Role of galectin-3 in vascular calcification
Vascular calcification is an abnormal process in which bone specific hydroxyapatite crystals are actively deposited on the vascular wall mediated by phenotypic differentiated smooth muscle cells and other mesenchymal cells under various pathological conditions. It is one of the important characteris...
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| Veröffentlicht in: | Glycoconjugate journal 2023-04, Vol.40 (2), p.149-158 |
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| creator | Cai, Yaoyao Sun, Zhen Shao, Chen Wang, Zhongqun Li, Lihua |
| description | Vascular calcification is an abnormal process in which bone specific hydroxyapatite crystals are actively deposited on the vascular wall mediated by phenotypic differentiated smooth muscle cells and other mesenchymal cells under various pathological conditions. It is one of the important characteristics in the occurrence and development of atherosclerosis, prevalent in patients with type 2 diabetes and advanced chronic kidney disease, especially those requiring maintenance hemodialysis, with severely threatening human health. Previous studies have shown that the early diagnosis and control of vascular calcification is of great significance for cardiovascular risk stratification, prevention of acute cardiovascular events, which can greatly improve the prognosis and quality of life of patients. Galectins are a family of lectin superfamily. It is widely distributed in various animals and plays an important role in many physiological and pathological processes, such as cell adhesion, apoptosis, inflammatory response, tumor metastasis and so on. Many biomarker-and association-related studies and Preclinical-mechanistic studies have suggested that galactose-specific lectin-3 (galectin-3) plays an important role in vascular calcification and vascular intimal calcification (VIC) calcification induced by Wnt/βcatenin signaling pathway, NF-κB signaling pathway and ERK1/2 signaling pathway. This paper mainly expounds the role and mechanism of galectin-3 in vascular calcification under different pathological conditions including atherosclerosis, diabetes and chronic kidney disease. |
| doi_str_mv | 10.1007/s10719-023-10106-x |
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It is one of the important characteristics in the occurrence and development of atherosclerosis, prevalent in patients with type 2 diabetes and advanced chronic kidney disease, especially those requiring maintenance hemodialysis, with severely threatening human health. Previous studies have shown that the early diagnosis and control of vascular calcification is of great significance for cardiovascular risk stratification, prevention of acute cardiovascular events, which can greatly improve the prognosis and quality of life of patients. Galectins are a family of lectin superfamily. It is widely distributed in various animals and plays an important role in many physiological and pathological processes, such as cell adhesion, apoptosis, inflammatory response, tumor metastasis and so on. Many biomarker-and association-related studies and Preclinical-mechanistic studies have suggested that galactose-specific lectin-3 (galectin-3) plays an important role in vascular calcification and vascular intimal calcification (VIC) calcification induced by Wnt/βcatenin signaling pathway, NF-κB signaling pathway and ERK1/2 signaling pathway. This paper mainly expounds the role and mechanism of galectin-3 in vascular calcification under different pathological conditions including atherosclerosis, diabetes and chronic kidney disease.</description><identifier>ISSN: 0282-0080</identifier><identifier>EISSN: 1573-4986</identifier><identifier>DOI: 10.1007/s10719-023-10106-x</identifier><identifier>PMID: 36807052</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Apoptosis ; Arteriosclerosis ; Atherosclerosis ; Biochemistry ; Biomedical and Life Sciences ; Calcification ; Calcification (ectopic) ; Cardiovascular diseases ; Cell adhesion ; Cell differentiation ; Cells, Cultured ; Crystals ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 ; Extracellular signal-regulated kinase ; Galactose ; Galectin 3 - adverse effects ; Galectin 3 - genetics ; Galectin 3 - metabolism ; Galectin-3 ; Galectins - genetics ; Hemodialysis ; Humans ; Hydroxyapatite ; Inflammation ; Kidney diseases ; Life Sciences ; Mesenchyme ; Metastases ; Mini Review ; NF-κB protein ; Pathology ; Quality of Life ; Renal Insufficiency, Chronic ; Signal transduction ; Smooth muscle ; Vascular Calcification - metabolism ; Vascular Calcification - pathology ; Vascular Calcification - prevention & control ; Wnt protein</subject><ispartof>Glycoconjugate journal, 2023-04, Vol.40 (2), p.149-158</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. 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It is one of the important characteristics in the occurrence and development of atherosclerosis, prevalent in patients with type 2 diabetes and advanced chronic kidney disease, especially those requiring maintenance hemodialysis, with severely threatening human health. Previous studies have shown that the early diagnosis and control of vascular calcification is of great significance for cardiovascular risk stratification, prevention of acute cardiovascular events, which can greatly improve the prognosis and quality of life of patients. Galectins are a family of lectin superfamily. It is widely distributed in various animals and plays an important role in many physiological and pathological processes, such as cell adhesion, apoptosis, inflammatory response, tumor metastasis and so on. Many biomarker-and association-related studies and Preclinical-mechanistic studies have suggested that galactose-specific lectin-3 (galectin-3) plays an important role in vascular calcification and vascular intimal calcification (VIC) calcification induced by Wnt/βcatenin signaling pathway, NF-κB signaling pathway and ERK1/2 signaling pathway. This paper mainly expounds the role and mechanism of galectin-3 in vascular calcification under different pathological conditions including atherosclerosis, diabetes and chronic kidney disease.