Chaperone-mediated production of active homodimer human bone morphogenetic protein – 2 in E. coli

Human bone morphogenetic protein 2 (hBMP-2) plays a leading role in the process of osteogenesis and is one of the key components of osteoplastic materials, ensuring their high osteoinduction. In order to obtain a homodimeric form hBMP-2 using the E. coli expression system, a number of problems assoc...

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Veröffentlicht in:	Protein expression and purification 2023-06, Vol.206, p.106245-106245, Article 106245
Hauptverfasser:	Lykoshin, Dmitry D., Kostromina, Maria A., Azmukova, Veronika R., Esipov, Roman S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 2 - chemistry Bone Morphogenetic Protein 7 - metabolism Escherichia coli - genetics Escherichia coli - metabolism Homodimeric protein Humans Molecular Chaperones - genetics Molecular Chaperones - metabolism Osteogenesis Osteogenic activity Protein purification Recombinant human bone morphogenetic protein (rhBMP-2) Recombinant Proteins - chemistry Soluble expression
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