Mendelian inheritance revisited: dominance and recessiveness in medical genetics

Understanding the consequences of genotype for phenotype (which ranges from molecule-level effects to whole-organism traits) is at the core of genetic diagnostics in medicine. Many measures of the deleteriousness of individual alleles exist, but these have limitations for predicting the clinical con...

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Veröffentlicht in:	Nature reviews. Genetics 2023-07, Vol.24 (7), p.442-463
Hauptverfasser:	Zschocke, Johannes, Byers, Peter H., Wilkie, Andrew O. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/1516 631/208/2489/144 631/208/726/649 631/208/737 Agriculture Alleles Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Disease DNA sequencing Drug dosages Gene Function Genes Genetic disorders Genetic screening Genetics Genetics, Medical Genotype Genotype & phenotype Genotypes Heredity Human Genetics Medicine Mutation Phenotype Phenotypes Proteins Review Article
Online-Zugang:	Volltext
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