Tandem Repeat Generation and Novel Isothermal Amplification Based on Nonspecific Tailing and Replication Slippage

Abstract Background Isothermal amplification is considered to be one of the most promising tools for point-of-care testing molecular diagnosis. However, its clinical application is severely hindered by nonspecific amplification. Thus, it is important to investigate the exact mechanism of nonspecific...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2023-04, Vol.69 (4), p.363-373
Hauptverfasser:	Luo, Guangcheng, He, Hongfei, Wang, Dongsheng, Liu, Shanshan, Tian, Shisu, Chen, Miaomiao, Wang, Qiang, Zhao, Changsong, Leng, Zhengwei, Hou, Lingmi, Guo, Xiaolan
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA DNA Primers - genetics DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Humans Nucleic Acid Amplification Techniques - methods Sensitivity and Specificity Tandem Repeat Sequences
Online-Zugang:	Volltext
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