Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery
[Display omitted] The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical s...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2023-05, Vol.638, p.122740-122740, Article 122740 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 122740 |
|---|---|
| container_issue | |
| container_start_page | 122740 |
| container_title | International journal of pharmaceutics |
| container_volume | 638 |
| creator | Abdi, Behnam Mofidfar, Mohammad Hassanpour, Fatemeh Kirbas Cilingir, Emel Kalajahi, Sepideh K. Milani, Paria H. Ghanbarzadeh, Mahsa Fadel, Daddi Barnett, Melissa Ta, Christopher N. Leblanc, Roger M. Chauhan, Anuj Abbasi, Farhang |
| description | [Display omitted]
The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical sciences. Since traditional methods are less efficient (∼5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. The main techniques used to achieve sustained release are discussed in this review, including soaking in drug solutions, incorporating drug into multilayered contact lenses, use of vitamin E barriers, molecular imprinting, nanoparticles, micelles and liposomes. The most clinically relevant results on different eye pathologies are presented. In addition, this review summarizes the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses to achieve sustained release, results of in vitro and in vivo studies, and recent advances in the commercialization of therapeutic contact lenses for allergic conjunctivitis. |
| doi_str_mv | 10.1016/j.ijpharm.2023.122740 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2778975783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517323001606</els_id><sourcerecordid>2778975783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-741b9331147ad8a506826b7e4497dae7bb77a1d012bdeb4efa4361601373ae083</originalsourceid><addsrcrecordid>eNqFkc1P3DAQxa2qqCy0f0IrH3vJ1l-Js1wqhPiSkHqBszWxJ6xXibPYzgru_OEYdttrT6ORfu-N5j1CvnO25Iw3vzZLv9muIY5LwYRcciG0Yp_IgrdaVlLp5jNZMKnbquZaHpOTlDaMsUZw-YUcy6ZlqhZqQV7v1xhhi3P2ltopZLCZDhgSJtpPkeY10hwR8ogh06kvTAwIA4Xg6GTnASJNc-zBInU-IRThGT13Owi2WPhA8TljcOg-FBniI-ayuDg_UoeD32F8-UqOehgSfjvMU_JwdXl_cVPd_bm-vTi_q6ySPFda8W4lJedKg2uhZk0rmk6jUivtAHXXaQ3cMS46h53CHpRseMO41BKQtfKU_Nz7buP0NGPKZvTJ4jBAwGlORmjdrnStW1nQeo_aOKUUsTfb6EeIL4Yz816A2ZhDAea9ALMvoOh-HE7M3Yjun-pv4gX4vQewPLrzGE2yHktYzke02bjJ_-fEG0IAm1s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2778975783</pqid></control><display><type>article</type><title>Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Abdi, Behnam ; Mofidfar, Mohammad ; Hassanpour, Fatemeh ; Kirbas Cilingir, Emel ; Kalajahi, Sepideh K. ; Milani, Paria H. ; Ghanbarzadeh, Mahsa ; Fadel, Daddi ; Barnett, Melissa ; Ta, Christopher N. ; Leblanc, Roger M. ; Chauhan, Anuj ; Abbasi, Farhang</creator><creatorcontrib>Abdi, Behnam ; Mofidfar, Mohammad ; Hassanpour, Fatemeh ; Kirbas Cilingir, Emel ; Kalajahi, Sepideh K. ; Milani, Paria H. ; Ghanbarzadeh, Mahsa ; Fadel, Daddi ; Barnett, Melissa ; Ta, Christopher N. ; Leblanc, Roger M. ; Chauhan, Anuj ; Abbasi, Farhang</creatorcontrib><description>[Display omitted]
