Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer
Background A multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)–T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who u...
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| Veröffentlicht in: | International journal of clinical oncology 2023-04, Vol.28 (4), p.512-520 |
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| creator | Kondo, Takahito Tsukahara, Kiyoaki Kawakita, Daisuke Yoshimoto, Seiichi Miura, Kouki Sugasawa, Masashi Chikamatsu, Kazuaki Matsuzuka, Takashi Oze, Isao Kitamura, Morimasa Murakami, Yoshiko Otozai, Shinji Shinozaki, Takeshi Ohba, Shinichi Araki, Koji Mizumachi, Takatsugu Sato, Dai Wakisaka, Naohiro Hirakawa, Hitoshi Hasegawa, Yasuhisa |
| description | Background
A multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)–T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who underwent SLNB based on a subgroup analysis of this trial.
Methods
We analyzed 418 sentinel lymph nodes (SLNs) from 132 patients who underwent SLNB. The metastatic SLNs were classified into three categories based on size-isolated tumor cells: |
| doi_str_mv | 10.1007/s10147-023-02305-1 |
| format | Article |
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A multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)–T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who underwent SLNB based on a subgroup analysis of this trial.
Methods
We analyzed 418 sentinel lymph nodes (SLNs) from 132 patients who underwent SLNB. The metastatic SLNs were classified into three categories based on size-isolated tumor cells: < 0.2 mm, micrometastasis: ≥ 0.2 mm and < 2 mm, and macrometastasis: ≥ 2 mm. Three groups were formed based on the number of metastatic SLNs: no metastasis, 1 metastatic node, and ≥ 2 metastatic nodes. The size and number of metastatic SLNs on survival were evaluated using Cox proportional hazard models.
Results
Patients with macrometastasis and ≥ 2 metastatic SLNs had worse overall survival (OS) and disease-free survival (DFS) after adjustment for potential confounders (HR for OS: macrometastasis, 4.85; 95% CI 1.34–17.60; ≥ 2 metastatic SLN, 3.63; 95% CI 1.02–12.89; HR for DFS: macrometastasis, 2.94; 95% CI 1.16–7.44; ≥ 2 metastatic SLN, 2.97; 95% CI 1.18–7.51).
Conclusions
In patients who underwent SLNB, a poorer prognosis was associated with macrometastasis or having ≥ 2 metastatic SLNs.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-023-02305-1</identifier><identifier>PMID: 36795281</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Biopsy ; Breast Neoplasms - pathology ; Cancer Research ; Cell size ; Disease-Free Survival ; Female ; Humans ; Lymph nodes ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis - pathology ; Lymphatic system ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neck Dissection ; Oncology ; Oral cancer ; Oral carcinoma ; Oral cavity ; Original Article ; Prognosis ; Sentinel Lymph Node - pathology ; Sentinel Lymph Node - surgery ; Sentinel Lymph Node Biopsy ; Squamous cell carcinoma ; Surgical Oncology ; Tumor cells</subject><ispartof>International journal of clinical oncology, 2023-04, Vol.28 (4), p.512-520</ispartof><rights>The Author(s) under exclusive licence to Japan Society of Clinical Oncology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-ad2dc5ade91e0bcfee8d96aff02e343b640b06d4242b243227728035a8630e933</citedby><cites>FETCH-LOGICAL-c443t-ad2dc5ade91e0bcfee8d96aff02e343b640b06d4242b243227728035a8630e933</cites><orcidid>0000-0002-4198-9615 ; 0000-0003-3794-2790 ; 0000-0001-9323-3003</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-023-02305-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-023-02305-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36795281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, Takahito</creatorcontrib><creatorcontrib>Tsukahara, Kiyoaki</creatorcontrib><creatorcontrib>Kawakita, Daisuke</creatorcontrib><creatorcontrib>Yoshimoto, Seiichi</creatorcontrib><creatorcontrib>Miura, Kouki</creatorcontrib><creatorcontrib>Sugasawa, Masashi</creatorcontrib><creatorcontrib>Chikamatsu, Kazuaki</creatorcontrib><creatorcontrib>Matsuzuka, Takashi</creatorcontrib><creatorcontrib>Oze, Isao</creatorcontrib><creatorcontrib>Kitamura, Morimasa</creatorcontrib><creatorcontrib>Murakami, Yoshiko</creatorcontrib><creatorcontrib>Otozai, Shinji</creatorcontrib><creatorcontrib>Shinozaki, Takeshi</creatorcontrib><creatorcontrib>Ohba, Shinichi</creatorcontrib><creatorcontrib>Araki, Koji</creatorcontrib><creatorcontrib>Mizumachi, Takatsugu</creatorcontrib><creatorcontrib>Sato, Dai</creatorcontrib><creatorcontrib>Wakisaka, Naohiro</creatorcontrib><creatorcontrib>Hirakawa, Hitoshi</creatorcontrib><creatorcontrib>Hasegawa, Yasuhisa</creatorcontrib><title>Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Background
A multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)–T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who underwent SLNB based on a subgroup analysis of this trial.
