Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis
Current literature regarding the association of vitamin D insufficiency and food allergy is contradicting. The purpose of our study was to investigate this association. This is a systematic review and meta-analysis according to the PRISMA statement. PubMeD and Scopus databases were systematically se...
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| Veröffentlicht in: | European journal of pediatrics 2023-04, Vol.182 (4), p.1533-1554 |
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| container_title | European journal of pediatrics |
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| creator | Psaroulaki, Evdokia Katsaras, Georgios N. Samartzi, Petrina Chatziravdeli, Vasiliki Psaroulaki, Danai Oikonomou, Evangelos Tsitsani, Pelagia |
| description | Current literature regarding the association of vitamin D insufficiency and food allergy is contradicting. The purpose of our study was to investigate this association. This is a systematic review and meta-analysis according to the PRISMA statement. PubMeD and Scopus databases were systematically searched for case–control studies investigating the association between pediatric food allergy and vitamin D insufficiency. Our search yielded 806 studies. Ten final studies were considered eligible for qualitative and quantitative analysis. Children with vitamin D insufficiency were found to have 68% more probability to present a food allergy episode (adjusted pooled OR: 1.68, 95% CI [1.25–2.27],
p
-value: 0.001). In their second year of life they were 4 times more likely to present a food allergy episode (adjusted pooled OR: 4.06, 95% CI [1.93–8.56],
p
-value: |
| doi_str_mv | 10.1007/s00431-023-04843-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2777009302</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811064329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ee4e6af35fcb925290001a83846d52bbb7a3a99d7659a4929be567e97576b5533</originalsourceid><addsrcrecordid>eNp9kc1O3TAQha0KVOC2L9AFssSmmxT_xHHcHbq0FAmJDV1bjjMBQxJTTwLK2-PbSwtiwcqW55zPo3MI-cLZN86YPkbGSskLJmTByrqUhfhA9nkpRcGZrnZe3ffIAeItyybD649kT1babCz75O4EMfrgphBHGjvaxdhS1_eQrhcaRupvQt8mGOljmG7oQ5jckF9P8wjnrgs-wOiX79RRXHCCIXM8TfAQ4JG6saUDTK5wo-sXDPiJ7HauR_j8fK7I758_rta_iovLs_P1yUXhpVZTAVBC5TqpOt8YoYTJe3NXy7qsWiWaptFOOmNaXSnjSiNMA6rSYLTSVaOUlCvydcu9T_HPDDjZIaCHvncjxBmt0FozZmQObkWO3khv45zyvllVc86qnKDJKrFV-RQRE3T2PoXBpcVyZjdV2G0VNhPt3yrsBn34jJ6bAdr_ln_ZZ4HcCjCPxmtIL3-_g30CnxKTww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2811064329</pqid></control><display><type>article</type><title>Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Psaroulaki, Evdokia ; Katsaras, Georgios N. ; Samartzi, Petrina ; Chatziravdeli, Vasiliki ; Psaroulaki, Danai ; Oikonomou, Evangelos ; Tsitsani, Pelagia</creator><creatorcontrib>Psaroulaki, Evdokia ; Katsaras, Georgios N. ; Samartzi, Petrina ; Chatziravdeli, Vasiliki ; Psaroulaki, Danai ; Oikonomou, Evangelos ; Tsitsani, Pelagia</creatorcontrib><description>Current literature regarding the association of vitamin D insufficiency and food allergy is contradicting. The purpose of our study was to investigate this association. This is a systematic review and meta-analysis according to the PRISMA statement. PubMeD and Scopus databases were systematically searched for case–control studies investigating the association between pediatric food allergy and vitamin D insufficiency. Our search yielded 806 studies. Ten final studies were considered eligible for qualitative and quantitative analysis. Children with vitamin D insufficiency were found to have 68% more probability to present a food allergy episode (adjusted pooled OR: 1.68, 95% CI [1.25–2.27],
p
-value: 0.001). In their second year of life they were 4 times more likely to present a food allergy episode (adjusted pooled OR: 4.06, 95% CI [1.93–8.56],
p
-value: < 0.001), and 56% more probable to develop food sensitization (OR: 1.56, 95% CI [1.15–2.11],
p
-value: < 0.004). Children in Australia with vitamin D insufficiency were almost 4 times more likely to develop egg sensitization (adjusted OR: 3.79, 95% CI [1.19–12.08],
p
-value: 0.024). Children with vitamin D insufficiency were almost twice as likely to have peanut sensitization (OR: 1.96, 95% CI [1.08–3.57],
p
-value: 0.028).