The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical sciences. Since traditional methods are less efficient (∼5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. The main techniques used to achieve sustained release are discussed in this review, including soaking in drug solutions, incorporating drug into multilayered contact lenses, use of vitamin E barriers, molecular imprinting, nanoparticles, micelles and liposomes. The most clinically relevant results on different eye pathologies are presented. In addition, this review summarizes the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses to achieve sustained release, results of in vitro and in vivo studies, and recent advances in the commercialization of therapeutic contact lenses for allergic conjunctivitis.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2023.122740</identifier><identifier>PMID: 36804524</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Ophthalmic ; Anterior eye segment ; Contact Lenses, Hydrophilic ; Cornea ; Delayed-Action Preparations - therapeutic use ; Drug Delivery Systems - methods ; Eye Diseases - drug therapy ; Humans ; Sustained release ; Targeted drug delivery ; Therapeutic contact lenses ; Therapeutic scleral lenses</subject><ispartof>International journal of pharmaceutics, 2023-05, Vol.638, p.122740-122740, Article 122740</ispartof><rights>2023</rights><rights>Crown Copyright © 2023. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-741b9331147ad8a506826b7e4497dae7bb77a1d012bdeb4efa4361601373ae083</citedby><cites>FETCH-LOGICAL-c431t-741b9331147ad8a506826b7e4497dae7bb77a1d012bdeb4efa4361601373ae083</cites><orcidid>0000-0002-7160-8967 ; 0000-0001-9770-4255 ; 0000-0001-8862-7315 ; 0000-0001-8132-4434 ; 0000-0003-4878-9832 ; 0000-0001-6194-0758 ; 0000-0001-8836-8042 ; 0000-0001-7864-2490 ; 0000-0002-5691-9855 ; 0000-0001-8949-5393 ; 0000-0001-8079-8080 ; 0000-0002-1920-2900 ; 0000-0002-3312-8292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517323001606$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36804524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdi, Behnam</creatorcontrib><creatorcontrib>Mofidfar, Mohammad</creatorcontrib><creatorcontrib>Hassanpour, Fatemeh</creatorcontrib><creatorcontrib>Kirbas Cilingir, Emel</creatorcontrib><creatorcontrib>Kalajahi, Sepideh K.</creatorcontrib><creatorcontrib>Milani, Paria H.</creatorcontrib><creatorcontrib>Ghanbarzadeh, Mahsa</creatorcontrib><creatorcontrib>Fadel, Daddi</creatorcontrib><creatorcontrib>Barnett, Melissa</creatorcontrib><creatorcontrib>Ta, Christopher N.</creatorcontrib><creatorcontrib>Leblanc, Roger M.</creatorcontrib><creatorcontrib>Chauhan, Anuj</creatorcontrib><creatorcontrib>Abbasi, Farhang</creatorcontrib><title>Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical sciences. Since traditional methods are less efficient (∼5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. The main techniques used to achieve sustained release are discussed in this review, including soaking in drug solutions, incorporating drug into multilayered contact lenses, use of vitamin E barriers, molecular imprinting, nanoparticles, micelles and liposomes. The most clinically relevant results on different eye pathologies are presented. In addition, this review summarizes the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses to achieve sustained release, results of in vitro and in vivo studies, and recent advances in the commercialization of therapeutic contact lenses for allergic conjunctivitis.