Effect of evodiamine on cell death pathways in human gastric cancer cells
Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyc...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2022-11, Vol.35 (6), p.1523-1529 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Zhang, Hanni Liu, Liping Li, Pingxiang Guo, Yunliang Ge, Keli |
| description | Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells. |
| doi_str_mv | 10.36721/PJPS.2022.35.6.REG.1523-1529.1 |
| format | Article |
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BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2022.35.6.REG.1523-1529.1</identifier><identifier>PMID: 36789811</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Alkaloids ; Apoptosis ; Care and treatment ; Cell death ; Cell Line, Tumor ; Chemical properties ; G2 Phase Cell Cycle Checkpoints ; Health aspects ; Humans ; Medicine, Chinese ; Physiological aspects ; Reactive Oxygen Species ; Stomach cancer ; Stomach Neoplasms - drug therapy</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2022-11, Vol.35 (6), p.1523-1529</ispartof><rights>COPYRIGHT 2022 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36789811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hanni</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Li, Pingxiang</creatorcontrib><creatorcontrib>Guo, Yunliang</creatorcontrib><creatorcontrib>Ge, Keli</creatorcontrib><title>Effect of evodiamine on cell death pathways in human gastric cancer cells</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.</description><subject>Alkaloids</subject><subject>Apoptosis</subject><subject>Care and treatment</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Chemical properties</subject><subject>G2 Phase Cell Cycle Checkpoints</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Medicine, Chinese</subject><subject>Physiological aspects</subject><subject>Reactive Oxygen Species</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - drug therapy</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLw0AUhWeh2Fr9CzLgQjeJ88oksyyl1krB4gPchcnMnXakSWomUfrvTa0uBLlwLly-czkchK4oiblMGb1Z3i-fYkYYi3kSy_hxOotpwnjUi4rpERpSQmkkCX0doNMQ3giRQil1gga9P1MZpUM0nzoHpsW1w_BRW69LXwGuK2xgs8EWdLvG214-9S5gX-F1V-oKr3RoG2-w0ZWB5psNZ-jY6U2A8589Qi-30-fJXbR4mM0n40W0YmnWRkwVmVDSau44I0IVoJkgTCbcqEIVglotqQOqVFIAAOHWGctFIriwqSKEj9D14e-2qd87CG1e-rBPoCuou5CzNE0JZTSRPXp5QFd6A7mvXN022uzxfJxyIpmQKe2p-B-qHwulN3UFzvf3P4aLnwRdUYLNt40vdbPLf1vlXzd9eIg</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Zhang, Hanni</creator><creator>Liu, Liping</creator><creator>Li, Pingxiang</creator><creator>Guo, Yunliang</creator><creator>Ge, Keli</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202211</creationdate><title>Effect of evodiamine on cell death pathways in human gastric cancer cells</title><author>Zhang, Hanni ; Liu, Liping ; Li, Pingxiang ; Guo, Yunliang ; Ge, Keli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-29b8496da3f32049bea2402653c9b9b41da61fe1995beee03dfcd345434d79003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alkaloids</topic><topic>Apoptosis</topic><topic>Care and treatment</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Chemical properties</topic><topic>G2 Phase Cell Cycle Checkpoints</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Medicine, Chinese</topic><topic>Physiological aspects</topic><topic>Reactive Oxygen Species</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hanni</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Li, Pingxiang</creatorcontrib><creatorcontrib>Guo, Yunliang</creatorcontrib><creatorcontrib>Ge, Keli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hanni</au><au>Liu, Liping</au><au>Li, Pingxiang</au><au>Guo, Yunliang</au><au>Ge, Keli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of evodiamine on cell death pathways in human gastric cancer cells</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2022-11</date><risdate>2022</risdate><volume>35</volume><issue>6</issue><spage>1523</spage><epage>1529</epage><pages>1523-1529</pages><issn>1011-601X</issn><abstract>Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>36789811</pmid><doi>10.36721/PJPS.2022.35.6.REG.1523-1529.1</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alkaloids Apoptosis Care and treatment Cell death Cell Line, Tumor Chemical properties G2 Phase Cell Cycle Checkpoints Health aspects Humans Medicine, Chinese Physiological aspects Reactive Oxygen Species Stomach cancer Stomach Neoplasms - drug therapy |
| title | Effect of evodiamine on cell death pathways in human gastric cancer cells |
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