A Lower Frequency of Spliceosome Mutations Distinguishes Clonal Cytopenias of Undetermined Significance From Low-Risk Myelodysplastic Syndromes, Despite Inherent Similarities in Genomic, Laboratory, and Clinical Features

Clonal cytopenias of undetermined significance (CCUS) are associated with an increased risk of developing a myelodysplastic syndrome (MDS); however, the mechanism and factors associated with evolution remain unclear. We propose that next-generation sequencing (NGS) of cytopenic cases with equivocal...

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Veröffentlicht in:	Modern pathology 2023-03, Vol.36 (3), p.100068-100068, Article 100068
Hauptverfasser:	Ferrone, Christina K., McNaughton, Amy J.M., Rashedi, Iran, Ring, Brooke, Buckstein, Rena, Tsui, Hubert, Rauh, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	CCUS Genomics Humans MDS Mutation Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - genetics Neoplasms next-generation sequencing Spliceosomes
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