Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure
Aim To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF). Methods and results A total of 141 male patients with HF underwent dual energy X‐ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower ver...
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| Veröffentlicht in: | European journal of heart failure 2023-05, Vol.25 (5), p.714-723 |
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| container_title | European journal of heart failure |
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| creator | Loncar, Goran Garfias‐Veitl, Tania Valentova, Miroslava Vatic, Mirela Lainscak, Mitja Obradović, Danilo Dschietzig, Thomas Bernd Doehner, Wolfram Jankowska, Ewa A. Anker, Stefan D. Haehling, Stephan |
| description | Aim
To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF).
Methods and results
A total of 141 male patients with HF underwent dual energy X‐ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower versus higher BMD according to the median hip BMD (median = 1.162 g/cm2). Survival was assessed over 8 years of follow‐up. Patients with lower BMD were older (71 ± 10 vs. 66 ± 9 years, p = 0.004), more likely to be sarcopenic (37% vs. 7%, p |
| doi_str_mv | 10.1002/ejhf.2794 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2776517328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2776517328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3604-aa4bb43d19fa08044da44a9c5b9a43617f915eef64e5f82902ec38e01f24ccf23</originalsourceid><addsrcrecordid>eNp1kEtOwzAQQC0E4r_gAshLWKTYjpM47ErV0qJKLIB15CTj1CgfsJ2W7jgCZ-QkJATYsZqR5ulp9BA6o2RECWFX8LxSIxbFfAcdUhHFHhGc73a7L4QXC84O0JG1z4TQqMP30YEfRoIyQg_R201TA7ZOutZiXeMKarzRboVXII3DSuqyNXCNDdi2dBYr01TYrQA_uDbXYPGiXoN1upBO1wWeNJ_vH1VjUp1r15_HRWHkejjOv5WzQXmC9pQsLZz-zGP0NJs-Tube8v52MRkvvcwPCfek5GnK_ZzGShJBOM8l5zLOgjSW3A9ppGIaAKiQQ6AEiwmDzBdAqGI8yxTzj9HF4H0xzWvbvZpU2mZQlrKGprUJi6IwoJHPRIdeDmhmGmsNqOTF6EqabUJJ0odO-tBJH7pjz3-0bVpB_kf-lu2AqwHY6BK2_5uS6d189q38AhSEisM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2776517328</pqid></control><display><type>article</type><title>Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Loncar, Goran ; Garfias‐Veitl, Tania ; Valentova, Miroslava ; Vatic, Mirela ; Lainscak, Mitja ; Obradović, Danilo ; Dschietzig, Thomas Bernd ; Doehner, Wolfram ; Jankowska, Ewa A. ; Anker, Stefan D. ; Haehling, Stephan</creator><creatorcontrib>Loncar, Goran ; Garfias‐Veitl, Tania ; Valentova, Miroslava ; Vatic, Mirela ; Lainscak, Mitja ; Obradović, Danilo ; Dschietzig, Thomas Bernd ; Doehner, Wolfram ; Jankowska, Ewa A. ; Anker, Stefan D. ; Haehling, Stephan</creatorcontrib><description>Aim
To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF).
Methods and results
A total of 141 male patients with HF underwent dual energy X‐ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower versus higher BMD according to the median hip BMD (median = 1.162 g/cm2). Survival was assessed over 8 years of follow‐up. Patients with lower BMD were older (71 ± 10 vs. 66 ± 9 years, p = 0.004), more likely to be sarcopenic (37% vs. 7%, p < 0.001) and to have lower peak oxygen consumption (absolute peak VO2 1373 ± 480 vs. 1676 ± 447 ml/min, p < 0.001), had higher osteoprotegerin and osteocalcin levels (both p < 0.05) compared to patients with higher BMD. Among 47 patients with repeated BMD assessments, a significant reduction in BMD was noted over 30 months of follow‐up. In multivariate logistic regression analysis, serum osteocalcin remained independently related with lower BMD (odds ratio [OR] 1.738, 95% confidence interval [CI] 1.136–2.660, p = 0.011). Hip BMD and serum osteoprotegerin were independent predictors of impaired survival on Cox proportional hazard analysis (hazard ratio [HR] 0.069, 95% CI 0.011–0.444, p = 0.005, and HR 0.638, 95% CI 0.472–0.864, p = 0.004, respectively).
