Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls
Objective To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD). Method We examined the association between serum levels of zonulin and occluding, and behavioral/emotional pr...
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| Veröffentlicht in: | Indian pediatrics 2023-02, Vol.60 (2), p.137-141 |
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| creator | Çakir, Ali Dogru, Hicran Laloglu, Esra |
| description | Objective
To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD).
Method
We examined the association between serum levels of zonulin and occluding, and behavioral/emotional problems in children with ADHD. 40 medication-naïve children meeting Diagnostic and statistical (DSM-5) criteria for ADHD (11 females; mean (SD) age 9.4 (1.6) years) and 39 healthy comparisons (12 females; mean (SD) age 9.3 (1.9) years) were studied. Serum zonulin and occludin levels were measured by (ELISA).
Result
We found higher mean (SD) serum zonulin levels [37.1 (28.2) vs 8.1 (4.5) ng/mL;
P |
| doi_str_mv | 10.1007/s13312-023-2812-1 |
| format | Article |
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To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD).
Method
We examined the association between serum levels of zonulin and occluding, and behavioral/emotional problems in children with ADHD. 40 medication-naïve children meeting Diagnostic and statistical (DSM-5) criteria for ADHD (11 females; mean (SD) age 9.4 (1.6) years) and 39 healthy comparisons (12 females; mean (SD) age 9.3 (1.9) years) were studied. Serum zonulin and occludin levels were measured by (ELISA).
Result
We found higher mean (SD) serum zonulin levels [37.1 (28.2) vs 8.1 (4.5) ng/mL;
P
<0.001) and occludin levels [2.4 (1.6) vs 0.6 (0.4) ng/mL;
P
<0.001] in the ADHD group compared to control group. Serum zonulin levels had a positive correlation with weight (r=0.452;
P
=0.003) and BMI (r=0.401;
P
=0.01) among children with ADHD. Serum zonulin and occludin levels also had a positive correlation with Conners parent rating scale scores (r=0.58; P<0.001), and Strengths and difficulties questionnaire scores (r=0.49;
P
<0.001). Multiple linear regression analysis revealed that age, sex, weight, conduct problems and oppositional sub-scores were significant predictors of increased serum zonulin levels.
Conclusion
These data confirm an association between ADHD, and serum zonulin and occludin levels. Pathophysiological and clinical significance of these findings needs to be elucidated.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-023-2812-1</identifier><identifier>PMID: 36786182</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Attention Deficit Disorder with Hyperactivity - diagnosis ; Child ; Female ; Haptoglobins ; Humans ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Occludin ; Pediatric Surgery ; Pediatrics ; Protein Precursors ; Research Paper</subject><ispartof>Indian pediatrics, 2023-02, Vol.60 (2), p.137-141</ispartof><rights>Indian Academy of Pediatrics 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-eef99ec2689ff5a974af15bf0c85082d3cae9ad8d92f426d107fc507e2741a573</citedby><cites>FETCH-LOGICAL-c344t-eef99ec2689ff5a974af15bf0c85082d3cae9ad8d92f426d107fc507e2741a573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13312-023-2812-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13312-023-2812-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36786182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çakir, Ali</creatorcontrib><creatorcontrib>Dogru, Hicran</creatorcontrib><creatorcontrib>Laloglu, Esra</creatorcontrib><title>Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objective
To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD).
Method
We examined the association between serum levels of zonulin and occluding, and behavioral/emotional problems in children with ADHD. 40 medication-naïve children meeting Diagnostic and statistical (DSM-5) criteria for ADHD (11 females; mean (SD) age 9.4 (1.6) years) and 39 healthy comparisons (12 females; mean (SD) age 9.3 (1.9) years) were studied. Serum zonulin and occludin levels were measured by (ELISA).
Result
We found higher mean (SD) serum zonulin levels [37.1 (28.2) vs 8.1 (4.5) ng/mL;
P
<0.001) and occludin levels [2.4 (1.6) vs 0.6 (0.4) ng/mL;
P
<0.001] in the ADHD group compared to control group. Serum zonulin levels had a positive correlation with weight (r=0.452;
P
=0.003) and BMI (r=0.401;
P
=0.01) among children with ADHD. Serum zonulin and occludin levels also had a positive correlation with Conners parent rating scale scores (r=0.58; P<0.001), and Strengths and difficulties questionnaire scores (r=0.49;
P
<0.001). Multiple linear regression analysis revealed that age, sex, weight, conduct problems and oppositional sub-scores were significant predictors of increased serum zonulin levels.
