Mitochondria-associated ER stress evokes immunogenic cell death through the ROS-PERK-eIF2α pathway under PTT/CDT combined therapy

Chemodynamic therapy (CDT) can effectively induce immunogenic cell death (ICD) in tumours and is thus a promising strategy for boosting the efficacy of immunotherapy. However, the mechanism by which CDT enhances ICD and lowers ICD efficiency is unknown and this restricts its clinical application. In...

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Veröffentlicht in:	Acta biomaterialia 2023-04, Vol.160, p.211-224
Hauptverfasser:	Feng, Xiaoli, Lin, Tian, Chen, Dong, Li, Zhiyang, Yang, Qiuping, Tian, Huiting, Xiao, Yao, Lin, Mingzhen, Liang, Min, Guo, Weihong, Zhao, Peng, Guo, Zhaoze
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chemodynamic therapy eIF-2 Kinase - metabolism Endoplasmic Reticulum Stress Eukaryotic Initiation Factor-2 - metabolism Humans Hydrogen Peroxide - pharmacology Immunogenic Cell Death Immunotherapy Mitochondria damage Nanoparticles Neoplasms PERK Reactive Oxygen Species ROS
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