Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action
Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide s...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2022-11, Vol.35 (6), p.1581-1694 |
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| creator | Oyagbemi, Ademola Adetokunbo Hassan, Fasilat Oluwakemi Ajibade, Temitayo Olabisi Ola-Davies, Olufunke Eunice Omobowale, Temidayo Olutayo Ajani, Olumide Samuel Jarikre, Theophilus Aghogho Soetan, Kehinde Olugboyega Saba, Adebowale Benard Adedapo, Adeolu Alex Obemisola Aro, Abimbola Olugbenga Oyeyemi, Matthew Obukowho Emikpe, Benjamin Nkadimeng, Sanah Malomile Joy McGaw, Lyndy Kayoka-Kabongo, Prudence Ngalula Audu Yakubu, Momoh Oguntibeju, Oluwafemi Omoniyi |
| description | Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability. |
| doi_str_mv | 10.36721/PJPS.2022.35.6.REG.1581-1594.1 |
| format | Article |
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High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2022.35.6.REG.1581-1594.1</identifier><identifier>PMID: 36789818</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Antihypertensive Agents - pharmacology ; Antioxidants - pharmacology ; Asteraceae ; Blood Pressure ; Care and treatment ; Chemical properties ; Development and progression ; Health aspects ; Hypertension ; Hypertension - drug therapy ; Hypertension - metabolism ; Male ; Materia medica, Vegetable ; Medicinal plants ; NG-Nitroarginine Methyl Ester ; Nitric Oxide - metabolism ; Oxidative Stress ; Physiological aspects ; Plant extracts ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Sodium</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2022-11, Vol.35 (6), p.1581-1694</ispartof><rights>COPYRIGHT 2022 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36789818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oyagbemi, Ademola Adetokunbo</creatorcontrib><creatorcontrib>Hassan, Fasilat Oluwakemi</creatorcontrib><creatorcontrib>Ajibade, Temitayo Olabisi</creatorcontrib><creatorcontrib>Ola-Davies, Olufunke Eunice</creatorcontrib><creatorcontrib>Omobowale, Temidayo Olutayo</creatorcontrib><creatorcontrib>Ajani, Olumide Samuel</creatorcontrib><creatorcontrib>Jarikre, Theophilus Aghogho</creatorcontrib><creatorcontrib>Soetan, Kehinde Olugboyega</creatorcontrib><creatorcontrib>Saba, Adebowale Benard</creatorcontrib><creatorcontrib>Adedapo, Adeolu Alex</creatorcontrib><creatorcontrib>Obemisola Aro, Abimbola</creatorcontrib><creatorcontrib>Olugbenga Oyeyemi, Matthew</creatorcontrib><creatorcontrib>Obukowho Emikpe, Benjamin</creatorcontrib><creatorcontrib>Nkadimeng, Sanah Malomile</creatorcontrib><creatorcontrib>Joy McGaw, Lyndy</creatorcontrib><creatorcontrib>Kayoka-Kabongo, Prudence Ngalula</creatorcontrib><creatorcontrib>Audu Yakubu, Momoh</creatorcontrib><creatorcontrib>Oguntibeju, Oluwafemi Omoniyi</creatorcontrib><title>Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.</description><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Asteraceae</subject><subject>Blood Pressure</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - metabolism</subject><subject>Male</subject><subject>Materia medica, Vegetable</subject><subject>Medicinal plants</subject><subject>NG-Nitroarginine Methyl Ester</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidative Stress</subject><subject>Physiological aspects</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAURj2AaCn8BWSJAZYEXye2k7GqSgFVouIltugmdlqjPErsIPrvSdUy3eGe8w2HkBtgYSQVh7vV0-o15IzzMBKhDF_mixBEAgGINA7hhIyBAQSSweeInDv3xZiM0zQ9I6PBT9IEkjH5mDbebnZb03nTOPtjKBbetg1tS7rEvkGD1GOHv1jYsq0sUmw0td7Ruq1M0VfY0doUG2ysq_fSQb8gpyVWzlwe74S838_fZg_B8nnxOJsugzWPUh_oEhCUzpWEnIGEFFUkdS6VzBU3IAUT2gw_1CALwfNSA6QszhNR5iLiJpqQ28Putmu_e-N8VltXmKrCxrS9y7hSaojAEhjQ6wO6xspktilb32Gxx7Opipjk8RBloK6Og31eG51tO1tjt8v-i0V_AXdupw</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Oyagbemi, Ademola Adetokunbo</creator><creator>Hassan, Fasilat Oluwakemi</creator><creator>Ajibade, Temitayo Olabisi</creator><creator>Ola-Davies, Olufunke Eunice</creator><creator>Omobowale, Temidayo Olutayo</creator><creator>Ajani, Olumide Samuel</creator><creator>Jarikre, Theophilus Aghogho</creator><creator>Soetan, Kehinde Olugboyega</creator><creator>Saba, Adebowale Benard</creator><creator>Adedapo, Adeolu