Conclusions
Patients with HF lose BMD over time. Markers of bone turnover can help in identifying patients at risk with osteocalcin being an independent marker of lower hip BMD and osteoprotegerin an independent predictor of death. HF patients with increased osteocalcin and osteoprotegerin may benefit from BMD assessment as manifest osteoporosis seems to be too late for clinically meaningful intervention in HF.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1002/ejhf.2794</identifier><identifier>PMID: 36781201</identifier><language>eng</language><publisher>Oxford, UK: John Wiley & Sons, Ltd</publisher><subject>Absorptiometry, Photon ; Bone Density ; Bone status ; Co‐morbidities ; Heart failure ; Heart Failure - epidemiology ; Humans ; Male ; Morbidity ; Osteocalcin ; Osteoprotegerin</subject><ispartof>European journal of heart failure, 2023-05, Vol.25 (5), p.714-723</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><rights>2023 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3604-aa4bb43d19fa08044da44a9c5b9a43617f915eef64e5f82902ec38e01f24ccf23</citedby><cites>FETCH-LOGICAL-c3604-aa4bb43d19fa08044da44a9c5b9a43617f915eef64e5f82902ec38e01f24ccf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejhf.2794$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejhf.2794$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36781201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loncar, Goran</creatorcontrib><creatorcontrib>Garfias‐Veitl, Tania</creatorcontrib><creatorcontrib>Valentova, Miroslava</creatorcontrib><creatorcontrib>Vatic, Mirela</creatorcontrib><creatorcontrib>Lainscak, Mitja</creatorcontrib><creatorcontrib>Obradović, Danilo</creatorcontrib><creatorcontrib>Dschietzig, Thomas Bernd</creatorcontrib><creatorcontrib>Doehner, Wolfram</creatorcontrib><creatorcontrib>Jankowska, Ewa A.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Haehling, Stephan</creatorcontrib><title>Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure</title><title>European journal of heart failure</title><addtitle>Eur J Heart Fail</addtitle><description>Aim
To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF).
Methods and results
A total of 141 male patients with HF underwent dual energy X‐ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower versus higher BMD according to the median hip BMD (median = 1.162 g/cm2). Survival was assessed over 8 years of follow‐up. Patients with lower BMD were older (71 ± 10 vs. 66 ± 9 years, p = 0.004), more likely to be sarcopenic (37% vs. 7%, p < 0.001) and to have lower peak oxygen consumption (absolute peak VO2 1373 ± 480 vs. 1676 ± 447 ml/min, p < 0.001), had higher osteoprotegerin and osteocalcin levels (both p < 0.05) compared to patients with higher BMD. Among 47 patients with repeated BMD assessments, a significant reduction in BMD was noted over 30 months of follow‐up. In multivariate logistic regression analysis, serum osteocalcin remained independently related with lower BMD (odds ratio [OR] 1.738, 95% confidence interval [CI] 1.136–2.660, p = 0.011). Hip BMD and serum osteoprotegerin were independent predictors of impaired survival on Cox proportional hazard analysis (hazard ratio [HR] 0.069, 95% CI 0.011–0.444, p = 0.005, and HR 0.638, 95% CI 0.472–0.864, p = 0.004, respectively).
Conclusions
Patients with HF lose BMD over time. Markers of bone turnover can help in identifying patients at risk with osteocalcin being an independent marker of lower hip BMD and osteoprotegerin an independent predictor of death. HF patients with increased osteocalcin and osteoprotegerin may benefit from BMD assessment as manifest osteoporosis seems to be too late for clinically meaningful intervention in HF.</description><subject>Absorptiometry, Photon</subject><subject>Bone Density</subject><subject>Bone status</subject><subject>Co‐morbidities</subject><subject>Heart failure</subject><subject>Heart Failure - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Morbidity</subject><subject>Osteocalcin</subject><subject>Osteoprotegerin</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQQC0E4r_gAshLWKTYjpM47ErV0qJKLIB15CTj1CgfsJ2W7jgCZ-QkJATYsZqR5ulp9BA6o2RECWFX8LxSIxbFfAcdUhHFHhGc73a7L4QXC84O0JG1z4TQqMP30YEfRoIyQg_R201TA7ZOutZiXeMKarzRboVXII3DSuqyNXCNDdi2dBYr01TYrQA_uDbXYPGiXoN1upBO1wWeNJ_vH1VjUp1r15_HRWHkejjOv5WzQXmC9pQsLZz-zGP0NJs-Tube8v52MRkvvcwPCfek5GnK_ZzGShJBOM8l5zLOgjSW3A9ppGIaAKiQQ6AEiwmDzBdAqGI8yxTzj9HF4H0xzWvbvZpU2mZQlrKGprUJi6IwoJHPRIdeDmhmGmsNqOTF6EqabUJJ0odO-tBJH7pjz3-0bVpB_kf-lu2AqwHY6BK2_5uS6d189q38AhSEisM</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Loncar, Goran</creator><creator>Garfias‐Veitl, Tania</creator><creator>Valentova, Miroslava</creator><creator>Vatic, Mirela</creator><creator>Lainscak, Mitja</creator><creator>Obradović, Danilo</creator><creator>Dschietzig, Thomas Bernd</creator><creator>Doehner, Wolfram</creator><creator>Jankowska, Ewa A.