Tyrosine‐Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal–Organic Framework Composites as Electrochemical Tags

Beta‐site secretase (BACE1) catalyzes the cleavage of amyloid precursor protein (APP), which process ultimately lead to plaque deposition in the brain of Alzheimer's disease (AD). Thus, accurate monitor of BACE1 activity is essential to screen inhibitors for AD treatment. This study develops a...

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Veröffentlicht in:	Chemistry : a European journal 2023-05, Vol.29 (28), p.e202300450-n/a
Hauptverfasser:	Zhou, Yanli, Huang, Zihan, Liu, Jiaxiang, Dong, Hui, Zhang, Yintang, Xu, Maotian, Bi, Yanfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases beta-site secretase Chemistry Cleavage Composite materials Conjugation Cytosine electrochemical tags Electrochemistry Graphene Humans Metal Nanoparticles Metal-Organic Frameworks Nanoparticles Neurodegenerative diseases Phenolic compounds Phenols Secretase Silver silver nanoparticles Tags Tyrosine tyrosine conjugation Zirconium β-Site APP-cleaving enzyme 1
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