Dissolution enhancement of olmesartan medoxomil through polymer-based surface solid dispersion and solidified surfactant techniques
This study aims to formulate Olmesartan medoxomil (OM) into oral fast-dissolving tablets (FDTs) to improve its solubility and bioavailability via two different techniques; The polymer-based surface solid dispersion (SSD) technique and the solidified surfactant (SS) technique. In the first technique,...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2022-11, Vol.35 (6), p.1481-1493 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Daihom, Baher A Elbortokaly, Heba M Mohamed, Magdy I Al-Mahallawi, Abdulaziz M |
| description | This study aims to formulate Olmesartan medoxomil (OM) into oral fast-dissolving tablets (FDTs) to improve its solubility and bioavailability via two different techniques; The polymer-based surface solid dispersion (SSD) technique and the solidified surfactant (SS) technique. In the first technique, two polymers were used; polyvinylpyrrolidone (PVP K90) and Poloxamer 407 (Pluronic®F127), while in the second technique the liquid Tween 80 was solidified by adsorption onto Aeroperl®300. The pre-compression and post-compression parameters of the obtained formulations were assessed. The best formulations were subjected to a taste masking evaluation and a short-term stability study. The results demonstrated that, in comparison to the pure drug, the proportion of drug released from each of the prepared FDTs considerably increased. Results of the stability studies showed that the chosen drug formulations remained stable throughout the storage period. |
| doi_str_mv | 10.36721/PJPS.2022.35.6.REG.1481-1493.1 |
| format | Article |
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In the first technique, two polymers were used; polyvinylpyrrolidone (PVP K90) and Poloxamer 407 (Pluronic®F127), while in the second technique the liquid Tween 80 was solidified by adsorption onto Aeroperl®300. The pre-compression and post-compression parameters of the obtained formulations were assessed. The best formulations were subjected to a taste masking evaluation and a short-term stability study. The results demonstrated that, in comparison to the pure drug, the proportion of drug released from each of the prepared FDTs considerably increased. Results of the stability studies showed that the chosen drug formulations remained stable throughout the storage period.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2022.35.6.REG.1481-1493.1</identifier><identifier>PMID: 36789807</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Biological Availability ; Chemical properties ; Chemical research ; Dissolution (Chemistry) ; Drug delivery systems ; Drugs ; Materials ; Olmesartan Medoxomil ; Pharmaceutical chemistry ; Poloxamer ; Polymers ; Pulmonary Surfactants ; Solubility ; Surface-Active Agents ; Tablets ; Vehicles</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2022-11, Vol.35 (6), p.1481-1493</ispartof><rights>COPYRIGHT 2022 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36789807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daihom, Baher A</creatorcontrib><creatorcontrib>Elbortokaly, Heba M</creatorcontrib><creatorcontrib>Mohamed, Magdy I</creatorcontrib><creatorcontrib>Al-Mahallawi, Abdulaziz M</creatorcontrib><title>Dissolution enhancement of olmesartan medoxomil through polymer-based surface solid dispersion and solidified surfactant techniques</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>This study aims to formulate Olmesartan medoxomil (OM) into oral fast-dissolving tablets (FDTs) to improve its solubility and bioavailability via two different techniques; The polymer-based surface solid dispersion (SSD) technique and the solidified surfactant (SS) technique. In the first technique, two polymers were used; polyvinylpyrrolidone (PVP K90) and Poloxamer 407 (Pluronic®F127), while in the second technique the liquid Tween 80 was solidified by adsorption onto Aeroperl®300. The pre-compression and post-compression parameters of the obtained formulations were assessed. The best formulations were subjected to a taste masking evaluation and a short-term stability study. The results demonstrated that, in comparison to the pure drug, the proportion of drug released from each of the prepared FDTs considerably increased. 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In the first technique, two polymers were used; polyvinylpyrrolidone (PVP K90) and Poloxamer 407 (Pluronic®F127), while in the second technique the liquid Tween 80 was solidified by adsorption onto Aeroperl®300. The pre-compression and post-compression parameters of the obtained formulations were assessed. The best formulations were subjected to a taste masking evaluation and a short-term stability study. The results demonstrated that, in comparison to the pure drug, the proportion of drug released from each of the prepared FDTs considerably increased. Results of the stability studies showed that the chosen drug formulations remained stable throughout the storage period.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>36789807</pmid><doi>10.36721/PJPS.2022.35.6.REG.1481-1493.1</doi><tpages>13</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological Availability Chemical properties Chemical research Dissolution (Chemistry) Drug delivery systems Drugs Materials Olmesartan Medoxomil Pharmaceutical chemistry Poloxamer Polymers Pulmonary Surfactants Solubility Surface-Active Agents Tablets Vehicles |
| title | Dissolution enhancement of olmesartan medoxomil through polymer-based surface solid dispersion and solidified surfactant techniques |
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