High Protein Whole Food Snack and Albumin Outcomes in Patients With Dialysis-Dependent Chronic Kidney Disease
Protein-energy wasting is common among patients on hemodialysis (HD). This study sought to define effects that a novel, post-HD, high-calorie, high-protein whole food snack had on patients’ serum albumin (serum alb), serum phosphorus and equilibrated normalized protein catabolic rate (enPCR). A 12-m...
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| Veröffentlicht in: | Journal of renal nutrition 2023-07, Vol.33 (4), p.601-609 |
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| creator | Parker, Jennifer Rose Andrade, Jeanette M. Tibbetts, John Jiao, Yue Larkin, John W. Hymes, Jeffrey L. |
| description | Protein-energy wasting is common among patients on hemodialysis (HD). This study sought to define effects that a novel, post-HD, high-calorie, high-protein whole food snack had on patients’ serum albumin (serum alb), serum phosphorus and equilibrated normalized protein catabolic rate (enPCR).
A 12-month (6 months intervention, 6 months pre/post data collection), single-center, unblinded study was conducted. Participants (n = 67) consumed, ad libitum, a whole food snack post-HD for 6 treatments each month. Upon analysis, regression models identified relationships between serum alb and whole food snack consumption across follow up. Predefined effect size anticipated was + 0.2 g/dL. Patients were stratified by high (≥4 g/dL) or low ( |
| doi_str_mv | 10.1053/j.jrn.2023.02.003 |
| format | Article |
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A 12-month (6 months intervention, 6 months pre/post data collection), single-center, unblinded study was conducted. Participants (n = 67) consumed, ad libitum, a whole food snack post-HD for 6 treatments each month. Upon analysis, regression models identified relationships between serum alb and whole food snack consumption across follow up. Predefined effect size anticipated was + 0.2 g/dL. Patients were stratified by high (≥4 g/dL) or low (<4 g/dL) mean serum alb during a 3-month baseline period. Paired t-tests compared mean per patient difference in serum alb, enPCR and serum phosphorus from baseline to each month of follow up, stratified by high (≥640 g) or low (<640 g) consumption of the whole food snack (a priori caloric estimation).
Linear regression models showed positive associations between higher serum alb and enPCR with higher whole food snack consumption across follow up (all P < .05). Assessments from baseline to each follow-up month show some increases in serum alb, yet t test comparisons were not significant. No significant changes were seen in serum phosphorus levels during follow-up.
Albeit the catabolic effects of HD are well-known, effective nutritional interventions are scarce. Results showed that providing a whole food snack post-HD to individuals with serum alb <4.0 g/dL may be beneficial but further studies are recommended.</description><identifier>ISSN: 1051-2276</identifier><identifier>EISSN: 1532-8503</identifier><identifier>DOI: 10.1053/j.jrn.2023.02.003</identifier><identifier>PMID: 36805102</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>equilibrated normalized Protein Catabolic Rate ; hemodialysis ; high-protein whole food snack ; Humans ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Phosphorus ; Renal Dialysis ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Serum albumin ; Serum Albumin - metabolism ; Serum phosphorus ; Snacks</subject><ispartof>Journal of renal nutrition, 2023-07, Vol.33 (4), p.601-609</ispartof><rights>2023 National Kidney Foundation, Inc.</rights><rights>Copyright © 2023 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c268t-f2cac45ef6d6d4dfe02d18d79e2151a9418d3e77601c4a4bc0e49cb18d29821a3</citedby><cites>FETCH-LOGICAL-c268t-f2cac45ef6d6d4dfe02d18d79e2151a9418d3e77601c4a4bc0e49cb18d29821a3</cites><orcidid>0000-0003-4452-4546 ; 0000-0002-5705-9789 ; 0000-0001-7859-9218 ; 0000-0001-8873-8971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1051227623000237$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36805102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parker, Jennifer Rose</creatorcontrib><creatorcontrib>Andrade, Jeanette M.</creatorcontrib><creatorcontrib>Tibbetts, John</creatorcontrib><creatorcontrib>Jiao, Yue</creatorcontrib><creatorcontrib>Larkin, John W.</creatorcontrib><creatorcontrib>Hymes, Jeffrey L.</creatorcontrib><title>High Protein Whole Food Snack and Albumin Outcomes in Patients With Dialysis-Dependent Chronic Kidney Disease</title><title>Journal of renal nutrition</title><addtitle>J Ren Nutr</addtitle><description>Protein-energy wasting is common among patients on hemodialysis (HD). This study sought to define effects that a novel, post-HD, high-calorie, high-protein whole food snack had on patients’ serum albumin (serum alb), serum phosphorus and equilibrated normalized protein catabolic rate (enPCR).
