Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways
Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several risk factors have been associated with TC radiation exposure, autoimmunity, and genetics. Microribonucleic acids (miR...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2023-03, Vol.243, p.154371-154371, Article 154371 |
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| creator | Doghish, Ahmed S. El-Mahdy, Hesham A. Ismail, Ahmed Hegazy, Maghawry Mokhtar, Mahmoud Mohamed Elkhawaga, Samy Y. Elkady, Mohamed A. Yehia, Amr Mohamed Elsakka, Elsayed G.E. |
| description | Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several risk factors have been associated with TC radiation exposure, autoimmunity, and genetics. Microribonucleic acids (miRNAs) are the most important genetic determinants of TC. They are small chains of nucleic acids that are able to inhibit the expression of several target genes. They could target several genes involved in TC proliferation, angiogenesis, apoptosis, development, and even resistance to therapy. Besides, they could influence the stemness of TC. Moreover, they could regulate several signaling pathways such as WNT/β-catenin, PI3K/AKT/mTOR axis, JAK/STAT, TGF- β, EGFR, and P53. Besides signaling pathways, miRNAs are also involved in the resistance of TC to major treatments such as surgery, thyroid hormone-inhibiting therapy, radioactive iodine, and adjuvant radiation. The stability and sensitivity of several miRNAs might be exploited as an approach for the usage of miRNAs as diagnostic and/or prognostic tools in TC. |
| doi_str_mv | 10.1016/j.prp.2023.154371 |
| format | Article |
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It has many types, the Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several risk factors have been associated with TC radiation exposure, autoimmunity, and genetics. Microribonucleic acids (miRNAs) are the most important genetic determinants of TC. They are small chains of nucleic acids that are able to inhibit the expression of several target genes. They could target several genes involved in TC proliferation, angiogenesis, apoptosis, development, and even resistance to therapy. Besides, they could influence the stemness of TC. Moreover, they could regulate several signaling pathways such as WNT/β-catenin, PI3K/AKT/mTOR axis, JAK/STAT, TGF- β, EGFR, and P53. Besides signaling pathways, miRNAs are also involved in the resistance of TC to major treatments such as surgery, thyroid hormone-inhibiting therapy, radioactive iodine, and adjuvant radiation. The stability and sensitivity of several miRNAs might be exploited as an approach for the usage of miRNAs as diagnostic and/or prognostic tools in TC.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2023.154371</identifier><identifier>PMID: 36791561</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Carcinoma, Papillary - genetics ; Cell Line, Tumor ; Drug resistance ; Humans ; Iodine Radioisotopes ; MicroRNAs - genetics ; MicroRNAs - metabolism ; MiRNA ; Neoplastic Processes ; Oncogenic miRNA ; Pathogenesis ; Phosphatidylinositol 3-Kinases - metabolism ; Signal Transduction ; Thyroid cancer (TC) ; Thyroid Neoplasms - pathology ; Tumor suppressor miRNA</subject><ispartof>Pathology, research and practice, 2023-03, Vol.243, p.154371-154371, Article 154371</ispartof><rights>2023 Elsevier GmbH</rights><rights>Copyright © 2023 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-bbd3de132c156df05dba7aab22704161301593f83cd3a2c2c49a23b98789e1033</citedby><cites>FETCH-LOGICAL-c353t-bbd3de132c156df05dba7aab22704161301593f83cd3a2c2c49a23b98789e1033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2023.154371$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36791561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doghish, Ahmed S.</creatorcontrib><creatorcontrib>El-Mahdy, Hesham A.</creatorcontrib><creatorcontrib>Ismail, Ahmed</creatorcontrib><creatorcontrib>Hegazy, Maghawry</creatorcontrib><creatorcontrib>Mokhtar, Mahmoud Mohamed</creatorcontrib><creatorcontrib>Elkhawaga, Samy Y.</creatorcontrib><creatorcontrib>Elkady, Mohamed A.</creatorcontrib><creatorcontrib>Yehia, Amr Mohamed</creatorcontrib><creatorcontrib>Elsakka, Elsayed G.E.</creatorcontrib><title>Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several risk factors have been associated with TC radiation exposure, autoimmunity, and genetics. Microribonucleic acids (miRNAs) are the most important genetic determinants of TC. They are small chains of nucleic acids that are able to inhibit the expression of several target genes. They could target several genes involved in TC proliferation, angiogenesis, apoptosis, development, and even resistance to therapy. Besides, they could influence the stemness of TC. Moreover, they could regulate several signaling pathways such as WNT/β-catenin, PI3K/AKT/mTOR axis, JAK/STAT, TGF- β, EGFR, and P53. Besides signaling pathways, miRNAs are also involved in the resistance of TC to major treatments such as surgery, thyroid hormone-inhibiting therapy, radioactive iodine, and adjuvant radiation. The stability and sensitivity of several miRNAs might be exploited as an approach for the usage of miRNAs as diagnostic and/or prognostic tools in TC.