A timeline of tumour-associated macrophage biology
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the most abundant. Clinical correlative data and a plethora of preclinical studies in mouse models of cancers have shown that tumour-associated macrophage...
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| Veröffentlicht in: | Nature reviews. Cancer 2023-04, Vol.23 (4), p.238-257 |
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| container_title | Nature reviews. Cancer |
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| creator | Cassetta, Luca Pollard, Jeffrey W. |
| description | Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the most abundant. Clinical correlative data and a plethora of preclinical studies in mouse models of cancers have shown that tumour-associated macrophages (TAMs) play a cancer-promoting role. Within the primary tumour, TAMs promote tumour cell invasion and intravasation and tumour stem cell viability and induce angiogenesis. At the metastatic site, metastasis-associated macrophages promote extravasation, tumour cell survival and persistent growth, as well as maintain tumour cell dormancy in some contexts. In both the primary and metastatic sites, TAMs are suppressive to the activities of cytotoxic T and natural killer cells that have the potential to eradicate tumours. Such activities suggest that TAMs will be a major target for therapeutic intervention. In this Perspective article, we chronologically explore the evolution of our understanding of TAM biology put into the context of major enabling advances in macrophage biology.
Clinical correlative data and a plethora of preclinical studies of cancers have shown that both tumour-associated and metastasis-associated macrophages play an important role in promoting cancer. In this Perspective article, Cassetta and Pollard chronologically explore the evolution of our understanding of tumour-associated macrophage biology and enabling technologies. |
| doi_str_mv | 10.1038/s41568-022-00547-1 |
| format | Article |
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Pollard, Jeffrey W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-a2b609b179e968f54417d3765279ea43fca8f9c525662857bc5cf194a75fad493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>631/250/580/1884</topic><topic>631/67/327</topic><topic>Angiogenesis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antineoplastic Agents</topic><topic>Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell survival</topic><topic>Cell viability</topic><topic>Cytotoxicity</topic><topic>Dormancy</topic><topic>Extravasation</topic><topic>Humans</topic><topic>Macrophages</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Microenvironments</topic><topic>Natural killer cells</topic><topic>Neoplasms - pathology</topic><topic>Perspective</topic><topic>Tumor Microenvironment</topic><topic>Tumor-Associated Macrophages - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cassetta, Luca</creatorcontrib><creatorcontrib>Pollard, Jeffrey W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cassetta, Luca</au><au>Pollard, Jeffrey W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A timeline of tumour-associated macrophage biology</atitle><jtitle>Nature reviews. Cancer</jtitle><stitle>Nat Rev Cancer</stitle><addtitle>Nat Rev Cancer</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>23</volume><issue>4</issue><spage>238</spage><epage>257</epage><pages>238-257</pages><issn>1474-175X</issn><eissn>1474-1768</eissn><abstract>Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the most abundant. Clinical correlative data and a plethora of preclinical studies in mouse models of cancers have shown that tumour-associated macrophages (TAMs) play a cancer-promoting role. 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| ispartof | Nature reviews. Cancer, 2023-04, Vol.23 (4), p.238-257 |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | 631/250/580/1884 631/67/327 Angiogenesis Animal models Animals Antineoplastic Agents Biology Biomedical and Life Sciences Biomedicine Cancer Research Cell survival Cell viability Cytotoxicity Dormancy Extravasation Humans Macrophages Metastases Metastasis Mice Microenvironments Natural killer cells Neoplasms - pathology Perspective Tumor Microenvironment Tumor-Associated Macrophages - pathology Tumors |
| title | A timeline of tumour-associated macrophage biology |
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