</description><subject>Administration, Ophthalmic</subject><subject>Anterior eye segment</subject><subject>Contact Lenses, Hydrophilic</subject><subject>Cornea</subject><subject>Delayed-Action Preparations - therapeutic use</subject><subject>Drug Delivery Systems - methods</subject><subject>Eye Diseases - drug therapy</subject><subject>Humans</subject><subject>Sustained release</subject><subject>Targeted drug delivery</subject><subject>Therapeutic contact lenses</subject><subject>Therapeutic scleral lenses</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxa2qqCy0f0IrH3vJ1l-Js1wqhPiSkHqBszWxJ6xXibPYzgru_OEYdttrT6ORfu-N5j1CvnO25Iw3vzZLv9muIY5LwYRcciG0Yp_IgrdaVlLp5jNZMKnbquZaHpOTlDaMsUZw-YUcy6ZlqhZqQV7v1xhhi3P2ltopZLCZDhgSJtpPkeY10hwR8ogh06kvTAwIA4Xg6GTnASJNc-zBInU-IRThGT13Owi2WPhA8TljcOg-FBniI-ayuDg_UoeD32F8-UqOehgSfjvMU_JwdXl_cVPd_bm-vTi_q6ySPFda8W4lJedKg2uhZk0rmk6jUivtAHXXaQ3cMS46h53CHpRseMO41BKQtfKU_Nz7buP0NGPKZvTJ4jBAwGlORmjdrnStW1nQeo_aOKUUsTfb6EeIL4Yz816A2ZhDAea9ALMvoOh-HE7M3Yjun-pv4gX4vQewPLrzGE2yHktYzke02bjJ_-fEG0IAm1s</recordid><startdate>20230510</startdate><enddate>20230510</enddate><creator>Abdi, Behnam</creator><creator>Mofidfar, Mohammad</creator><creator>Hassanpour, Fatemeh</creator><creator>Kirbas Cilingir, Emel</creator><creator>Kalajahi, Sepideh K.</creator><creator>Milani, Paria H.</creator><creator>Ghanbarzadeh, Mahsa</creator><creator>Fadel, Daddi</creator><creator>Barnett, Melissa</creator><creator>Ta, Christopher N.</creator><creator>Leblanc, Roger M.</creator><creator>Chauhan, Anuj</creator><creator>Abbasi, Farhang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7160-8967</orcidid><orcidid>https://orcid.org/0000-0001-9770-4255</orcidid><orcidid>https://orcid.org/0000-0001-8862-7315</orcidid><orcidid>https://orcid.org/0000-0001-8132-4434</orcidid><orcidid>https://orcid.org/0000-0003-4878-9832</orcidid><orcidid>https://orcid.org/0000-0001-6194-0758</orcidid><orcidid>https://orcid.org/0000-0001-8836-8042</orcidid><orcidid>https://orcid.org/0000-0001-7864-2490</orcidid><orcidid>https://orcid.org/0000-0002-5691-9855</orcidid><orcidid>https://orcid.org/0000-0001-8949-5393</orcidid><orcidid>https://orcid.org/0000-0001-8079-8080</orcidid><orcidid>https://orcid.org/0000-0002-1920-2900</orcidid><orcidid>https://orcid.org/0000-0002-3312-8292</orcidid></search><sort><creationdate>20230510</creationdate><title>Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery</title><author>Abdi, Behnam ; Mofidfar, Mohammad ; Hassanpour, Fatemeh ; Kirbas Cilingir, Emel ; Kalajahi, Sepideh K. ; Milani, Paria H. ; Ghanbarzadeh, Mahsa ; Fadel, Daddi ; Barnett, Melissa ; Ta, Christopher N. ; Leblanc, Roger M. ; Chauhan, Anuj ; Abbasi, Farhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-741b9331147ad8a506826b7e4497dae7bb77a1d012bdeb4efa4361601373ae083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Administration, Ophthalmic</topic><topic>Anterior eye segment</topic><topic>Contact Lenses, Hydrophilic</topic><topic>Cornea</topic><topic>Delayed-Action Preparations - therapeutic use</topic><topic>Drug Delivery Systems - methods</topic><topic>Eye Diseases - drug therapy</topic><topic>Humans</topic><topic>Sustained release</topic><topic>Targeted drug delivery</topic><topic>Therapeutic contact lenses</topic><topic>Therapeutic scleral lenses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdi, Behnam</creatorcontrib><creatorcontrib>Mofidfar, Mohammad</creatorcontrib><creatorcontrib>Hassanpour, Fatemeh</creatorcontrib><creatorcontrib>Kirbas Cilingir, Emel</creatorcontrib><creatorcontrib>Kalajahi, Sepideh K.</creatorcontrib><creatorcontrib>Milani, Paria H.</creatorcontrib><creatorcontrib>Ghanbarzadeh, Mahsa</creatorcontrib><creatorcontrib>Fadel, Daddi</creatorcontrib><creatorcontrib>Barnett, Melissa</creatorcontrib><creatorcontrib>Ta, Christopher N.</creatorcontrib><creatorcontrib>Leblanc, Roger M.