Cotransfer of resistance to cephalosporins, colistin, and fosfomycin mediated by an IncHI2/pSH16G4928-like plasmid in ESBL-producing monophasic Salmonella Typhimurium strains of pig origin
To assess the co-transmission risk of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin in Salmonella strains collected along the whole pork production chain. From a total of 107 Salmonella isolates from samples collected in pig slaughterhouses and markets, 15 ESBL-produc...
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| Veröffentlicht in: | Journal of applied microbiology 2023-03, Vol.134 (3) |
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| creator | Tan, Wei Lu, Yangchao Zhu, Zhihao Xu, Zhen Zhang, Yifan Huang, Qi Meng, Xianrong Li, Shaowen |
| description | To assess the co-transmission risk of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin in Salmonella strains collected along the whole pork production chain.
From a total of 107 Salmonella isolates from samples collected in pig slaughterhouses and markets, 15 ESBL-producing Salmonella strains resistant to cefotaxime were identified by broth microdilution method and clavulanic acid inhibition test, including 14 monophasic Salmonella Typhimurium strains and one Salmonella Derby strain. Whole genome sequence analysis showed that nine monophasic S. Typhimurium strains coresistant to colistin and fosfomycin carried the resistance genes blaCTX-M-14, mcr-1, and fosA3. Conjugational transfer tests demonstrated that the phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin could cotransfer back and forth between Salmonella and Escherichia coli via an IncHI2/pSH16G4928-like plasmid.
This study reports the cotransmission of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin via an IncHI2/pSH16G4928-like plasmid in Salmonella strains of animal origin, giving an alarm for the prevention of the development and spread of bacterial multidrug resistance. |
| doi_str_mv | 10.1093/jambio/lxac060 |
| format | Article |
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From a total of 107 Salmonella isolates from samples collected in pig slaughterhouses and markets, 15 ESBL-producing Salmonella strains resistant to cefotaxime were identified by broth microdilution method and clavulanic acid inhibition test, including 14 monophasic Salmonella Typhimurium strains and one Salmonella Derby strain. Whole genome sequence analysis showed that nine monophasic S. Typhimurium strains coresistant to colistin and fosfomycin carried the resistance genes blaCTX-M-14, mcr-1, and fosA3. Conjugational transfer tests demonstrated that the phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin could cotransfer back and forth between Salmonella and Escherichia coli via an IncHI2/pSH16G4928-like plasmid.
This study reports the cotransmission of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin via an IncHI2/pSH16G4928-like plasmid in Salmonella strains of animal origin, giving an alarm for the prevention of the development and spread of bacterial multidrug resistance.</description><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1093/jambio/lxac060</identifier><identifier>PMID: 36808475</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Cephalosporins - pharmacology ; Colistin - pharmacology ; Escherichia coli ; Escherichia coli Proteins - genetics ; Fosfomycin - pharmacology ; Microbial Sensitivity Tests ; Plasmids ; Salmonella typhimurium - genetics ; Swine</subject><ispartof>Journal of applied microbiology, 2023-03, Vol.134 (3)</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Applied Microbiology International.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5267-9639</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36808475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Wei</creatorcontrib><creatorcontrib>Lu, Yangchao</creatorcontrib><creatorcontrib>Zhu, Zhihao</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Zhang, Yifan</creatorcontrib><creatorcontrib>Huang, Qi</creatorcontrib><creatorcontrib>Meng, Xianrong</creatorcontrib><creatorcontrib>Li, Shaowen</creatorcontrib><title>Cotransfer of resistance to cephalosporins, colistin, and fosfomycin mediated by an IncHI2/pSH16G4928-like plasmid in ESBL-producing monophasic Salmonella Typhimurium strains of pig origin</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>To assess the co-transmission risk of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin in Salmonella strains collected along the whole pork production chain.
From a total of 107 Salmonella isolates from samples collected in pig slaughterhouses and markets, 15 ESBL-producing Salmonella strains resistant to cefotaxime were identified by broth microdilution method and clavulanic acid inhibition test, including 14 monophasic Salmonella Typhimurium strains and one Salmonella Derby strain. Whole genome sequence analysis showed that nine monophasic S. Typhimurium strains coresistant to colistin and fosfomycin carried the resistance genes blaCTX-M-14, mcr-1, and fosA3. Conjugational transfer tests demonstrated that the phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin could cotransfer back and forth between Salmonella and Escherichia coli via an IncHI2/pSH16G4928-like plasmid.