Methods
We analyzed 418 sentinel lymph nodes (SLNs) from 132 patients who underwent SLNB. The metastatic SLNs were classified into three categories based on size-isolated tumor cells: < 0.2 mm, micrometastasis: ≥ 0.2 mm and < 2 mm, and macrometastasis: ≥ 2 mm. Three groups were formed based on the number of metastatic SLNs: no metastasis, 1 metastatic node, and ≥ 2 metastatic nodes. The size and number of metastatic SLNs on survival were evaluated using Cox proportional hazard models.
Results
Patients with macrometastasis and ≥ 2 metastatic SLNs had worse overall survival (OS) and disease-free survival (DFS) after adjustment for potential confounders (HR for OS: macrometastasis, 4.85; 95% CI 1.34–17.60; ≥ 2 metastatic SLN, 3.63; 95% CI 1.02–12.89; HR for DFS: macrometastasis, 2.94; 95% CI 1.16–7.44; ≥ 2 metastatic SLN, 2.97; 95% CI 1.18–7.51).
Conclusions
In patients who underwent SLNB, a poorer prognosis was associated with macrometastasis or having ≥ 2 metastatic SLNs.</description><subject>Biopsy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Cell size</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neck Dissection</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>Oral cavity</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Sentinel Lymph Node - surgery</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Squamous cell carcinoma</subject><subject>Surgical Oncology</subject><subject>Tumor cells</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctu1TAQhi1ERS_wAiyQJTZsQseXxMkSVeUiFXVT1pZjT1pXjh3shOq8AM-NT08BiQWSLY_s7_89mp-Q1wzeMwB1XhgwqRrgYr-hbdgzcsKkUI1Sij-vtZCsGTreHpPTUu4BmOpa_oIci04NLe_ZCfn51dicik2Lt9RER-ctrH4JSGdcTakLC_WRFoyrjxho2M3LHY3JIR19WsqOmow0Y1nQrv4HhnpRSrLerOjog1_v6JJSpktOtzEV_-iGJlcuZROoNdFifkmOJhMKvno6z8i3j5c3F5-bq-tPXy4-XDVWSrE2xnFnW-NwYAijnRB7N3RmmoCjkGLsJIzQOcklH7kUnNc59CBa03cCcBDijLw7-NZ2vm9YVj37YjEEEzFtRVeBkiB7BhV9-w96n7Yca3ea9wNIEMCHSvEDtZ9iyTjpJfvZ5J1moPcp6UNKuiakH1PSrIrePFlv44zuj-R3LBUQB6DUp3iL-e_f_7H9BejTnz4</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Kondo, Takahito</creator><creator>Tsukahara, Kiyoaki</creator><creator>Kawakita, Daisuke</creator><creator>Yoshimoto, Seiichi</creator><creator>Miura, Kouki</creator><creator>Sugasawa, Masashi</creator><creator>Chikamatsu, Kazuaki</creator><creator>Matsuzuka, Takashi</creator><creator>Oze, Isao</creator><creator>Kitamura, Morimasa</creator><creator>Murakami, Yoshiko</creator><creator>Otozai, Shinji</creator><creator>Shinozaki, Takeshi</creator><creator>Ohba, Shinichi</creator><creator>Araki, Koji</creator><creator>Mizumachi, Takatsugu</creator><creator>Sato, Dai</creator><creator>Wakisaka, Naohiro</creator><creator>Hirakawa, Hitoshi</creator><creator>Hasegawa, Yasuhisa</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4198-9615</orcidid><orcidid>https://orcid.org/0000-0003-3794-2790</orcidid><orcidid>https://orcid.org/0000-0001-9323-3003</orcidid></search><sort><creationdate>20230401</creationdate><title>Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer</title><author>Kondo, Takahito ; Tsukahara, Kiyoaki ; Kawakita, Daisuke ; Yoshimoto, Seiichi ; Miura, Kouki ; Sugasawa, Masashi ; Chikamatsu, Kazuaki ; Matsuzuka, Takashi ; Oze, Isao ; Kitamura, Morimasa ; Murakami, Yoshiko ; Otozai, Shinji ; Shinozaki, Takeshi ; Ohba, Shinichi ; Araki, Koji ; Mizumachi, Takatsugu ; Sato, Dai ; Wakisaka, Naohiro ; Hirakawa, Hitoshi ; Hasegawa, Yasuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-ad2dc5ade91e0bcfee8d96aff02e343b640b06d4242b243227728035a8630e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Cell size</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neck Dissection</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>Oral carcinoma</topic><topic>Oral cavity</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Sentinel Lymph Node - pathology</topic><topic>Sentinel Lymph Node - surgery</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Squamous cell carcinoma</topic><topic>Surgical