jtitle>Best practice &amp; research. Clinical obstetrics &amp; gynaecology</jtitle><addtitle>Best Pract Res Clin Obstet Gynaecol</addtitle><date>2023-03</date><risdate>2023</risdate><volume>87</volume><spage>102312</spage><epage>102312</epage><pages>102312-102312</pages><artnum>102312</artnum><issn>1521-6934</issn><eissn>1532-1932</eissn><abstract>The decision to pursue one's desire for children is a basic human right. For transgender and gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's desire for children due to the impact of this treatment on their reproductive organs. We systematically included 76 studies of varying quality describing the desire for children and parenthood; fertility counseling and utilization; and fertility preservation options and outcomes in TGD people. The majority of TGD people expressed a desire for children. Fertility preservation utilization rates were low as there are many barriers to pursue fertility preservation. The most utilized fertility preservation strategies include oocyte vitrification and sperm banking through masturbation. Oocyte vitrification showed successful outcomes, even after testosterone cessation. Sperm analyses when banking sperm showed a lower quality compared to cis male samples even prior to gender-affirming hormone treatment and an uncertain recovery of spermatogenesis after discontinuing treatment. •Transgender and gender diverse (TGD) people may have a (future) desire for children, biologically or otherwise.•All TGD people should receive fertility counseling prior to puberty suppression and gender affirming treatment.•Oocyte vitrification outcomes in TGD people are comparable to cis population, even with prior testosterone use.•Semen preservation before gender affirming hormone treatment is strongly recommended.•TGD people’s journey to parenthood is related to their mental reproductive capacity, sexual attraction and gametes.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>36806443</pmid><doi>10.1016/j.bpobgyn.2023.102312</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4161-7405</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1521-6934
ispartof Best practice & research. Clinical obstetrics & gynaecology, 2023-03, Vol.87, p.102312-102312, Article 102312
issn 1521-6934
1532-1932
language eng
recordid cdi_proquest_miscellaneous_2778979826
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Female
Fertility
Fertility Preservation
Gender dysphoria
Humans
Male
Parenthood
Semen
Systematic review
Transgender Persons
title Desire for children and fertility preservation in transgender and gender-diverse people: A systematic review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-09T12%3A00%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Desire%20for%20children%20and%20fertility%20preservation%20in%20transgender%20and%20gender-diverse%20people:%20A%20systematic%20review&rft.jtitle=Best%20practice%20&%20research.%20Clinical%20obstetrics%20&%20gynaecology&rft.au=Stolk,%20T.H.R.&rft.date=2023-03&rft.volume=87&rft.spage=102312&rft.epage=102312&rft.pages=102312-102312&rft.artnum=102312&rft.issn=1521-6934&rft.eissn=1532-1932&rft_id=info:doi/10.1016/j.bpobgyn.2023.102312&rft_dat=%3Cproquest_cross%3E2778979826%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2778979826&rft_id=info:pmid/36806443&rft_els_id=S1521693423000019&rfr_iscdi=true