A 12-month (6 months intervention, 6 months pre/post data collection), single-center, unblinded study was conducted. Participants (n = 67) consumed, ad libitum, a whole food snack post-HD for 6 treatments each month. Upon analysis, regression models identified relationships between serum alb and whole food snack consumption across follow up. Predefined effect size anticipated was + 0.2 g/dL. Patients were stratified by high (≥4 g/dL) or low (<4 g/dL) mean serum alb during a 3-month baseline period. Paired t-tests compared mean per patient difference in serum alb, enPCR and serum phosphorus from baseline to each month of follow up, stratified by high (≥640 g) or low (<640 g) consumption of the whole food snack (a priori caloric estimation).
Linear regression models showed positive associations between higher serum alb and enPCR with higher whole food snack consumption across follow up (all P < .05). Assessments from baseline to each follow-up month show some increases in serum alb, yet t test comparisons were not significant. No significant changes were seen in serum phosphorus levels during follow-up.
Albeit the catabolic effects of HD are well-known, effective nutritional interventions are scarce. Results showed that providing a whole food snack post-HD to individuals with serum alb <4.0 g/dL may be beneficial but further studies are recommended.</description><subject>equilibrated normalized Protein Catabolic Rate</subject><subject>hemodialysis</subject><subject>high-protein whole food snack</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Phosphorus</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Serum albumin</subject><subject>Serum Albumin - metabolism</subject><subject>Serum phosphorus</subject><subject>Snacks</subject><issn>1051-2276</issn><issn>1532-8503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1uGyEURlGVKnHSPEA3EctsZgqX-VVXlhMnVS0lUlt5iTDciXFnwIWZSH77YDntsisufOd-EoeQz5zlnJXiyy7fBZcDA5EzyBkTH8iMlwKypmTiLM2s5BlAXV2Qyxh3jHFeNnBOLkTVpIjBjAyP9mVLn4Mf0Tq63voe6dJ7Q384pX9T5Qyd95tpSOHTNGo_YKRpflajRTdGurbjlt5Z1R-ijdkd7tGZFNDFNnhnNf1ujcNDIiKqiJ_Ix071Ea_fzyvya3n_c_GYrZ4evi3mq0xD1YxZB1rposSuMpUpTIcMDG9M3SLwkqu2SBeBdV0xrgtVbDTDotWb9AptA1yJK3J76t0H_2fCOMrBRo19rxz6KUqo66atSyEgofyE6uBjDNjJfbCDCgfJmTxaljuZLMujZclAJstp5-a9ftoMaP5t_NWagK8nANMnXy0GGXXypdHYgHqUxtv_1L8Bc_iNbg</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Parker, Jennifer Rose</creator><creator>Andrade, Jeanette M.</creator><creator>Tibbetts, John</creator><creator>Jiao, Yue</creator><creator>Larkin, John W.</creator><creator>Hymes, Jeffrey L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4452-4546</orcidid><orcidid>https://orcid.org/0000-0002-5705-9789</orcidid><orcidid>https://orcid.org/0000-0001-7859-9218</orcidid><orcidid>https://orcid.org/0000-0001-8873-8971</orcidid></search><sort><creationdate>202307</creationdate><title>High Protein Whole Food Snack and Albumin Outcomes in Patients With Dialysis-Dependent Chronic Kidney Disease</title><author>Parker, Jennifer Rose ; Andrade, Jeanette M. ; Tibbetts, John ; Jiao, Yue ; Larkin, John W. ; Hymes, Jeffrey L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-f2cac45ef6d6d4dfe02d18d79e2151a9418d3e77601c4a4bc0e49cb18d29821a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>equilibrated normalized Protein Catabolic Rate</topic><topic>hemodialysis</topic><topic>high-protein whole food snack</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Phosphorus</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Serum albumin</topic><topic>Serum Albumin - metabolism</topic><topic>Serum phosphorus</topic><topic>Snacks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parker, Jennifer Rose</creatorcontrib><creatorcontrib>Andrade, Jeanette M.