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular diseases</subject><subject>Cell adhesion</subject><subject>Cell differentiation</subject><subject>Cells, Cultured</subject><subject>Crystals</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Extracellular signal-regulated kinase</subject><subject>Galactose</subject><subject>Galectin 3 - adverse effects</subject><subject>Galectin 3 - genetics</subject><subject>Galectin 3 - metabolism</subject><subject>Galectin-3</subject><subject>Galectins - genetics</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Inflammation</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Mini Review</subject><subject>NF-κB protein</subject><subject>Pathology</subject><subject>Quality of Life</subject><subject>Renal Insufficiency, Chronic</subject><subject>Signal transduction</subject><subject>Smooth muscle</subject><subject>Vascular Calcification - metabolism</subject><subject>Vascular Calcification - pathology</subject><subject>Vascular Calcification - prevention & control</subject><subject>Wnt protein</subject><issn>0282-0080</issn><issn>1573-4986</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYsHo5OkaZKjLH6BIIieQ5omS5duuyatrP_eaFcFD57mMM_7zvAgdEzgggCIy0hAEIWBMkyAQIE3O2hKuGA4V7LYRVOgkmIACRN0EOMSUiinch9NWCFBAKdTdP7UNS7rfLYwjbN93WKW1W32ZqIdGhMyaxpb-9qavu7aQ7TnTRPd0XbO0MvN9fP8Dj883t7Prx6wZYL32BFiVGW4JJX3NLfSSq4o9emop7TkRvISqkJZXpIqZ4IaW1FXSWk8qYSibIbOxt516F4HF3u9qqN1TWNa1w1RUyGkEooxktDTP-iyG0KbvkuUlFzkImeJoiNlQxdjcF6vQ70y4V0T0J8u9ehSJ5f6y6XepNDJtnooV676iXzLSwAbgZhW7cKF39v_1H4A4Yd9Zw</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Cai, Yaoyao</creator><creator>Sun, Zhen</creator><creator>Shao, Chen</creator><creator>Wang, Zhongqun</creator><creator>Li, Lihua</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230401</creationdate><title>Role of galectin-3 in vascular calcification</title><author>Cai, Yaoyao ; Sun, Zhen ; Shao, Chen ; Wang, Zhongqun ; Li, Lihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e11a9da581dff24c8c85922f680f22b5a85b0d69c5b1d4372acd2ed88af1d7923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiovascular diseases</topic><topic>Cell adhesion</topic><topic>Cell differentiation</topic><topic>Cells, Cultured</topic><topic>Crystals</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Extracellular signal-regulated kinase</topic><topic>Galactose</topic><topic>Galectin 3 - adverse effects</topic><topic>Galectin 3 - genetics</topic><topic>Galectin 3 - metabolism</topic><topic>Galectin-3</topic><topic>Galectins - genetics</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Inflammation</topic><topic>Kidney diseases</topic><topic>Life Sciences</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>Mini Review</topic><topic>NF-κB protein</topic><topic>Pathology</topic><topic>Quality of Life</topic><topic>Renal Insufficiency, Chronic</topic><topic>Signal transduction</topic><topic>Smooth muscle</topic><topic>Vascular Calcification - metabolism</topic><topic>Vascular Calcification - pathology</topic><topic>Vascular Calcification - prevention & control</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yaoyao</creatorcontrib><creatorcontrib>Sun, Zhen</creatorcontrib><creatorcontrib>Shao, Chen</creatorcontrib><creatorcontrib>Wang, Zhongqun</creatorcontrib><creatorcontrib>Li, Lihua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Glycoconjugate journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yaoyao</au><au>Sun, Zhen</au><au>Shao, Chen</au><au>Wang, Zhongqun</au><au>Li, Lihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of galectin-3 in vascular calcification</atitle><jtitle>Glycoconjugate journal</jtitle><stitle>Glycoconj J</stitle><addtitle>Glycoconj J</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>40</volume><issue>2</issue><spage>149</spage><epage>158</epage><pages>149-158</pages><issn>0282-0080</issn><eissn>1573-4986</eissn><abstract>Vascular calcification is an abnormal process in which bone specific hydroxyapatite crystals are actively deposited on the vascular wall mediated by phenotypic differentiated smooth muscle cells and other mesenchymal cells under various pathological conditions. It is one of the important characteristics in the occurrence and development of atherosclerosis, prevalent in patients with type 2 diabetes and advanced chronic kidney disease, especially those requiring maintenance hemodialysis, with severely threatening human health. Previous studies have shown that the early diagnosis and control of vascular calcification is of great significance for cardiovascular risk stratification, prevention of acute cardiovascular events, which can greatly improve the prognosis and quality of life of patients. Galectins are a family of lectin superfamily. It is widely distributed in various animals and plays an important role in many physiological and pathological processes, such as cell adhesion, apoptosis, inflammatory response, tumor metastasis and so on. Many biomarker-and association-related studies and Preclinical-mechanistic studies have suggested that galactose-specific lectin-3 (galectin-3) plays an important role in vascular calcification and vascular intimal calcification (VIC) calcification induced by Wnt/βcatenin signaling pathway, NF-κB signaling pathway and ERK1/2 signaling pathway. This paper mainly expounds the role and mechanism of galectin-3 in vascular calcification under different pathological conditions including atherosclerosis, diabetes and chronic kidney disease.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36807052</pmid><doi>10.1007/s10719-023-10106-x</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Apoptosis Arteriosclerosis Atherosclerosis Biochemistry Biomedical and Life Sciences Calcification Calcification (ectopic) Cardiovascular diseases Cell adhesion Cell differentiation Cells, Cultured Crystals Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Extracellular signal-regulated kinase Galactose Galectin 3 - adverse effects Galectin 3 - genetics Galectin 3 - metabolism Galectin-3 Galectins - genetics Hemodialysis Humans Hydroxyapatite Inflammation Kidney diseases Life Sciences Mesenchyme Metastases Mini Review NF-κB protein Pathology Quality of Life Renal Insufficiency, Chronic Signal transduction Smooth muscle Vascular Calcification - metabolism Vascular Calcification - pathology Vascular Calcification - prevention & control Wnt protein |
| title | Role of galectin-3 in vascular calcification |
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