In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD

Mislocalization and aggregate formation of TAR DNA-biding protein of 43kD (TDP-43) in the cytoplasm are signatures of amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration (FTLD). However, the role of two cytopathologies in ALS/FTLD pathogenesis is unclear. This study aims to eluc...

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Veröffentlicht in:	Neuroscience research 2023-08, Vol.193, p.41-51
Hauptverfasser:	Wada, Hideki, Hikiami, Ryota, Kusui, Makiko, Minamiyama, Sumio, Asada-Utsugi, Megumi, Shodai, Akemi, Muramatsu, Shin-ichi, Morimura, Toshifumi, Urushitani, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amyotrophic lateral sclerosis (ALS) Amyotrophic Lateral Sclerosis - genetics Animals Cerebral Cortex - metabolism DNA-Binding Proteins - metabolism Frontotemporal Lobar Degeneration - genetics Frontotemporal lobar degeneration FTLD Humans Mice Mice, Transgenic Neurons - metabolism Nucleus localizing signal (NLS) TAR DNA-binding protein 43kDa (TDP-43)
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