</creatorcontrib><creatorcontrib>Tibbetts, John</creatorcontrib><creatorcontrib>Jiao, Yue</creatorcontrib><creatorcontrib>Larkin, John W.</creatorcontrib><creatorcontrib>Hymes, Jeffrey L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of renal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parker, Jennifer Rose</au><au>Andrade, Jeanette M.</au><au>Tibbetts, John</au><au>Jiao, Yue</au><au>Larkin, John W.</au><au>Hymes, Jeffrey L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Protein Whole Food Snack and Albumin Outcomes in Patients With Dialysis-Dependent Chronic Kidney Disease</atitle><jtitle>Journal of renal nutrition</jtitle><addtitle>J Ren Nutr</addtitle><date>2023-07</date><risdate>2023</risdate><volume>33</volume><issue>4</issue><spage>601</spage><epage>609</epage><pages>601-609</pages><issn>1051-2276</issn><eissn>1532-8503</eissn><abstract>Protein-energy wasting is common among patients on hemodialysis (HD). This study sought to define effects that a novel, post-HD, high-calorie, high-protein whole food snack had on patients’ serum albumin (serum alb), serum phosphorus and equilibrated normalized protein catabolic rate (enPCR).
A 12-month (6 months intervention, 6 months pre/post data collection), single-center, unblinded study was conducted. Participants (n = 67) consumed, ad libitum, a whole food snack post-HD for 6 treatments each month. Upon analysis, regression models identified relationships between serum alb and whole food snack consumption across follow up. Predefined effect size anticipated was + 0.2 g/dL. Patients were stratified by high (≥4 g/dL) or low (<4 g/dL) mean serum alb during a 3-month baseline period. Paired t-tests compared mean per patient difference in serum alb, enPCR and serum phosphorus from baseline to each month of follow up, stratified by high (≥640 g) or low (<640 g) consumption of the whole food snack (a priori caloric estimation).
Linear regression models showed positive associations between higher serum alb and enPCR with higher whole food snack consumption across follow up (all P < .05). Assessments from baseline to each follow-up month show some increases in serum alb, yet t test comparisons were not significant. No significant changes were seen in serum phosphorus levels during follow-up.
Albeit the catabolic effects of HD are well-known, effective nutritional interventions are scarce. Results showed that providing a whole food snack post-HD to individuals with serum alb <4.0 g/dL may be beneficial but further studies are recommended.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36805102</pmid><doi>10.1053/j.jrn.2023.02.003</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4452-4546</orcidid><orcidid>https://orcid.org/0000-0002-5705-9789</orcidid><orcidid>https://orcid.org/0000-0001-7859-9218</orcidid><orcidid>https://orcid.org/0000-0001-8873-8971</orcidid></addata></record> |
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| subjects | equilibrated normalized Protein Catabolic Rate hemodialysis high-protein whole food snack Humans Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Phosphorus Renal Dialysis Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Serum albumin Serum Albumin - metabolism Serum phosphorus Snacks |
| title | High Protein Whole Food Snack and Albumin Outcomes in Patients With Dialysis-Dependent Chronic Kidney Disease |
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