Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis
Background Inflammation plays an important role in tumor growth. Novel serum blood biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been proposed as useful prognostic indexes in cancer patients. However, thei...
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| Veröffentlicht in: | Langenbeck's archives of surgery 2023-02, Vol.408 (1), p.85-85, Article 85 |
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| creator | Portale, Giuseppe Bartolotta, Patrizia Azzolina, Danila Gregori, Dario Fiscon, Valentino |
| description | Background
Inflammation plays an important role in tumor growth. Novel serum blood biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been proposed as useful prognostic indexes in cancer patients. However, their role in rectal cancer is controversial.
Methods
A comprehensive literature review was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, and the Cochrane Database of Systematic Reviews through May 2022. The systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Quality was appraised with the Methodological Index for Non-Randomized Studies (MINORS) tool. Aim of the study was to summarize available literature on PLR, NLR, and LMR in patients with rectal cancer undergoing resection.
Results
Forty-seven observational studies (14,205 patients) were included; there were 42 retrospective and 5 prospective cohort studies with an average MINORS score of 14.6 (range: 12–18). Worse overall survival was associated with high NLR (HR 1.81; 95%CI 1.52–2.15;
p
|
| doi_str_mv | 10.1007/s00423-023-02786-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2776517420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2776517420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-7397bc1a89fb55932861cf86ba12bf5e033a0a0a51bf4db11141b5e1f65f53e63</originalsourceid><addsrcrecordid>eNp9Uctu1TAQtRAVfcAPsEBesqjBE8dxLjtUQUGqRBft2nJ8x20qxw62U5Tv4gdx7y1QNmg0mrHOQyMfQl4Dfwecq_eZ87YRjO9a9R3rn5EjaIVkTSvh-ZP9kBznfMc579SmfUEORad6kMCPyM_LFG9CzGW0NEWPNDo6e1PQY2ElMr9O8220a0GaTBnjKQ24lBTn29H_i59SE7b07_sBnWJ4oqVjoHHGuuOWJrTFeGpNsJjoXHEMJX-gec0FJ7O7B-9H_LGznbAYZoLxax7zS3LgjM_46nGekOvPn67OvrCLb-dfzz5eMNuCKEyJjRosmH7jBik3ouk7sK7vBgPN4CRyIQyvJWFw7XYAgBYGieA66aTATpyQt3vfOcXvC-aipzFb9N4EjEvWjVKdBNU2vFKbPdWmmHNCp-c0TiatGrh-CEvvw9J81zUs3VfRm0f_ZZhw-0fyO51KEHtCrlC4waTv4pLqL-T_2f4CMJWk_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2776517420</pqid></control><display><type>article</type><title>Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Portale, Giuseppe ; Bartolotta, Patrizia ; Azzolina, Danila ; Gregori, Dario ; Fiscon, Valentino</creator><creatorcontrib>Portale, Giuseppe ; Bartolotta, Patrizia ; Azzolina, Danila ; Gregori, Dario ; Fiscon, Valentino</creatorcontrib><description>Background
Inflammation plays an important role in tumor growth. Novel serum blood biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been proposed as useful prognostic indexes in cancer patients. However, their role in rectal cancer is controversial.
Methods
A comprehensive literature review was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, and the Cochrane Database of Systematic Reviews through May 2022. The systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Quality was appraised with the Methodological Index for Non-Randomized Studies (MINORS) tool. Aim of the study was to summarize available literature on PLR, NLR, and LMR in patients with rectal cancer undergoing resection.
Results
Forty-seven observational studies (14,205 patients) were included; there were 42 retrospective and 5 prospective cohort studies with an average MINORS score of 14.6 (range: 12–18). Worse overall survival was associated with high NLR (HR 1.81; 95%CI 1.52–2.15;
p
< 0.001), high PLR (HR 1.24; 95%CI 1.06–1.46;
p
= 0.009), and low LMR (HR 0.67; 95%CI 0.49–0.91;
p
= 0.01). High NLR and low LMR were also associated with disease-free-survival (HR 1.68; 95%CI 1.35–2.08;
p
< 0.001 and HR 0.71; 95%CI 0.58–0.87;
p
< 0.001, respectively).
Conclusions
NLR, PLR, and LMR are independent clinical predictors for overall survival in patients with rectal cancer treated with curative surgery. NLR and LMR are also good predictors for disease free survival. These biomarkers, which are readily available, appear optimal prognostic indexes and may help clinicians predict the prognosis of rectal cancer and develop individualized treatment strategies.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-023-02786-8</identifier><identifier>PMID: 36781510</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Biomarkers ; Cardiac Surgery ; General Surgery ; Humans ; Lymphocytes ; Medicine ; Medicine & Public Health ; Monocytes ; Neutrophils ; Prognosis ; Prospective Studies ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Retrospective Studies ; Review ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2023-02, Vol.408 (1), p.85-85, Article 85</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-7397bc1a89fb55932861cf86ba12bf5e033a0a0a51bf4db11141b5e1f65f53e63</citedby><cites>FETCH-LOGICAL-c413t-7397bc1a89fb55932861cf86ba12bf5e033a0a0a51bf4db11141b5e1f65f53e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-023-02786-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-023-02786-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36781510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Portale, Giuseppe</creatorcontrib><creatorcontrib>Bartolotta, Patrizia</creatorcontrib><creatorcontrib>Azzolina, Danila</creatorcontrib><creatorcontrib>Gregori, Dario</creatorcontrib><creatorcontrib>Fiscon, Valentino</creatorcontrib><title>Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Background
Inflammation plays an important role in tumor growth. Novel serum blood biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been proposed as useful prognostic indexes in cancer patients. However, their role in rectal cancer is controversial.