Conclusion
: Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies, particularly in the second year of life. To confirm this association, multicenter longitudinal studies are required.
What is Known:
• In newborns and young children, vitamin D deficiency and insufficiency are prevalent.
• The exact role of vitamin D in atopic diseases remains controversial.
What is New:
• Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies. This association is more evident in the second year of life.</description><identifier>ISSN: 1432-1076</identifier><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-023-04843-2</identifier><identifier>PMID: 36790484</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Allergens ; Atopy ; Child ; Child, Preschool ; Children ; Food allergies ; Food Hypersensitivity - complications ; Food Hypersensitivity - epidemiology ; Humans ; Infant ; Infant, Newborn ; Infants ; Medicine ; Medicine & Public Health ; Meta-analysis ; Multicenter Studies as Topic ; Neonates ; Pediatrics ; Review ; Systematic review ; Vitamin D ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology ; Vitamin deficiency ; Vitamins ; Winter</subject><ispartof>European journal of pediatrics, 2023-04, Vol.182 (4), p.1533-1554</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ee4e6af35fcb925290001a83846d52bbb7a3a99d7659a4929be567e97576b5533</citedby><cites>FETCH-LOGICAL-c375t-ee4e6af35fcb925290001a83846d52bbb7a3a99d7659a4929be567e97576b5533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-023-04843-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-023-04843-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36790484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Psaroulaki, Evdokia</creatorcontrib><creatorcontrib>Katsaras, Georgios N.</creatorcontrib><creatorcontrib>Samartzi, Petrina</creatorcontrib><creatorcontrib>Chatziravdeli, Vasiliki</creatorcontrib><creatorcontrib>Psaroulaki, Danai</creatorcontrib><creatorcontrib>Oikonomou, Evangelos</creatorcontrib><creatorcontrib>Tsitsani, Pelagia</creatorcontrib><title>Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>Current literature regarding the association of vitamin D insufficiency and food allergy is contradicting. The purpose of our study was to investigate this association. This is a systematic review and meta-analysis according to the PRISMA statement. PubMeD and Scopus databases were systematically searched for case–control studies investigating the association between pediatric food allergy and vitamin D insufficiency. Our search yielded 806 studies. Ten final studies were considered eligible for qualitative and quantitative analysis. Children with vitamin D insufficiency were found to have 68% more probability to present a food allergy episode (adjusted pooled OR: 1.68, 95% CI [1.25–2.27],
p
-value: 0.001). In their second year of life they were 4 times more likely to present a food allergy episode (adjusted pooled OR: 4.06, 95% CI [1.93–8.56],
p
-value: < 0.001), and 56% more probable to develop food sensitization (OR: 1.56, 95% CI [1.15–2.11],
p
-value: < 0.004). Children in Australia with vitamin D insufficiency were almost 4 times more likely to develop egg sensitization (adjusted OR: 3.79, 95% CI [1.19–12.08],
p
-value: 0.024). Children with vitamin D insufficiency were almost twice as likely to have peanut sensitization (OR: 1.96, 95% CI [1.08–3.57],
p
-value: 0.028).
Conclusion
: Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies, particularly in the second year of life. To confirm this association, multicenter longitudinal studies are required.
What is Known:
• In newborns and young children, vitamin D deficiency and insufficiency are prevalent.
• The exact role of vitamin D in atopic diseases remains controversial.