Conclusion
These data confirm an association between ADHD, and serum zonulin and occludin levels. Pathophysiological and clinical significance of these findings needs to be elucidated.</description><subject>Attention Deficit Disorder with Hyperactivity - diagnosis</subject><subject>Child</subject><subject>Female</subject><subject>Haptoglobins</subject><subject>Humans</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Occludin</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Protein Precursors</subject><subject>Research Paper</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFOJCEQhonRqKs-wF5MH730CnTTNEcz6o7JJB7UmHghCIWDYWAE2mTeXtxxPXqqP6mv_qQ-hH4T_IdgzM8z6TpCW0y7lo41kB10iAXvW86Y2K0ZE9EOeCAH6FfOr7iClJF9dNANfBzISA_R-g7StGputfaTcaFRwTRPMUy-5gW8g89NTbOl8yZBaB5dWTYXpUAoLob2EqzTrpzPN2tIShf37sqmuXQ5JgPpX9kclC_LTTOLoaTo8zHas8pnOPmaR-jh-up-Nm8Xt39vZheLVnd9X1oAKwRoOozCWqbqU8oS9myxHhkeqem0AqHMaAS1PR0MwdxqhjlQ3hPFeHeEzra96xTfJshFrlzW4L0KEKcsKecDI6LvxoqSLapTzDmBlevkViptJMHyU7TcipbVn_wULUm9Of2qn55XYL4v_putAN0Cua7CCyT5GqcU6ss_tH4AhuaKJA</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Çakir, Ali</creator><creator>Dogru, Hicran</creator><creator>Laloglu, Esra</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls</title><author>Çakir, Ali ; Dogru, Hicran ; Laloglu, Esra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-eef99ec2689ff5a974af15bf0c85082d3cae9ad8d92f426d107fc507e2741a573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Attention Deficit Disorder with Hyperactivity - diagnosis</topic><topic>Child</topic><topic>Female</topic><topic>Haptoglobins</topic><topic>Humans</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Occludin</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Protein Precursors</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çakir, Ali</creatorcontrib><creatorcontrib>Dogru, Hicran</creatorcontrib><creatorcontrib>Laloglu, Esra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çakir, Ali</au><au>Dogru, Hicran</au><au>Laloglu, Esra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><addtitle>Indian Pediatr</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>60</volume><issue>2</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objective
To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD).
Method
We examined the association between serum levels of zonulin and occluding, and behavioral/emotional problems in children with ADHD. 40 medication-naïve children meeting Diagnostic and statistical (DSM-5) criteria for ADHD (11 females; mean (SD) age 9.4 (1.6) years) and 39 healthy comparisons (12 females; mean (SD) age 9.3 (1.9) years) were studied. Serum zonulin and occludin levels were measured by (ELISA).
Result
We found higher mean (SD) serum zonulin levels [37.1 (28.2) vs 8.1 (4.5) ng/mL;
P
<0.001) and occludin levels [2.4 (1.6) vs 0.6 (0.4) ng/mL;
P
<0.001] in the ADHD group compared to control group. Serum zonulin levels had a positive correlation with weight (r=0.452;
P
=0.003) and BMI (r=0.401;
P
=0.01) among children with ADHD. Serum zonulin and occludin levels also had a positive correlation with Conners parent rating scale scores (r=0.58; P<0.001), and Strengths and difficulties questionnaire scores (r=0.49;
P
<0.001). Multiple linear regression analysis revealed that age, sex, weight, conduct problems and oppositional sub-scores were significant predictors of increased serum zonulin levels.
Conclusion
These data confirm an association between ADHD, and serum zonulin and occludin levels. Pathophysiological and clinical significance of these findings needs to be elucidated.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>36786182</pmid><doi>10.1007/s13312-023-2812-1</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Attention Deficit Disorder with Hyperactivity - diagnosis Child Female Haptoglobins Humans Maternal and Child Health Medicine Medicine & Public Health Occludin Pediatric Surgery Pediatrics Protein Precursors Research Paper |
| title | Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls |
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