This study reports the cotransmission of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin via an IncHI2/pSH16G4928-like plasmid in Salmonella strains of animal origin, giving an alarm for the prevention of the development and spread of bacterial multidrug resistance.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Cephalosporins - pharmacology</subject><subject>Colistin - pharmacology</subject><subject>Escherichia coli</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Fosfomycin - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Plasmids</subject><subject>Salmonella typhimurium - genetics</subject><subject>Swine</subject><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMlOwzAQhi0kBGW5ckRz5NBQL3USH6ECWgmJQ3uvHMcuBi8hTiT6bjwcriiXWTT_P_NpELoh-J5gwWYf0jc2zty3VLjEJ2hCWMkLWlb0HF2k9IExYZiXZ-iclTWu5xWfoJ9FHHoZktE9RAO9TjYNMigNQwSlu3fpYupib0OagoouT22YggwtmJhM9HtlA3jdWjnoFpp9HsEqqOWKzrr1kpQvc0HrwtlPDZ2TydsWsuFp_fhadH1sx2zfgY8h5lPJKlhLlzvtnITNvnu3fuzt6CFlysxwYOzsDjLQzoYrdGqkS_r6mC_R5vlps1gWr28vq8VDvkAJGYoK87YmgtdCVIRQJnLdCKw5IyWV2hA1b1VFmTYGc8prpbkWTY4Ut4Yxdonu_tZm4K9Rp2HrbVIHxKDjmLa0qmpRMY5plt4epWOTn7Lteutlv9_-P5z9AkGShHc</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Tan, Wei</creator><creator>Lu, Yangchao</creator><creator>Zhu, Zhihao</creator><creator>Xu, Zhen</creator><creator>Zhang, Yifan</creator><creator>Huang, Qi</creator><creator>Meng, Xianrong</creator><creator>Li, Shaowen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5267-9639</orcidid></search><sort><creationdate>20230301</creationdate><title>Cotransfer of resistance to cephalosporins, colistin, and fosfomycin mediated by an IncHI2/pSH16G4928-like plasmid in ESBL-producing monophasic Salmonella Typhimurium strains of pig origin</title><author>Tan, Wei ; Lu, Yangchao ; Zhu, Zhihao ; Xu, Zhen ; Zhang, Yifan ; Huang, Qi ; Meng, Xianrong ; Li, Shaowen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-705d8195899711239195b90e53162aef1c4dc723eff05258ce5e9bce520df333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Cephalosporins - pharmacology</topic><topic>Colistin - pharmacology</topic><topic>Escherichia coli</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Fosfomycin - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Plasmids</topic><topic>Salmonella typhimurium - genetics</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Wei</creatorcontrib><creatorcontrib>Lu, Yangchao</creatorcontrib><creatorcontrib>Zhu, Zhihao</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Zhang, Yifan</creatorcontrib><creatorcontrib>Huang, Qi</creatorcontrib><creatorcontrib>Meng, Xianrong</creatorcontrib><creatorcontrib>Li, Shaowen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Wei</au><au>Lu, Yangchao</au><au>Zhu, Zhihao</au><au>Xu, Zhen</au><au>Zhang, Yifan</au><au>Huang, Qi</au><au>Meng, Xianrong</au><au>Li, Shaowen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cotransfer of resistance to cephalosporins, colistin, and fosfomycin mediated by an IncHI2/pSH16G4928-like plasmid in ESBL-producing monophasic Salmonella Typhimurium strains of pig origin</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>134</volume><issue>3</issue><eissn>1365-2672</eissn><abstract>To assess the co-transmission risk of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin in Salmonella strains collected along the whole pork production chain.
From a total of 107 Salmonella isolates from samples collected in pig slaughterhouses and markets, 15 ESBL-producing Salmonella strains resistant to cefotaxime were identified by broth microdilution method and clavulanic acid inhibition test, including 14 monophasic Salmonella Typhimurium strains and one Salmonella Derby strain. Whole genome sequence analysis showed that nine monophasic S. Typhimurium strains coresistant to colistin and fosfomycin carried the resistance genes blaCTX-M-14, mcr-1, and fosA3. Conjugational transfer tests demonstrated that the phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin could cotransfer back and forth between Salmonella and Escherichia coli via an IncHI2/pSH16G4928-like plasmid.
This study reports the cotransmission of phenotypic and genetic resistance to cephalosporins, colistin, and fosfomycin via an IncHI2/pSH16G4928-like plasmid in Salmonella strains of animal origin, giving an alarm for the prevention of the development and spread of bacterial multidrug resistance.</abstract><cop>England</cop><pmid>36808475</pmid><doi>10.1093/jambio/lxac060</doi><orcidid>https://orcid.org/0000-0002-5267-9639</orcidid></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Anti-Bacterial Agents - pharmacology Cephalosporins - pharmacology Colistin - pharmacology Escherichia coli Escherichia coli Proteins - genetics Fosfomycin - pharmacology Microbial Sensitivity Tests Plasmids Salmonella typhimurium - genetics Swine |
| title | Cotransfer of resistance to cephalosporins, colistin, and fosfomycin mediated by an IncHI2/pSH16G4928-like plasmid in ESBL-producing monophasic Salmonella Typhimurium strains of pig origin |
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