What is New:
• Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies. This association is more evident in the second year of life.</description><subject>Allergens</subject><subject>Atopy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Food allergies</subject><subject>Food Hypersensitivity - complications</subject><subject>Food Hypersensitivity - epidemiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Multicenter Studies as Topic</subject><subject>Neonates</subject><subject>Pediatrics</subject><subject>Review</subject><subject>Systematic review</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin deficiency</subject><subject>Vitamins</subject><subject>Winter</subject><issn>1432-1076</issn><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1O3TAQha0KVOC2L9AFssSmmxT_xHHcHbq0FAmJDV1bjjMBQxJTTwLK2-PbSwtiwcqW55zPo3MI-cLZN86YPkbGSskLJmTByrqUhfhA9nkpRcGZrnZe3ffIAeItyybD649kT1babCz75O4EMfrgphBHGjvaxdhS1_eQrhcaRupvQt8mGOljmG7oQ5jckF9P8wjnrgs-wOiX79RRXHCCIXM8TfAQ4JG6saUDTK5wo-sXDPiJ7HauR_j8fK7I758_rta_iovLs_P1yUXhpVZTAVBC5TqpOt8YoYTJe3NXy7qsWiWaptFOOmNaXSnjSiNMA6rSYLTSVaOUlCvydcu9T_HPDDjZIaCHvncjxBmt0FozZmQObkWO3khv45zyvllVc86qnKDJKrFV-RQRE3T2PoXBpcVyZjdV2G0VNhPt3yrsBn34jJ6bAdr_ln_ZZ4HcCjCPxmtIL3-_g30CnxKTww</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Psaroulaki, Evdokia</creator><creator>Katsaras, Georgios N.</creator><creator>Samartzi, Petrina</creator><creator>Chatziravdeli, Vasiliki</creator><creator>Psaroulaki, Danai</creator><creator>Oikonomou, Evangelos</creator><creator>Tsitsani, Pelagia</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20230401</creationdate><title>Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis</title><author>Psaroulaki, Evdokia ; Katsaras, Georgios N. ; Samartzi, Petrina ; Chatziravdeli, Vasiliki ; Psaroulaki, Danai ; Oikonomou, Evangelos ; Tsitsani, Pelagia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ee4e6af35fcb925290001a83846d52bbb7a3a99d7659a4929be567e97576b5533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergens</topic><topic>Atopy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Food allergies</topic><topic>Food Hypersensitivity - complications</topic><topic>Food Hypersensitivity - epidemiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Multicenter Studies as Topic</topic><topic>Neonates</topic><topic>Pediatrics</topic><topic>Review</topic><topic>Systematic review</topic><topic>Vitamin D</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin deficiency</topic><topic>Vitamins</topic><topic>Winter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Psaroulaki, Evdokia</creatorcontrib><creatorcontrib>Katsaras, Georgios N.</creatorcontrib><creatorcontrib>Samartzi, Petrina</creatorcontrib><creatorcontrib>Chatziravdeli, Vasiliki</creatorcontrib><creatorcontrib>Psaroulaki, Danai</creatorcontrib><creatorcontrib>Oikonomou, Evangelos</creatorcontrib><creatorcontrib>Tsitsani, Pelagia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Psaroulaki, Evdokia</au><au>Katsaras, Georgios N.</au><au>Samartzi, Petrina</au><au>Chatziravdeli, Vasiliki</au><au>Psaroulaki, Danai</au><au>Oikonomou, Evangelos</au><au>Tsitsani, Pelagia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>182</volume><issue>4</issue><spage>1533</spage><epage>1554</epage><pages>1533-1554</pages><issn>1432-1076</issn><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>Current literature regarding the association of vitamin D insufficiency and food allergy is contradicting. The purpose of our study was to investigate this association. This is a systematic review and meta-analysis according to the PRISMA statement. PubMeD and Scopus databases were systematically searched for case–control studies investigating the association between pediatric food allergy and vitamin D insufficiency. Our search yielded 806 studies. Ten final studies were considered eligible for qualitative and quantitative analysis. Children with vitamin D insufficiency were found to have 68% more probability to present a food allergy episode (adjusted pooled OR: 1.68, 95% CI [1.25–2.27],
p
-value: 0.001). In their second year of life they were 4 times more likely to present a food allergy episode (adjusted pooled OR: 4.06, 95% CI [1.93–8.56],
p
-value: < 0.001), and 56% more probable to develop food sensitization (OR: 1.56, 95% CI [1.15–2.11],
p
-value: < 0.004). Children in Australia with vitamin D insufficiency were almost 4 times more likely to develop egg sensitization (adjusted OR: 3.79, 95% CI [1.19–12.08],
p
-value: 0.024). Children with vitamin D insufficiency were almost twice as likely to have peanut sensitization (OR: 1.96, 95% CI [1.08–3.57],
p
-value: 0.028).
Conclusion
: Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies, particularly in the second year of life. To confirm this association, multicenter longitudinal studies are required.
What is Known:
• In newborns and young children, vitamin D deficiency and insufficiency are prevalent.
• The exact role of vitamin D in atopic diseases remains controversial.
What is New:
• Decreased maternal vitamin D levels and infant vitamin D insufficiency appear to increase the incidence of food allergies. This association is more evident in the second year of life.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36790484</pmid><doi>10.1007/s00431-023-04843-2</doi><tpages>22</tpages></addata></record> |
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| ispartof | European journal of pediatrics, 2023-04, Vol.182 (4), p.1533-1554 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Allergens Atopy Child Child, Preschool Children Food allergies Food Hypersensitivity - complications Food Hypersensitivity - epidemiology Humans Infant Infant, Newborn Infants Medicine Medicine & Public Health Meta-analysis Multicenter Studies as Topic Neonates Pediatrics Review Systematic review Vitamin D Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency Vitamins Winter |
| title | Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis |
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