The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury

The prognosis of myocardial ischemia/reperfusion (I/R) injury is poor in elderly patients. Aging increases the susceptibility of the heart to cell death from I/R injury and prevents the optimal effectiveness of cardioprotective modalities. Since the interaction of aging with cardioprotection is mult...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2023-08, Vol.396 (8), p.1701-1711
Hauptverfasser:	Mokhtari, Behnaz, Hosseini, Leila, Høilund-Carlsen, Poul Flemming, Salehinasab, Raheleh, Rajabi, Mojgan, Badalzadeh, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animal models Animals Autophagy Biomedical and Life Sciences Biomedicine Biosynthesis Cell death Geriatrics Heart Ischemia Male Melatonin Melatonin - pharmacology Melatonin - therapeutic use MicroRNAs MicroRNAs - genetics miRNA Mitochondria Myocardial ischemia Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - prevention & control Neurosciences Nicotinamide Nicotinamide Mononucleotide - pharmacology Nicotinamide Mononucleotide - therapeutic use Organelle Biogenesis Pharmacology/Toxicology Proteins Rats Rats, Wistar Reperfusion Reperfusion Injury SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism
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