Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets

Diabetes and metabolic perturbation are global health challenges. Sleep insufficiency may trigger metabolic dysregulation leading to diabetes. However, the intergenerational transmission of this environmental information is not clearly understood. The research objective was to determine the possible...

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Veröffentlicht in:	Journal of pineal research 2023-05, Vol.74 (4), p.e12863-n/a
Hauptverfasser:	Zeng, Yi, Zhang, Zhen, Liang, SiTing, Chang, XinMiao, Qin, RuiJie, Chen, Hong, Guo, LiXin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin D1 - pharmacology Cyclin D2 - genetics Cyclin D2 - metabolism Cyclin D2 - pharmacology diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism DNA Methylation Fathers glucose intolerance Glucose Intolerance - genetics Humans Islets of Langerhans - metabolism Low Density Lipoprotein Receptor-Related Protein-5 - genetics Low Density Lipoprotein Receptor-Related Protein-5 - metabolism Male Melatonin - pharmacology Mice Sleep Deprivation
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