</description><subject>Carcinoma, Papillary - genetics</subject><subject>Cell Line, Tumor</subject><subject>Drug resistance</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>MiRNA</subject><subject>Neoplastic Processes</subject><subject>Oncogenic miRNA</subject><subject>Pathogenesis</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Signal Transduction</subject><subject>Thyroid cancer (TC)</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tumor suppressor miRNA</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu2zAQJIoGjZv0A3opeOxFDh96IqcgSNMAQQOkzZlYkSubriSqJF3Df5NPDWUnPfZAkNidmeXsEPKZsyVnvLzYLCc_LQUTcsmLXFb8HVnwktcZKyV_TxZM5nnGpKxPyccQNoyxiuX8AzmVZdXwouQL8vzTrkbbWQ2jRuo6OtjHH1eBupHGNaaz984aemh7Onm38hiCTW0YDU1vG-KBGh2NHiEOOEa6s3FNw4TaQk8hxlSbKTMmiXrXH0Zp70LIIvS_aYtxhzjSkH4DvR1XdIK43sE-nJOTDvqAn17vM_L07ebX9ffs_uH27vrqPtOykDFrWyMNcil08mU6VpgWKoBWiNlyySXjRSO7WmojQWih8waEbJu6qhvkaUdn5OtRN3n8s8UQ1WCDxr6HEd02KFFVVc5EzliC8iP0YMBjpyZvB_B7xZmag1GbVJnUHIw6BpM4X17lt-2A5h_jLYkEuDwCMJn8a9GroC2mzRrrUUdlnP2P_As0laFs</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Doghish, Ahmed S.</creator><creator>El-Mahdy, Hesham A.</creator><creator>Ismail, Ahmed</creator><creator>Hegazy, Maghawry</creator><creator>Mokhtar, Mahmoud Mohamed</creator><creator>Elkhawaga, Samy Y.</creator><creator>Elkady, Mohamed A.</creator><creator>Yehia, Amr Mohamed</creator><creator>Elsakka, Elsayed G.E.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways</title><author>Doghish, Ahmed S. ; El-Mahdy, Hesham A. ; Ismail, Ahmed ; Hegazy, Maghawry ; Mokhtar, Mahmoud Mohamed ; Elkhawaga, Samy Y. ; Elkady, Mohamed A. ; Yehia, Amr Mohamed ; Elsakka, Elsayed G.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-bbd3de132c156df05dba7aab22704161301593f83cd3a2c2c49a23b98789e1033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Papillary - genetics</topic><topic>Cell Line, Tumor</topic><topic>Drug resistance</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>MiRNA</topic><topic>Neoplastic Processes</topic><topic>Oncogenic miRNA</topic><topic>Pathogenesis</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Signal Transduction</topic><topic>Thyroid cancer (TC)</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tumor suppressor miRNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doghish, Ahmed S.</creatorcontrib><creatorcontrib>El-Mahdy, Hesham A.</creatorcontrib><creatorcontrib>Ismail, Ahmed</creatorcontrib><creatorcontrib>Hegazy, Maghawry</creatorcontrib><creatorcontrib>Mokhtar, Mahmoud Mohamed</creatorcontrib><creatorcontrib>Elkhawaga, Samy Y.</creatorcontrib><creatorcontrib>Elkady, Mohamed A.</creatorcontrib><creatorcontrib>Yehia, Amr Mohamed</creatorcontrib><creatorcontrib>Elsakka, Elsayed G.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doghish, Ahmed S.</au><au>El-Mahdy, Hesham A.</au><au>Ismail, Ahmed</au><au>Hegazy, Maghawry</au><au>Mokhtar, Mahmoud Mohamed</au><au>Elkhawaga, Samy Y.</au><au>Elkady, Mohamed A.</au><au>Yehia, Amr Mohamed</au><au>Elsakka, Elsayed G.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2023-03</date><risdate>2023</risdate><volume>243</volume><spage>154371</spage><epage>154371</epage><pages>154371-154371</pages><artnum>154371</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several risk factors have been associated with TC radiation exposure, autoimmunity, and genetics. Microribonucleic acids (miRNAs) are the most important genetic determinants of TC. They are small chains of nucleic acids that are able to inhibit the expression of several target genes. They could target several genes involved in TC proliferation, angiogenesis, apoptosis, development, and even resistance to therapy. Besides, they could influence the stemness of TC. Moreover, they could regulate several signaling pathways such as WNT/β-catenin, PI3K/AKT/mTOR axis, JAK/STAT, TGF- β, EGFR, and P53. Besides signaling pathways, miRNAs are also involved in the resistance of TC to major treatments such as surgery, thyroid hormone-inhibiting therapy, radioactive iodine, and adjuvant radiation. 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| subjects | Carcinoma, Papillary - genetics Cell Line, Tumor Drug resistance Humans Iodine Radioisotopes MicroRNAs - genetics MicroRNAs - metabolism MiRNA Neoplastic Processes Oncogenic miRNA Pathogenesis Phosphatidylinositol 3-Kinases - metabolism Signal Transduction Thyroid cancer (TC) Thyroid Neoplasms - pathology Tumor suppressor miRNA |
| title | Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways |
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