Assessment of the role of nucleoside transporters, P-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in the placental transport of entecavir using in vitro, ex vivo, and in situ methods

The nucleoside analog entecavir (ETV) is a first-line pharmacotherapy for chronic hepatitis B in adult and pediatric patients. However, due to insufficient data on placental transfer and its effects on pregnancy, ETV administration is not recommended for women after conception. To expand knowledge o...

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Veröffentlicht in:	Toxicology and applied pharmacology 2023-03, Vol.463, p.116427-116427, Article 116427
Hauptverfasser:	Cerveny, Lukas, Karbanova, Sara, Karahoda, Rona, Horackova, Hana, Jiraskova, Lucie, Ali, Mohammed Naji Husaen, Staud, Frantisek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism ATP-binding cassette transporters Breast Neoplasms - metabolism Child Concentrative nucleoside transporters Entecavir Equilibrative nucleoside transporters Female Humans Membrane Transport Proteins - metabolism Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - metabolism Nucleoside Transport Proteins - metabolism Nucleoside Transport Proteins - pharmacology Nucleosides - metabolism Nucleosides - pharmacology Placenta - metabolism Placental transfer Pregnancy Rats Rats, Wistar Uridine
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