</creatorcontrib><creatorcontrib>Chauhan, Anuj</creatorcontrib><creatorcontrib>Abbasi, Farhang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdi, Behnam</au><au>Mofidfar, Mohammad</au><au>Hassanpour, Fatemeh</au><au>Kirbas Cilingir, Emel</au><au>Kalajahi, Sepideh K.</au><au>Milani, Paria H.</au><au>Ghanbarzadeh, Mahsa</au><au>Fadel, Daddi</au><au>Barnett, Melissa</au><au>Ta, Christopher N.</au><au>Leblanc, Roger M.</au><au>Chauhan, Anuj</au><au>Abbasi, Farhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2023-05-10</date><risdate>2023</risdate><volume>638</volume><spage>122740</spage><epage>122740</epage><pages>122740-122740</pages><artnum>122740</artnum><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical sciences. Since traditional methods are less efficient (∼5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. The main techniques used to achieve sustained release are discussed in this review, including soaking in drug solutions, incorporating drug into multilayered contact lenses, use of vitamin E barriers, molecular imprinting, nanoparticles, micelles and liposomes. The most clinically relevant results on different eye pathologies are presented. In addition, this review summarizes the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses to achieve sustained release, results of in vitro and in vivo studies, and recent advances in the commercialization of therapeutic contact lenses for allergic conjunctivitis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36804524</pmid><doi>10.1016/j.ijpharm.2023.122740</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7160-8967</orcidid><orcidid>https://orcid.org/0000-0001-9770-4255</orcidid><orcidid>https://orcid.org/0000-0001-8862-7315</orcidid><orcidid>https://orcid.org/0000-0001-8132-4434</orcidid><orcidid>https://orcid.org/0000-0003-4878-9832</orcidid><orcidid>https://orcid.org/0000-0001-6194-0758</orcidid><orcidid>https://orcid.org/0000-0001-8836-8042</orcidid><orcidid>https://orcid.org/0000-0001-7864-2490</orcidid><orcidid>https://orcid.org/0000-0002-5691-9855</orcidid><orcidid>https://orcid.org/0000-0001-8949-5393</orcidid><orcidid>https://orcid.org/0000-0001-8079-8080</orcidid><orcidid>https://orcid.org/0000-0002-1920-2900</orcidid><orcidid>https://orcid.org/0000-0002-3312-8292</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2023-05, Vol.638, p.122740-122740, Article 122740 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2778975783 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Ophthalmic Anterior eye segment Contact Lenses, Hydrophilic Cornea Delayed-Action Preparations - therapeutic use Drug Delivery Systems - methods Eye Diseases - drug therapy Humans Sustained release Targeted drug delivery Therapeutic contact lenses Therapeutic scleral lenses |
| title | Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T13%3A07%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20contact%20lenses%20for%20the%20treatment%20of%20corneal%20and%20ocular%20surface%20diseases:%20Advances%20in%20extended%20and%20targeted%20drug%20delivery&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Abdi,%20Behnam&rft.date=2023-05-10&rft.volume=638&rft.spage=122740&rft.epage=122740&rft.pages=122740-122740&rft.artnum=122740&rft.issn=0378-5173&rft.eissn=1873-3476&rft_id=info:doi/10.1016/j.ijpharm.2023.122740&rft_dat=%3Cproquest_cross%3E2778975783%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2778975783&rft_id=info:pmid/36804524&rft_els_id=S0378517323001606&rfr_iscdi=true |