Alex</creator><creator>Obemisola Aro, Abimbola</creator><creator>Olugbenga Oyeyemi, Matthew</creator><creator>Obukowho Emikpe, Benjamin</creator><creator>Nkadimeng, Sanah Malomile</creator><creator>Joy McGaw, Lyndy</creator><creator>Kayoka-Kabongo, Prudence Ngalula</creator><creator>Audu Yakubu, Momoh</creator><creator>Oguntibeju, Oluwafemi Omoniyi</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202211</creationdate><title>Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action</title><author>Oyagbemi, Ademola Adetokunbo ; Hassan, Fasilat Oluwakemi ; Ajibade, Temitayo Olabisi ; Ola-Davies, Olufunke Eunice ; Omobowale, Temidayo Olutayo ; Ajani, Olumide Samuel ; Jarikre, Theophilus Aghogho ; Soetan, Kehinde Olugboyega ; Saba, Adebowale Benard ; Adedapo, Adeolu Alex ; Obemisola Aro, Abimbola ; Olugbenga Oyeyemi, Matthew ; Obukowho Emikpe, Benjamin ; Nkadimeng, Sanah Malomile ; Joy McGaw, Lyndy ; Kayoka-Kabongo, Prudence Ngalula ; Audu Yakubu, Momoh ; Oguntibeju, Oluwafemi Omoniyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g239t-df1a17db761b01619a736db676b72e16505de61bad16c52bfd11904b85fb532e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Asteraceae</topic><topic>Blood Pressure</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - metabolism</topic><topic>Male</topic><topic>Materia medica, Vegetable</topic><topic>Medicinal plants</topic><topic>NG-Nitroarginine Methyl Ester</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidative Stress</topic><topic>Physiological aspects</topic><topic>Plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oyagbemi, Ademola Adetokunbo</creatorcontrib><creatorcontrib>Hassan, Fasilat Oluwakemi</creatorcontrib><creatorcontrib>Ajibade, Temitayo Olabisi</creatorcontrib><creatorcontrib>Ola-Davies, Olufunke Eunice</creatorcontrib><creatorcontrib>Omobowale, Temidayo Olutayo</creatorcontrib><creatorcontrib>Ajani, Olumide Samuel</creatorcontrib><creatorcontrib>Jarikre, Theophilus Aghogho</creatorcontrib><creatorcontrib>Soetan, Kehinde Olugboyega</creatorcontrib><creatorcontrib>Saba, Adebowale Benard</creatorcontrib><creatorcontrib>Adedapo, Adeolu Alex</creatorcontrib><creatorcontrib>Obemisola Aro, Abimbola</creatorcontrib><creatorcontrib>Olugbenga Oyeyemi, Matthew</creatorcontrib><creatorcontrib>Obukowho Emikpe, Benjamin</creatorcontrib><creatorcontrib>Nkadimeng, Sanah Malomile</creatorcontrib><creatorcontrib>Joy McGaw, Lyndy</creatorcontrib><creatorcontrib>Kayoka-Kabongo, Prudence Ngalula</creatorcontrib><creatorcontrib>Audu Yakubu, Momoh</creatorcontrib><creatorcontrib>Oguntibeju, Oluwafemi Omoniyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oyagbemi, Ademola Adetokunbo</au><au>Hassan, Fasilat Oluwakemi</au><au>Ajibade, Temitayo Olabisi</au><au>Ola-Davies, Olufunke Eunice</au><au>Omobowale, Temidayo Olutayo</au><au>Ajani, Olumide Samuel</au><au>Jarikre, Theophilus Aghogho</au><au>Soetan, Kehinde Olugboyega</au><au>Saba, Adebowale Benard</au><au>Adedapo, Adeolu Alex</au><au>Obemisola Aro, Abimbola</au><au>Olugbenga Oyeyemi, Matthew</au><au>Obukowho Emikpe, Benjamin</au><au>Nkadimeng, Sanah Malomile</au><au>Joy McGaw, Lyndy</au><au>Kayoka-Kabongo, Prudence Ngalula</au><au>Audu Yakubu, Momoh</au><au>Oguntibeju, Oluwafemi Omoniyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2022-11</date><risdate>2022</risdate><volume>35</volume><issue>6</issue><spage>1581</spage><epage>1694</epage><pages>1581-1694</pages><issn>1011-601X</issn><abstract>Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>36789818</pmid><doi>10.36721/PJPS.2022.35.6.REG.1581-1594.1</doi><tpages>114</tpages></addata></record> |
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| subjects | Animals Antihypertensive Agents - pharmacology Antioxidants - pharmacology Asteraceae Blood Pressure Care and treatment Chemical properties Development and progression Health aspects Hypertension Hypertension - drug therapy Hypertension - metabolism Male Materia medica, Vegetable Medicinal plants NG-Nitroarginine Methyl Ester Nitric Oxide - metabolism Oxidative Stress Physiological aspects Plant extracts Plant Extracts - pharmacology Rats Rats, Wistar Sodium |
| title | Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action |
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