The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus
Large evidence has shown that cholestasis has a wide-range of deleterious effects on brain function, and also, on neurocognitive functions including learning and memory. On the other hand, crocin (derived from Crocus sativus ) is a medicinal natural compound that induces neuroprotective and precogni...
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| Veröffentlicht in: | Metabolic brain disease 2023-04, Vol.38 (4), p.1167-1176 |
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| creator | Mehrabanifar, Saba Hesami-Tackallou, Saeed Vaseghi, Salar Nasehi, Mohammad |
| description | Large evidence has shown that cholestasis has a wide-range of deleterious effects on brain function, and also, on neurocognitive functions including learning and memory. On the other hand, crocin (derived from
Crocus sativus
) is a medicinal natural compound that induces neuroprotective and precognitive effects. In this study, we aimed to evaluate the effect of crocin on spatial learning and memory in cholestatic rats with respect to the level of mitochondrial transcriptional factor A (TFAM), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), catalase (CAT), and superoxide dismutase (SOD) in the hippocampus of male Wistar rats. Bile duct ligation (BDL) was used to induce cholestasis. Y-maze apparatus was used to assess spatial memory performance and real-time PCR was used to assess TFAM and PGC-1α gene expression. Also, crocin was injected intraperitoneal at the doses of 15, 20, and 30 mg/kg for thirty days. The results showed that BDL impaired spatial memory in rats. BDL also decreased SOD, TFAM, and PGC-1α level. In addition, crocin partially reversed the impairment effect of BDL on spatial memory. Crocin (30 mg/kg) also reversed the effect of BDL on SOD, TFAM, and PGC-1α. Of note, the effect of BDL on CAT activity was controversial. It seems that BDL can increase CAT activity. In addition, crocin (30 mg/kg) reversed the enhancement of CAT following BDL to its control level. In conclusion, crocin may induce a significant neuroprotective effect on cholestasis-induced memory impairment. |
| doi_str_mv | 10.1007/s11011-023-01176-9 |
| format | Article |
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Crocus sativus
) is a medicinal natural compound that induces neuroprotective and precognitive effects. In this study, we aimed to evaluate the effect of crocin on spatial learning and memory in cholestatic rats with respect to the level of mitochondrial transcriptional factor A (TFAM), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), catalase (CAT), and superoxide dismutase (SOD) in the hippocampus of male Wistar rats. Bile duct ligation (BDL) was used to induce cholestasis. Y-maze apparatus was used to assess spatial memory performance and real-time PCR was used to assess TFAM and PGC-1α gene expression. Also, crocin was injected intraperitoneal at the doses of 15, 20, and 30 mg/kg for thirty days. The results showed that BDL impaired spatial memory in rats. BDL also decreased SOD, TFAM, and PGC-1α level. In addition, crocin partially reversed the impairment effect of BDL on spatial memory. Crocin (30 mg/kg) also reversed the effect of BDL on SOD, TFAM, and PGC-1α. Of note, the effect of BDL on CAT activity was controversial. It seems that BDL can increase CAT activity. In addition, crocin (30 mg/kg) reversed the enhancement of CAT following BDL to its control level. In conclusion, crocin may induce a significant neuroprotective effect on cholestasis-induced memory impairment.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-023-01176-9</identifier><identifier>PMID: 36807082</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal memory ; Animals ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Bile ducts ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Catalase ; Catalase - metabolism ; Cholestasis ; Cholestasis - complications ; Cholestasis - drug therapy ; Cognition ; Cognitive ability ; Gallbladder diseases ; Gene expression ; Hippocampus ; Hippocampus - metabolism ; Impairment ; Learning ; Male ; Memory ; Memory Disorders - drug therapy ; Memory Disorders - etiology ; Memory Disorders - metabolism ; Memory tasks ; Metabolic Diseases ; Mitochondria ; Neurology ; Neuroprotection ; Neurosciences ; Oncology ; Original Article ; Oxidative stress ; Peroxisome proliferator-activated receptors ; Rats ; Rats, Wistar ; Saffron ; Spatial analysis ; Spatial discrimination learning ; Spatial Memory ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Transcription Factors - metabolism</subject><ispartof>Metabolic brain disease, 2023-04, Vol.38 (4), p.1167-1176</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-62a1e55dfbc530fe433d9b7927fcc6f59d43cf85cc23316b7ba5dc0ee65c270e3</citedby><cites>FETCH-LOGICAL-c375t-62a1e55dfbc530fe433d9b7927fcc6f59d43cf85cc23316b7ba5dc0ee65c270e3</cites><orcidid>0000-0002-1981-3592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-023-01176-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-023-01176-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36807082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehrabanifar, Saba</creatorcontrib><creatorcontrib>Hesami-Tackallou, Saeed</creatorcontrib><creatorcontrib>Vaseghi, Salar</creatorcontrib><creatorcontrib>Nasehi, Mohammad</creatorcontrib><title>The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Large evidence has shown that cholestasis has a wide-range of deleterious effects on brain function, and also, on neurocognitive functions including learning and memory. On the other hand, crocin (derived from
Crocus sativus
) is a medicinal natural compound that induces neuroprotective and precognitive effects. In this study, we aimed to evaluate the effect of crocin on spatial learning and memory in cholestatic rats with respect to the level of mitochondrial transcriptional factor A (TFAM), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), catalase (CAT), and superoxide dismutase (SOD) in the hippocampus of male Wistar rats. Bile duct ligation (BDL) was used to induce cholestasis. Y-maze apparatus was used to assess spatial memory performance and real-time PCR was used to assess TFAM and PGC-1α gene expression. Also, crocin was injected intraperitoneal at the doses of 15, 20, and 30 mg/kg for thirty days. The results showed that BDL impaired spatial memory in rats. BDL also decreased SOD, TFAM, and PGC-1α level. In addition, crocin partially reversed the impairment effect of BDL on spatial memory. Crocin (30 mg/kg) also reversed the effect of BDL on SOD, TFAM, and PGC-1α. Of note, the effect of BDL on CAT activity was controversial. It seems that BDL can increase CAT activity. In addition, crocin (30 mg/kg) reversed the enhancement of CAT following BDL to its control level. In conclusion, crocin may induce a significant neuroprotective effect on cholestasis-induced memory impairment.</description><subject>Animal memory</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Bile ducts</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>Cholestasis</subject><subject>Cholestasis - complications</subject><subject>Cholestasis - drug therapy</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Gallbladder diseases</subject><subject>Gene expression</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Impairment</subject><subject>Learning</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - metabolism</subject><subject>Memory tasks</subject><subject>Metabolic Diseases</subject><subject>Mitochondria</subject><subject>Neurology</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Saffron</subject><subject>Spatial analysis</subject><subject>Spatial discrimination learning</subject><subject>Spatial Memory</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Transcription Factors - metabolism</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc2OFCEUhYnROO3oC7gwJG7clPLTFFXLSccZTcbool0TGi42k6oCgRqnH8tncO8zSXWPmrhwdQn38HFyDkLPKXlNCZFvMqWE0oYw3tQp26Z_gFZUSN5I3oqHaEW6TjRy3ZMz9CTnG0IIF7R_jM542xFJOrZCP7Z7wOAcmIKDwyYF4yccJmz2YYBcdPa58ZOdDVicoy5eD3iEMaQD9mPUPo0wFfzNlz1OkOPCKQGXhXoX6032FTbALQwLf3t58QHryeJPV5uG_vx-PGtT_K0vh6MBXfSgMxwXeY6Qwp23gK3P41yWRbW30Pc-xmD0GOf8FD1yesjw7H6eo8-Xb7ebd831x6v3m4vrxnApStMyTUEI63ZGcOJgzbntd7Jn0hnTOtHbNTeuE8Ywzmm7kzstrCEArTBMEuDn6NWJG1P4Otdw1OizgWHQE4Q5KyZl18u-RlylL_-R3oQ5TdWdYh1htOtoK6qKnVQ19pwTOBWTH3U6KErUUrE6VaxqxepYsVrQL-7R824E--fJ706rgJ8Eua6mL5D-_v0f7C_ywbXv</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Mehrabanifar, Saba</creator><creator>Hesami-Tackallou, Saeed</creator><creator>Vaseghi, Salar</creator><creator>Nasehi, Mohammad</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1981-3592</orcidid></search><sort><creationdate>20230401</creationdate><title>The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus</title><author>Mehrabanifar, Saba ; Hesami-Tackallou, Saeed ; Vaseghi, Salar ; Nasehi, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-62a1e55dfbc530fe433d9b7927fcc6f59d43cf85cc23316b7ba5dc0ee65c270e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal memory</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Bile ducts</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>Cholestasis</topic><topic>Cholestasis - complications</topic><topic>Cholestasis - drug therapy</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Gallbladder diseases</topic><topic>Gene expression</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Impairment</topic><topic>Learning</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - drug therapy</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - metabolism</topic><topic>Memory tasks</topic><topic>Metabolic Diseases</topic><topic>Mitochondria</topic><topic>Neurology</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Saffron</topic><topic>Spatial analysis</topic><topic>Spatial discrimination learning</topic><topic>Spatial Memory</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehrabanifar, Saba</creatorcontrib><creatorcontrib>Hesami-Tackallou, Saeed</creatorcontrib><creatorcontrib>Vaseghi, Salar</creatorcontrib><creatorcontrib>Nasehi, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehrabanifar, Saba</au><au>Hesami-Tackallou, Saeed</au><au>Vaseghi, Salar</au><au>Nasehi, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>38</volume><issue>4</issue><spage>1167</spage><epage>1176</epage><pages>1167-1176</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Large evidence has shown that cholestasis has a wide-range of deleterious effects on brain function, and also, on neurocognitive functions including learning and memory. On the other hand, crocin (derived from
Crocus sativus
) is a medicinal natural compound that induces neuroprotective and precognitive effects. In this study, we aimed to evaluate the effect of crocin on spatial learning and memory in cholestatic rats with respect to the level of mitochondrial transcriptional factor A (TFAM), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), catalase (CAT), and superoxide dismutase (SOD) in the hippocampus of male Wistar rats. Bile duct ligation (BDL) was used to induce cholestasis. Y-maze apparatus was used to assess spatial memory performance and real-time PCR was used to assess TFAM and PGC-1α gene expression. Also, crocin was injected intraperitoneal at the doses of 15, 20, and 30 mg/kg for thirty days. The results showed that BDL impaired spatial memory in rats. BDL also decreased SOD, TFAM, and PGC-1α level. In addition, crocin partially reversed the impairment effect of BDL on spatial memory. Crocin (30 mg/kg) also reversed the effect of BDL on SOD, TFAM, and PGC-1α. Of note, the effect of BDL on CAT activity was controversial. It seems that BDL can increase CAT activity. In addition, crocin (30 mg/kg) reversed the enhancement of CAT following BDL to its control level. In conclusion, crocin may induce a significant neuroprotective effect on cholestasis-induced memory impairment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36807082</pmid><doi>10.1007/s11011-023-01176-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1981-3592</orcidid></addata></record> |
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| subjects | Animal memory Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Bile ducts Biochemistry Biomedical and Life Sciences Biomedicine Catalase Catalase - metabolism Cholestasis Cholestasis - complications Cholestasis - drug therapy Cognition Cognitive ability Gallbladder diseases Gene expression Hippocampus Hippocampus - metabolism Impairment Learning Male Memory Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - metabolism Memory tasks Metabolic Diseases Mitochondria Neurology Neuroprotection Neurosciences Oncology Original Article Oxidative stress Peroxisome proliferator-activated receptors Rats Rats, Wistar Saffron Spatial analysis Spatial discrimination learning Spatial Memory Superoxide dismutase Superoxide Dismutase - metabolism Transcription Factors - metabolism |
| title | The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus |
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