Methods
A comprehensive literature review was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, and the Cochrane Database of Systematic Reviews through May 2022. The systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Quality was appraised with the Methodological Index for Non-Randomized Studies (MINORS) tool. Aim of the study was to summarize available literature on PLR, NLR, and LMR in patients with rectal cancer undergoing resection.
Results
Forty-seven observational studies (14,205 patients) were included; there were 42 retrospective and 5 prospective cohort studies with an average MINORS score of 14.6 (range: 12–18). Worse overall survival was associated with high NLR (HR 1.81; 95%CI 1.52–2.15;
p
< 0.001), high PLR (HR 1.24; 95%CI 1.06–1.46;
p
= 0.009), and low LMR (HR 0.67; 95%CI 0.49–0.91;
p
= 0.01). High NLR and low LMR were also associated with disease-free-survival (HR 1.68; 95%CI 1.35–2.08;
p
< 0.001 and HR 0.71; 95%CI 0.58–0.87;
p
< 0.001, respectively).
Conclusions
NLR, PLR, and LMR are independent clinical predictors for overall survival in patients with rectal cancer treated with curative surgery. NLR and LMR are also good predictors for disease free survival. These biomarkers, which are readily available, appear optimal prognostic indexes and may help clinicians predict the prognosis of rectal cancer and develop individualized treatment strategies.</description><subject>Abdominal Surgery</subject><subject>Biomarkers</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monocytes</subject><subject>Neutrophils</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Review</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAQtRAVfcAPsEBesqjBE8dxLjtUQUGqRBft2nJ8x20qxw62U5Tv4gdx7y1QNmg0mrHOQyMfQl4Dfwecq_eZ87YRjO9a9R3rn5EjaIVkTSvh-ZP9kBznfMc579SmfUEORad6kMCPyM_LFG9CzGW0NEWPNDo6e1PQY2ElMr9O8220a0GaTBnjKQ24lBTn29H_i59SE7b07_sBnWJ4oqVjoHHGuuOWJrTFeGpNsJjoXHEMJX-gec0FJ7O7B-9H_LGznbAYZoLxax7zS3LgjM_46nGekOvPn67OvrCLb-dfzz5eMNuCKEyJjRosmH7jBik3ouk7sK7vBgPN4CRyIQyvJWFw7XYAgBYGieA66aTATpyQt3vfOcXvC-aipzFb9N4EjEvWjVKdBNU2vFKbPdWmmHNCp-c0TiatGrh-CEvvw9J81zUs3VfRm0f_ZZhw-0fyO51KEHtCrlC4waTv4pLqL-T_2f4CMJWk_g</recordid><startdate>20230213</startdate><enddate>20230213</enddate><creator>Portale, Giuseppe</creator><creator>Bartolotta, Patrizia</creator><creator>Azzolina, Danila</creator><creator>Gregori, Dario</creator><creator>Fiscon, Valentino</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230213</creationdate><title>Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis</title><author>Portale, Giuseppe ; Bartolotta, Patrizia ; Azzolina, Danila ; Gregori, Dario ; Fiscon, Valentino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-7397bc1a89fb55932861cf86ba12bf5e033a0a0a51bf4db11141b5e1f65f53e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdominal Surgery</topic><topic>Biomarkers</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monocytes</topic><topic>Neutrophils</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Review</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Portale, Giuseppe</creatorcontrib><creatorcontrib>Bartolotta, Patrizia</creatorcontrib><creatorcontrib>Azzolina, Danila</creatorcontrib><creatorcontrib>Gregori, Dario</creatorcontrib><creatorcontrib>Fiscon, Valentino</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Portale, Giuseppe</au><au>Bartolotta, Patrizia</au><au>Azzolina, Danila</au><au>Gregori, Dario</au><au>Fiscon, Valentino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2023-02-13</date><risdate>2023</risdate><volume>408</volume><issue>1</issue><spage>85</spage><epage>85</epage><pages>85-85</pages><artnum>85</artnum><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Background
Inflammation plays an important role in tumor growth. Novel serum blood biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been proposed as useful prognostic indexes in cancer patients. However, their role in rectal cancer is controversial.
Methods
A comprehensive literature review was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, and the Cochrane Database of Systematic Reviews through May 2022. The systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Quality was appraised with the Methodological Index for Non-Randomized Studies (MINORS) tool. Aim of the study was to summarize available literature on PLR, NLR, and LMR in patients with rectal cancer undergoing resection.
Results
Forty-seven observational studies (14,205 patients) were included; there were 42 retrospective and 5 prospective cohort studies with an average MINORS score of 14.6 (range: 12–18). Worse overall survival was associated with high NLR (HR 1.81; 95%CI 1.52–2.15;
p
< 0.001), high PLR (HR 1.24; 95%CI 1.06–1.46;
p
= 0.009), and low LMR (HR 0.67; 95%CI 0.49–0.91;
p
= 0.01). High NLR and low LMR were also associated with disease-free-survival (HR 1.68; 95%CI 1.35–2.08;
p
< 0.001 and HR 0.71; 95%CI 0.58–0.87;
p
< 0.001, respectively).
Conclusions
NLR, PLR, and LMR are independent clinical predictors for overall survival in patients with rectal cancer treated with curative surgery. NLR and LMR are also good predictors for disease free survival. These biomarkers, which are readily available, appear optimal prognostic indexes and may help clinicians predict the prognosis of rectal cancer and develop individualized treatment strategies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36781510</pmid><doi>10.1007/s00423-023-02786-8</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Biomarkers Cardiac Surgery General Surgery Humans Lymphocytes Medicine Medicine & Public Health Monocytes Neutrophils Prognosis Prospective Studies Rectal Neoplasms - pathology Rectal Neoplasms - surgery Retrospective Studies Review Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis |
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