Metabolic syndrome and the progression of knee osteoarthritis on MRI
Metabolic osteoarthritis (OA) is one of the proposed clinical phenotypes defined by the existence of metabolic syndrome (MetS). This study aimed to (1) investigate whether MetS and its components are associated with progression of knee OA magnetic resonance imaging (MRI) features, and (2) to evaluat...
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Veröffentlicht in: | Osteoarthritis and cartilage 2023-05, Vol.31 (5), p.647-655 |
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container_title | Osteoarthritis and cartilage |
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creator | Jansen, N.E.J. Molendijk, E. Schiphof, D. van Meurs, J.B.J. Oei, E.H.G. van Middelkoop, M. Bierma-Zeinstra, S.M.A. |
description | Metabolic osteoarthritis (OA) is one of the proposed clinical phenotypes defined by the existence of metabolic syndrome (MetS). This study aimed to (1) investigate whether MetS and its components are associated with progression of knee OA magnetic resonance imaging (MRI) features, and (2) to evaluate the interaction of MetS with menopause and progression of MRI features.
682 women from the Rotterdam Study who participated in a sub-study with knee MRI data available and 5-year follow-up were included. Tibiofemoral (TF) and patellofemoral (PF) OA features were assessed with the MRI Osteoarthritis Knee Score. MetS was quantified by the MetS severity Z-score. Generalized estimating equations were used to evaluate associations between MetS and menopausal transition and progression of MRI features.
MetS severity at baseline was associated with progression of osteophytes in all compartments, bone marrow lesions (BMLs) in the PF compartment, and cartilage defects in the medial TF compartment. Waist circumference was associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment. High-density lipoprotein (HDL)-cholesterol levels were associated with progression of osteophytes in the medial and lateral TF compartment and glucose levels with osteophytes in the PF and medial TF compartment. No interactions were found between MetS with menopausal transition and MRI features.
Women with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years. Further studies are required to understand whether targeting MetS components may prevent the progression of structural knee OA in women. |
doi_str_mv | 10.1016/j.joca.2023.02.003 |
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682 women from the Rotterdam Study who participated in a sub-study with knee MRI data available and 5-year follow-up were included. Tibiofemoral (TF) and patellofemoral (PF) OA features were assessed with the MRI Osteoarthritis Knee Score. MetS was quantified by the MetS severity Z-score. Generalized estimating equations were used to evaluate associations between MetS and menopausal transition and progression of MRI features.
MetS severity at baseline was associated with progression of osteophytes in all compartments, bone marrow lesions (BMLs) in the PF compartment, and cartilage defects in the medial TF compartment. Waist circumference was associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment. High-density lipoprotein (HDL)-cholesterol levels were associated with progression of osteophytes in the medial and lateral TF compartment and glucose levels with osteophytes in the PF and medial TF compartment. No interactions were found between MetS with menopausal transition and MRI features.
Women with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years. Further studies are required to understand whether targeting MetS components may prevent the progression of structural knee OA in women.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2023.02.003</identifier><identifier>PMID: 36801367</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cartilage Diseases - pathology ; Disease Progression ; Female ; Humans ; Knee Joint - diagnostic imaging ; Knee Joint - pathology ; Knee osteoarthritis ; Magnetic Resonance Imaging - methods ; Menopause ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - diagnostic imaging ; MRI features ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - pathology ; Osteophyte - pathology</subject><ispartof>Osteoarthritis and cartilage, 2023-05, Vol.31 (5), p.647-655</ispartof><rights>2023 The Author(s)</rights><rights>Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-4b2fa7047d84f0c7c7ea000d5e3359fd4320d7a63a041916b2706b6b272de5a3</citedby><cites>FETCH-LOGICAL-c400t-4b2fa7047d84f0c7c7ea000d5e3359fd4320d7a63a041916b2706b6b272de5a3</cites><orcidid>0000-0001-8804-9025 ; 0000-0002-1293-6346 ; 0000-0001-6926-0618 ; 0000-0003-3727-3427 ; 0000-0002-6800-6666</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joca.2023.02.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36801367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jansen, N.E.J.</creatorcontrib><creatorcontrib>Molendijk, E.</creatorcontrib><creatorcontrib>Schiphof, D.</creatorcontrib><creatorcontrib>van Meurs, J.B.J.</creatorcontrib><creatorcontrib>Oei, E.H.G.</creatorcontrib><creatorcontrib>van Middelkoop, M.</creatorcontrib><creatorcontrib>Bierma-Zeinstra, S.M.A.</creatorcontrib><title>Metabolic syndrome and the progression of knee osteoarthritis on MRI</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Metabolic osteoarthritis (OA) is one of the proposed clinical phenotypes defined by the existence of metabolic syndrome (MetS). This study aimed to (1) investigate whether MetS and its components are associated with progression of knee OA magnetic resonance imaging (MRI) features, and (2) to evaluate the interaction of MetS with menopause and progression of MRI features.
682 women from the Rotterdam Study who participated in a sub-study with knee MRI data available and 5-year follow-up were included. Tibiofemoral (TF) and patellofemoral (PF) OA features were assessed with the MRI Osteoarthritis Knee Score. MetS was quantified by the MetS severity Z-score. Generalized estimating equations were used to evaluate associations between MetS and menopausal transition and progression of MRI features.
MetS severity at baseline was associated with progression of osteophytes in all compartments, bone marrow lesions (BMLs) in the PF compartment, and cartilage defects in the medial TF compartment. Waist circumference was associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment. High-density lipoprotein (HDL)-cholesterol levels were associated with progression of osteophytes in the medial and lateral TF compartment and glucose levels with osteophytes in the PF and medial TF compartment. No interactions were found between MetS with menopausal transition and MRI features.
