γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors

Research shows that Vδ1 and Vδ3 γδ T cells that express PD-1 and display potent cytotoxic functions are key immune responders in HLA-class-I-negative colon cancers subjected to immune checkpoint blockade therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2023-03, Vol.24 (3), p.387-388
Hauptverfasser:	Silva-Santos, Bruno, Mensurado, Sofia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 692/699/67/580 Antigens Biomedical and Life Sciences Biomedicine Colorectal cancer Cytotoxicity Humans Immune checkpoint inhibitors Immunology Immunotherapy Immunotherapy, Adoptive Infectious Diseases Lymphocytes Lymphocytes T Major histocompatibility complex Neoplasms News & Views news-and-views PD-1 protein Receptors, Antigen, T-Cell, gamma-delta T cell receptors T-Lymphocytes Tumors
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Beschreibung
Zusammenfassung:	Research shows that Vδ1 and Vδ3 γδ T cells that express PD-1 and display potent cytotoxic functions are key immune responders in HLA-class-I-negative colon cancers subjected to immune checkpoint blockade therapy.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-023-01429-w