CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren’s Syndrome by Activating GRK2 to Promote T Lymphocyte Migration

Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease that causes dysfunction of secretory glands and the specific pathogenesis is still unknown. The CXCL9, 10, 11/CXCR3 axis and G protein-coupled receptor kinase 2 (GRK2) involved in many inflammation and immunity processes. We used NOD/...

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Veröffentlicht in:	Inflammation 2023-06, Vol.46 (3), p.1047-1060
Hauptverfasser:	Zhang, Jing, Zhang, Xiao, Shi, Xingjie, Liu, Yuqi, Cheng, Danqian, Tian, Qianwen, Lin, Ning, Wei, Wei, Wu, Huaxun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Autoimmune diseases b-Adrenergic-receptor kinase Biomedical and Life Sciences Biomedicine CD4 antigen Cell membranes Cell Movement Chemokine CXCL9 CXCR3 protein Epithelial cells G protein-coupled receptor kinase G protein-coupled receptor kinase 2 Helper cells Humans Immunology Internal Medicine Janus kinase 2 Kinases Leukocyte migration Lymphocytes Lymphocytes T Mice Mice, Inbred ICR Mice, Inbred NOD Original Article Pathology Pharmacology/Toxicology Receptors, CXCR3 - metabolism Rheumatology Salivary gland siRNA Sjogren's syndrome Sjogren's Syndrome - metabolism Spleen Stat1 protein Submandibular gland T-Lymphocytes, Regulatory - metabolism γ-Interferon
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