</creator><creator>Anker, Stefan D.</creator><creator>Haehling, Stephan</creator><general>John Wiley & Sons, Ltd</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202305</creationdate><title>Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure</title><author>Loncar, Goran ; Garfias‐Veitl, Tania ; Valentova, Miroslava ; Vatic, Mirela ; Lainscak, Mitja ; Obradović, Danilo ; Dschietzig, Thomas Bernd ; Doehner, Wolfram ; Jankowska, Ewa A. ; Anker, Stefan D. ; Haehling, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3604-aa4bb43d19fa08044da44a9c5b9a43617f915eef64e5f82902ec38e01f24ccf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorptiometry, Photon</topic><topic>Bone Density</topic><topic>Bone status</topic><topic>Co‐morbidities</topic><topic>Heart failure</topic><topic>Heart Failure - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Morbidity</topic><topic>Osteocalcin</topic><topic>Osteoprotegerin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loncar, Goran</creatorcontrib><creatorcontrib>Garfias‐Veitl, Tania</creatorcontrib><creatorcontrib>Valentova, Miroslava</creatorcontrib><creatorcontrib>Vatic, Mirela</creatorcontrib><creatorcontrib>Lainscak, Mitja</creatorcontrib><creatorcontrib>Obradović, Danilo</creatorcontrib><creatorcontrib>Dschietzig, Thomas Bernd</creatorcontrib><creatorcontrib>Doehner, Wolfram</creatorcontrib><creatorcontrib>Jankowska, Ewa A.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Haehling, Stephan</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loncar, Goran</au><au>Garfias‐Veitl, Tania</au><au>Valentova, Miroslava</au><au>Vatic, Mirela</au><au>Lainscak, Mitja</au><au>Obradović, Danilo</au><au>Dschietzig, Thomas Bernd</au><au>Doehner, Wolfram</au><au>Jankowska, Ewa A.</au><au>Anker, Stefan D.</au><au>Haehling, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure</atitle><jtitle>European journal of heart failure</jtitle><addtitle>Eur J Heart Fail</addtitle><date>2023-05</date><risdate>2023</risdate><volume>25</volume><issue>5</issue><spage>714</spage><epage>723</epage><pages>714-723</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Aim
To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF).
Methods and results
A total of 141 male patients with HF underwent dual energy X‐ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower versus higher BMD according to the median hip BMD (median = 1.162 g/cm2). Survival was assessed over 8 years of follow‐up. Patients with lower BMD were older (71 ± 10 vs. 66 ± 9 years, p = 0.004), more likely to be sarcopenic (37% vs. 7%, p < 0.001) and to have lower peak oxygen consumption (absolute peak VO2 1373 ± 480 vs. 1676 ± 447 ml/min, p < 0.001), had higher osteoprotegerin and osteocalcin levels (both p < 0.05) compared to patients with higher BMD. Among 47 patients with repeated BMD assessments, a significant reduction in BMD was noted over 30 months of follow‐up. In multivariate logistic regression analysis, serum osteocalcin remained independently related with lower BMD (odds ratio [OR] 1.738, 95% confidence interval [CI] 1.136–2.660, p = 0.011). Hip BMD and serum osteoprotegerin were independent predictors of impaired survival on Cox proportional hazard analysis (hazard ratio [HR] 0.069, 95% CI 0.011–0.444, p = 0.005, and HR 0.638, 95% CI 0.472–0.864, p = 0.004, respectively).
Conclusions
Patients with HF lose BMD over time. Markers of bone turnover can help in identifying patients at risk with osteocalcin being an independent marker of lower hip BMD and osteoprotegerin an independent predictor of death. HF patients with increased osteocalcin and osteoprotegerin may benefit from BMD assessment as manifest osteoporosis seems to be too late for clinically meaningful intervention in HF.</abstract><cop>Oxford, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>36781201</pmid><doi>10.1002/ejhf.2794</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of heart failure, 2023-05, Vol.25 (5), p.714-723 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Absorptiometry, Photon Bone Density Bone status Co‐morbidities Heart failure Heart Failure - epidemiology Humans Male Morbidity Osteocalcin Osteoprotegerin |
| title | Bone status in men with heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure |
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