Women with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years. Further studies are required to understand whether targeting MetS components may prevent the progression of structural knee OA in women.</description><subject>Cartilage Diseases - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - pathology</subject><subject>Knee osteoarthritis</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Menopause</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - diagnostic imaging</subject><subject>MRI features</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteophyte - pathology</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwBzigHrm0OEnbtBIXNL4mbUJCu0dp4rKMrRlJh7R_T6YNjpxsyY9f2Q8h1xQyCrS8W2ZLp1XGgPEMWAbAT8iQFoyldVnw09hDydO8qPIBuQhhCZGgFM7JgJcVUF6KIXmcYa8at7I6CbvOeLfGRHUm6ReYbLz78BiCdV3i2uSzQ0xc6NEp3y-87W1I4mT2PrkkZ61aBbw61hGZPz_Nx6_p9O1lMn6YpjoH6NO8Ya0SkAtT5S1ooQWqeJMpkPOibk3OGRihSq4gpzUtGyagbPaFGSwUH5HbQ2w87GuLoZdrGzSuVqpDtw2SCVHVoipqiCg7oNq7EDy2cuPtWvmdpCD38uRS7uXJvTwJTEY1cenmmL9t1mj-Vn5tReD-AGB88tuil0Fb7DQa61H30jj7X_4PX_1_Sg</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Jansen, N.E.J.</creator><creator>Molendijk, E.</creator><creator>Schiphof, D.</creator><creator>van Meurs, J.B.J.</creator><creator>Oei, E.H.G.</creator><creator>van Middelkoop, M.</creator><creator>Bierma-Zeinstra, S.M.A.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8804-9025</orcidid><orcidid>https://orcid.org/0000-0002-1293-6346</orcidid><orcidid>https://orcid.org/0000-0001-6926-0618</orcidid><orcidid>https://orcid.org/0000-0003-3727-3427</orcidid><orcidid>https://orcid.org/0000-0002-6800-6666</orcidid></search><sort><creationdate>202305</creationdate><title>Metabolic syndrome and the progression of knee osteoarthritis on MRI</title><author>Jansen, N.E.J. ; Molendijk, E. ; Schiphof, D. ; van Meurs, J.B.J. ; Oei, E.H.G. ; van Middelkoop, M. ; Bierma-Zeinstra, S.M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-4b2fa7047d84f0c7c7ea000d5e3359fd4320d7a63a041916b2706b6b272de5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cartilage Diseases - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - pathology</topic><topic>Knee osteoarthritis</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Menopause</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - diagnostic imaging</topic><topic>MRI features</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteophyte - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansen, N.E.J.</creatorcontrib><creatorcontrib>Molendijk, E.</creatorcontrib><creatorcontrib>Schiphof, D.</creatorcontrib><creatorcontrib>van Meurs, J.B.J.</creatorcontrib><creatorcontrib>Oei, E.H.G.</creatorcontrib><creatorcontrib>van Middelkoop, M.</creatorcontrib><creatorcontrib>Bierma-Zeinstra, S.M.A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansen, N.E.J.</au><au>Molendijk, E.</au><au>Schiphof, D.</au><au>van Meurs, J.B.J.</au><au>Oei, E.H.G.</au><au>van Middelkoop, M.</au><au>Bierma-Zeinstra, S.M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome and the progression of knee osteoarthritis on MRI</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2023-05</date><risdate>2023</risdate><volume>31</volume><issue>5</issue><spage>647</spage><epage>655</epage><pages>647-655</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Metabolic osteoarthritis (OA) is one of the proposed clinical phenotypes defined by the existence of metabolic syndrome (MetS). This study aimed to (1) investigate whether MetS and its components are associated with progression of knee OA magnetic resonance imaging (MRI) features, and (2) to evaluate the interaction of MetS with menopause and progression of MRI features.
682 women from the Rotterdam Study who participated in a sub-study with knee MRI data available and 5-year follow-up were included. Tibiofemoral (TF) and patellofemoral (PF) OA features were assessed with the MRI Osteoarthritis Knee Score. MetS was quantified by the MetS severity Z-score. Generalized estimating equations were used to evaluate associations between MetS and menopausal transition and progression of MRI features.
MetS severity at baseline was associated with progression of osteophytes in all compartments, bone marrow lesions (BMLs) in the PF compartment, and cartilage defects in the medial TF compartment. Waist circumference was associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment. High-density lipoprotein (HDL)-cholesterol levels were associated with progression of osteophytes in the medial and lateral TF compartment and glucose levels with osteophytes in the PF and medial TF compartment. No interactions were found between MetS with menopausal transition and MRI features.
Women with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years. Further studies are required to understand whether targeting MetS components may prevent the progression of structural knee OA in women.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36801367</pmid><doi>10.1016/j.joca.2023.02.003</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8804-9025</orcidid><orcidid>https://orcid.org/0000-0002-1293-6346</orcidid><orcidid>https://orcid.org/0000-0001-6926-0618</orcidid><orcidid>https://orcid.org/0000-0003-3727-3427</orcidid><orcidid>https://orcid.org/0000-0002-6800-6666</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cartilage Diseases - pathology Disease Progression Female Humans Knee Joint - diagnostic imaging Knee Joint - pathology Knee osteoarthritis Magnetic Resonance Imaging - methods Menopause Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - diagnostic imaging MRI features Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - pathology Osteophyte - pathology |
title | Metabolic syndrome and the progression of knee osteoarthritis on MRI |
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