Oncology</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Takahito</creatorcontrib><creatorcontrib>Tsukahara, Kiyoaki</creatorcontrib><creatorcontrib>Kawakita, Daisuke</creatorcontrib><creatorcontrib>Yoshimoto, Seiichi</creatorcontrib><creatorcontrib>Miura, Kouki</creatorcontrib><creatorcontrib>Sugasawa, Masashi</creatorcontrib><creatorcontrib>Chikamatsu, Kazuaki</creatorcontrib><creatorcontrib>Matsuzuka, Takashi</creatorcontrib><creatorcontrib>Oze, Isao</creatorcontrib><creatorcontrib>Kitamura, Morimasa</creatorcontrib><creatorcontrib>Murakami, Yoshiko</creatorcontrib><creatorcontrib>Otozai, Shinji</creatorcontrib><creatorcontrib>Shinozaki, Takeshi</creatorcontrib><creatorcontrib>Ohba, Shinichi</creatorcontrib><creatorcontrib>Araki, Koji</creatorcontrib><creatorcontrib>Mizumachi, Takatsugu</creatorcontrib><creatorcontrib>Sato, Dai</creatorcontrib><creatorcontrib>Wakisaka, Naohiro</creatorcontrib><creatorcontrib>Hirakawa, Hitoshi</creatorcontrib><creatorcontrib>Hasegawa, Yasuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Takahito</au><au>Tsukahara, Kiyoaki</au><au>Kawakita, Daisuke</au><au>Yoshimoto, Seiichi</au><au>Miura, Kouki</au><au>Sugasawa, Masashi</au><au>Chikamatsu, Kazuaki</au><au>Matsuzuka, Takashi</au><au>Oze, Isao</au><au>Kitamura, Morimasa</au><au>Murakami, Yoshiko</au><au>Otozai, Shinji</au><au>Shinozaki, Takeshi</au><au>Ohba, Shinichi</au><au>Araki, Koji</au><au>Mizumachi, Takatsugu</au><au>Sato, Dai</au><au>Wakisaka, Naohiro</au><au>Hirakawa, Hitoshi</au><au>Hasegawa, Yasuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>28</volume><issue>4</issue><spage>512</spage><epage>520</epage><pages>512-520</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
A multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)–T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who underwent SLNB based on a subgroup analysis of this trial.
Methods
We analyzed 418 sentinel lymph nodes (SLNs) from 132 patients who underwent SLNB. The metastatic SLNs were classified into three categories based on size-isolated tumor cells: < 0.2 mm, micrometastasis: ≥ 0.2 mm and < 2 mm, and macrometastasis: ≥ 2 mm. Three groups were formed based on the number of metastatic SLNs: no metastasis, 1 metastatic node, and ≥ 2 metastatic nodes. The size and number of metastatic SLNs on survival were evaluated using Cox proportional hazard models.
Results
Patients with macrometastasis and ≥ 2 metastatic SLNs had worse overall survival (OS) and disease-free survival (DFS) after adjustment for potential confounders (HR for OS: macrometastasis, 4.85; 95% CI 1.34–17.60; ≥ 2 metastatic SLN, 3.63; 95% CI 1.02–12.89; HR for DFS: macrometastasis, 2.94; 95% CI 1.16–7.44; ≥ 2 metastatic SLN, 2.97; 95% CI 1.18–7.51).
Conclusions
In patients who underwent SLNB, a poorer prognosis was associated with macrometastasis or having ≥ 2 metastatic SLNs.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36795281</pmid><doi>10.1007/s10147-023-02305-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4198-9615</orcidid><orcidid>https://orcid.org/0000-0003-3794-2790</orcidid><orcidid>https://orcid.org/0000-0001-9323-3003</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of clinical oncology, 2023-04, Vol.28 (4), p.512-520 |
| issn | 1341-9625 1437-7772 |
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| subjects | Biopsy Breast Neoplasms - pathology Cancer Research Cell size Disease-Free Survival Female Humans Lymph nodes Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - pathology Lymphatic system Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neck Dissection Oncology Oral cancer Oral carcinoma Oral cavity Original Article Prognosis Sentinel Lymph Node - pathology Sentinel Lymph Node - surgery Sentinel Lymph Node Biopsy Squamous cell carcinoma Surgical Oncology Tumor cells |
| title | Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer |
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