Bach2 in CD4+ T cells from SLE patients modulates B‐cell differentiation and IgG production

T and B cells participate in the development of systemic lupus erythematosus (SLE). BTB and CNC homology 2 (Bach2) is an irreplaceable regulator in the T and B lineages that helps to maintain immune homeostasis. However, the function of Bach2 in the pathogenesis of SLE has not been studied in depth....

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Veröffentlicht in:	European journal of immunology 2023-04, Vol.53 (4), p.e2250109-n/a
Hauptverfasser:	Long, Di, Yang, Bingyi, Yang, Ming, Xiong, Feng, Zhu, Xuejing, Tan, Yixin, Wu, Haijing
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies B-Lymphocytes Bach2 ⋅ B cells ⋅ helper T (Th) cell ⋅ IgG ⋅ SLE Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Bisulfite CD19 antigen CD28 antigen CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes Cell activation Cell Differentiation Cytokines DNA methylation Electroporation Flow cytometry Helper cells Homeostasis Homology Humans Immunoglobulin G Interleukin 6 Lupus Erythematosus, Systemic Lymphocytes Lymphocytes B Lymphocytes T Systemic lupus erythematosus T-Lymphocyte Subsets T-Lymphocytes, Regulatory
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